Alkyl chain modulation of asymmetric hexacyclic fused acceptor synergistically with wide bandgap third component for high efficiency ternary organic solar cells

Herein,two asymmetric hexacyclic fused small molecule acceptors(SMAs),namely BP4F-HU and BP4F-UU,were synthesized.The elongated outside chains in the BP4F-UU molecule played a crucial role in optimizing the morphology of blend film,thereby improving charge mobility and reducing energy loss within the corresponding film.Notably,the PM6:BP4F-UU device exhibited a higher open-circuit voltage(V_(oc))of 0.878 V compared to the PM6:BP4F-HU device with a V_(oc)of 0.863 V.Further,a new wide bandgap SMA named BTP-TA was designed and synthesized as the third component to the PM6:BP4F-UU host binary devices,which showed an ideal complementary absorption spectrum in PM6:BP4F-UU system.In addition,BTP-TA can achieve efficient intermolecular energy transfer to BP4F-UU by fluorescence resonance energy transfer(FRET)pathway,due to the good overlap between the photoluminescence(PL)spectrum of BTP-TA and the absorption region of BP4F-UU.Consequently,ternary devices with 15wt%BTP-TA exhibits broader photon utilization,optimal blend morphology,and reduced charge recombination compared to the corresponding binary devices.Consequently,PM6:BP4F-UU:BTP-TA ternary device achieved an optimal power conversion efficiency(PCE)of 17.83%with simultaneously increased V_(oc)of 0.905 V,short-circuit current density(J_(sc))of 26.14 mA/cm^(2),and fill factor(FF)of 75.38%.

The Expression and Clinical Significance of ABCG2, Oct4 and Nanog in Laryngeal Carcinoma

Objective: To investigate the protein expression and clinicopathological characteristics of ABCG2, Oct4, Nanog in laryngeal cancer tissues, and to seek new molecular markers for the diagnosis of laryngeal cancer. Methods: The laryngeal cancer tissues and paracancerous tissues of 87 patients with laryngeal carcinoma diagnosed in the department of otorhinolaryngology and head and neck surgery in our hospital from April 2016 to April 2018 were selected as the subjects. QRT-PCR, Real-time PcR, Western blot and immunohistochemical staining were used to detect the expression of ABCG2, Oct4 and Nanog in (Tumor Tissue) and (Adjacent Tissue) in tumor tissue and paracancerous tissue. Results: The results of RT-PCR showed that the positive rates of ABCG2, Oct4 and Nanog in laryngeal carcinoma tissues were 49.30%, 45.07% and 52.11%, respectively, while those in paracancerous tissues were 22.54%, 21.13% and 15.49%, respectively (P < 0.01). The expression of ABCG2, Oct4 and Nanog in laryngeal carcinoma was correlated with tumor differentiation, depth of invasion, age and sex (P < 0.05), but not with tumor size and TNM stage. Conclusion: The expressions of ABCG2, Oct4 and Nanog in cancer tissues are related to tumor differentiation status, and they can be used as new molecular markers for the diagnosis of laryngeal cancer.

Biological Characteristics of Morel and Analysis of Its Cultivation Adaptability in Tianjin

Biological characteristics of morel,climatic conditions and characteristics of Tianjin,and facilities of greenhouses in Tianjin were introduced firstly,and then the cultivation adaptability of morel in Tianjin was analyzed. This study aims to let farmers learn more about the rare edible fungus——morel and provide relevant theoretical basis and feasibility reference for the promotion and application of morel cultivation in Tianjin.

An Optimal Lifetime Utility Routing for 5G and Energy-Harvesting Wireless Networks

Harvesting energy from environmental sources such as solar and wind can mitigate or solve the limited-energy problem in wireless sensor networks. In this paper, we propose an energy-harvest-aware route-selection method that incorporates harvest availability properties and energy storage capacity limits into the routing decisions. The harvest-aware routing problem is formulated as a lin- ear program with a utility-based objective function that balances the two conflicting routing objectives of maximum total and maxi- mum minimum residual network energy. The simulation results show that doing so achieves a longer network lifetime, defined as the time-to-first-node-death in the network. Additionally, most existing energy-harvesting routing algorithms route each traffic flow independently from each other. The LP formulation allows for a joint optimization of multiple trafic flows. Better residual energy statistics are also achieved by such joint consideration compared to independent optimization of each commodity.

多元融合的线上线下混合教学模式构建及应用

混合式教学成为"互联网+"时代最为合适的教学模式,通过对当前混合教学模式的研究现状进行分析,充分融合深度学习、五星教学、创客式教育和翻转课堂等教学理念基础,设计构建以实体课堂为主题、以SPOC平台为主线、融合MOOC和优质网络资源的多元融合的线上线下混合教学模式,并给出混合教学模式的具体应用研究案例。

澳大利亚草菇室内栽培技术

应澳大利亚东兴公司的邀请,我们于1992年8月抵达澳大利亚维多利亚州的阿维诺(Avenel),建立了澳洲首家草菇室内周年栽培的商业化菇场,初步获得成功,产品批量投放墨尔本等市场。现将其设备系统及配套的栽培工艺简报如下:

The clinical and genetic characteristics in children with mitochondrial disease in China

Mitochondrial disease was a clinically and genetically heterogeneous group of diseases, thus the diagnosis was very difficult to clinicians. Our objective was to analyze clinical and genetic characteristics of children with mitochondrial disease in China. We tested 141 candidate patients who have been suspected of mitochondrial disorders by using targeted next-generation sequencing(NGS), and summarized the clinical and genetic data of gene confirmed cases from Neurology Department, Beijing Children's Hospital, Capital Medical University from October 2012 to January 2015. In our study, 40 cases of gene confirmed mitochondrial disease including eight kinds of mitochondrial disease, among which Leigh syndrome was identified to be the most common type, followed by mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes(MELAS). The age-of-onset varies among mitochondrial disease, but early onset was common. All of 40 cases were gene confirmed, among which 25 cases(62.5%)with mitochondrial DNA(mtDNA) mutation, and 15 cases(37.5%) with nuclear DNA(nDNA) mutation. M.3243A>G(n=7)accounts for a large proportion of mtDNA mutation. The nDNA mutations include SURF1(n=7),PDHA1(n=2),and NDUFV1,NDUFAF6, SUCLA2, SUCLG1, RRM2 B, and C12orf65, respectively.

Erratum to:The clinical and genetic characteristics in children with mitochondrial disease in China

1.The post code for the fourth address in the affiliation should be 050031.2.Three items are missing in the first row of Table 1.The correct form of the first row is as follows:3.The second "55%"in the fourth paragraph of DISCUSSION should be 50% 4."MLEAS"in the sixth paragraph of DISCUSSION should be MELAS.

Optimal Controller Design for Non-Affine Nonlinear Power Systems with Static Var Compensators for Hybrid UAVs

A generalized non-affine nonlinear power system model is presented for a single machine bus power system with a Static Var Compensator(SVC)or State Var System(SVS)for hybrid Unmanned Aerial Vehicles(UAVs).The model is constructed by differential algebraic equations on the MATLAB-Simulink platform with the programming technique of its S-Function.Combining the inverse system method and the Linear Quadratic Regulation(LQR),an optimized SVC controller is designed.The simulations under three fault conditions show that the proposed controller can effectively improve the power system transient performance.

Interobserver Agreement and Reliability of Intrapartum Nonreassuring Cardiotocography and Prediction of Neonatal Acidemia

Objective:To evaluate the agreement and reliability of intrapartum nonreasurring cardiotocography(CTG)interpretation and prediction of neonatal acidemia by obstetricians working in different centers.Methods:A retrospective cohort study involving two tertiary hospitals(The First Affiliated Hospital of Sun Yat-sen University and Perking University Third Hospital)was conducted between 30th September 2018 and 1st April 2019.Six obstetricians from two hospitals with three levels of experience(junior,medium,and senior)reviewed 100 nonreassuring fetal heart rate(FHR)tracings from 1 hour before the onset of abnormalities until delivery.Each reviewer determined the FHR pattern,the baseline,variability,and presence of acceleration,deceleration,sinusoidal pattern,and predicted whether neonatal acidemia and abnormal umbilical arterial pH<7.1 would occur.Inter-observer agreement was assessed using the proportions of agreement(Pa)and the proportion of specific agreement(Pa for each category).Reliability was evaluated with the kappa statistic(k-Light’s kappa for n raters)and Gwet’s AC1 statistic.Results:Good inter-observer agreement was found in evaluation of most variables(Pa>0.5),with the exception of early deceleration(Pa=0.39,95%confidence interval(CI):0.36,0.43).Reliability was also good among most variables(AC1>0.40),except for acceleration,early deceleration,and prediction of neonatal acidemia(AC1=0.17,0.10,and 0.25,respectively).There were no statistically significant differences among the three groups,except in the identification of accelerations(Pa=0.89,95%CI:0.83,0.95;Pa=0.50,95%CI:0.41,0.60,and Pa=0.35,95%CI:0.25,0.43 in junior,medium and senior groups,respectively)and the prediction of neonatal acidemia(Pa=0.52,0.52,and 0.62 in junior,medium and senior groups,respectively),where agreement was highest and lowest in the junior-level group,respectively.The accuracy and sensitivity of the prediction for umbilical artery pH<7.1 were similar among the three groups,but the specificity was higher in the senior groups(93.68%vs.92.53%vs.98.85%in junior,medium and senior groups,P=0.015).Conclusion:Although we found a good inter-observer agreement in the evaluation of the most basic CTG features and FHR category statistically,it was insufficient to meet the clinical requirements for"no objection"interpretation for FHR tracings.Further specialized training is needed for standardized interpretation of intrapartum FHR tracings.

经辅助生殖技术妊娠患者早产的影响因素分析

目的探讨经辅助生殖技术(assisted reproductive technology,ART)妊娠患者发生早产的影响因素。方法选取2022年1月至2023年12月期间在华中科技大学同济医学院附属同济医院产科分娩的ART患者369例,其中早产者189例(早产组),足月分娩者180例(足月分娩组)。分析两组患者的一般资料、ART相关资料、妊娠期并发症、合并症以及新生儿情况,通过t检验和卡方检验分析两组间差异,通过Logistic回归分析影响早产的独立危险因素。结果早产组与足月分娩组比较,双胎妊娠率(40.7%vs 3.9%,χ^(2)=71.212)、孕前体质指数[(22.78±3.71)kg/m^(2) vs(21.62±3.12)kg/m^(2),t=-2.952]、原发不孕(63.8%vs 35.9%,χ^(2)=21.069)、体外受精(62.1%vs 42.2%,χ^(2)=10.491)、获卵数[(13.94±8.72)个vs(13.54±7.28)个,t=-0.402]、人绒毛膜促性腺激素注射日雌二醇水平[(2906.5±1892.0)pg/ml vs(2598.18±1456.5)pg/ml,t=-1.493]、胎膜早破(9.5%vs 0,χ^(2)=18.022)、妊娠期高血压疾病(16.9%vs 6.1%,χ^(2)=10.484)、宫颈机能不全(6.3%vs 0.6%,χ^(2)=9.105)以及卵巢相关疾病(6.3%vs 1.7%,χ^(2)=5.184)方面的差异均有统计学意义(P<0.05)。多因素Logistic回归分析提示双胎妊娠(OR=25.637,95%CI:8.782~74.844,P<0.001)、妊娠期高血压疾病(OR=2.809,95%CI:1.149~6.865,P<0.05)孕妇发生早产的风险显著增加。结论双胎妊娠、孕前超重和肥胖、原发不孕史、应用体外受精技术、获卵数多、人绒毛膜促性腺激素注射日雌二醇高水平、妊娠期高血压疾病、胎膜早破、宫颈机能不全、卵巢相关疾病均为ART妊娠患者早产的影响因素,其中妊娠期高血压疾病、双胎妊娠为ART患者早产的独立影响因素。