A novel and green route have been developed for the electrochemical synthesis of 3-halogenated spiro[4.5]trienones based on dearomative spirocyclization of alkynes with NaX(Br,I)as the halogen source.This transformati...A novel and green route have been developed for the electrochemical synthesis of 3-halogenated spiro[4.5]trienones based on dearomative spirocyclization of alkynes with NaX(Br,I)as the halogen source.This transformation was performed in an undivided cell under mild conditions.A wide range of substituted 3-halogenated spiro[4.5]trienones products was prepared in moderate-to-good yields,showing a broad scope and functional group tolerance.In addition,this approach was further extended to access fused tricyclic 6,7-dihydro-3H-pyrrolo[2,1-j]quinoline-3,9(5H)-diones.展开更多
基金We gratefully acknowledge the Provincial Planning Project of the Zhejiang Provincial Science and Technology Department(No.LGF19B060005)for financial support.
文摘A novel and green route have been developed for the electrochemical synthesis of 3-halogenated spiro[4.5]trienones based on dearomative spirocyclization of alkynes with NaX(Br,I)as the halogen source.This transformation was performed in an undivided cell under mild conditions.A wide range of substituted 3-halogenated spiro[4.5]trienones products was prepared in moderate-to-good yields,showing a broad scope and functional group tolerance.In addition,this approach was further extended to access fused tricyclic 6,7-dihydro-3H-pyrrolo[2,1-j]quinoline-3,9(5H)-diones.
