Microstructure of the Ductile Phase in Intermetallic Compound Ni_(50)Al_(20)Fe_(30)

The microstructure of the single hot extruded and annealed Ni50Al20Fe30Y0.003 intermetallic compound alloys has been examined by means of high resolution electron microscopy (HREM). In these extruded and annealed alloys. the ductile phase is of a mixture of the disordered fcc γ matrix and or dered γ' precipitates. This fact well interprets the reason why the degree of annealing treatment can influence the strength and ductility of these alloys. The HREM observation revealed directly that there was some strain concentration at γ'-γ interfaces, due to the presence of more iron atoms in these two phases. The fixed orientation relationship between the γ phase and γ' precipitates was identified to be {001}γ||{00 }γ' and <100 >γ|| < 100 > γ'

Research and Practice of Traffic Lights and Traffic Signs Recognition System Based on Multicore of FPGA

This thesis will present the research and practice of traffic lights and traffic signs recognition system based on multicore of FPGA. This system consists of four parts as following: the collection of dynamic images, the preprocessing of gray value, the detection of the edges and the patterning and the judgment of the pattern matching. The multiple cores system is consist of three cores. Each core parallels processes the incoming images from camera collection in terms of different colors and graphic elements. The image data read in from the camera works as the sharing data of the three cores.

Respective IL-17A production by γδ T and Th17 cells and its implication in host defense against chlamydial lung infection

The role of IL-17A is important in protection against lung infection with Chlamydiae,an obligate intracellular bacterial pathogen.In this study,we explored the producers of IL-17A in chlamydial lung infection and specifically tested the role of major IL-17A producers in protective immunity.We found thatγδT cells and Th17 cells are the major producers of IL-17A at the early and later stages of chlamydial infection,respectively.Depletion ofγδT cells in vivo at the early postinfection(p.i.)stage,when mostγδT cells produce IL-17A,failed to alter Th1 responses and bacterial clearance.In contrast,the blockade of IL-17A at the time when IL-17A was mainly produced by Th17(day 7 p.i.)markedly reduced the Th1 response and increased chlamydial growth.The data suggest that theγδT cell is the highest producer of IL-17A in the very early stages of infection,but the protection conferred by IL-17A is mainly mediated by Th17 cells.In addition,we found that depletion ofγδT cells reduced IL-1αproduction by dendritic cells,which was associated with a reduced Th17 response.This finding is helpful to understand the variable role of IL-17A in different infections and to develop preventive and therapeutic approaches against infectious diseases by targeting IL-17A.

CD103+ lung dendritic cells(LDCs)induce stronger Th1/Th17 immunity to a bacterial lung infection than CD11b^(hi) LDCs

Recent studies suggest differential roles for CD103+and CD11bhi lung dendritic cells(LDCs)in host defense against viral and bacterial infections.In this study,we examined the contribution of these LDC subsets in protective immunity to chlamydial lung infection using a Chlamydia muridarum mouse infection model.We found that CD103+LDCs showed higher expression of costimulatory molecules(CD40,CD80 and CD86)and increased production of cytokines(IL-12p70,IL-10,IL-23 and IL-6)compared with CD11bhi LDCs,but the expression of programmed death-ligand 1(PD-L1)was similar between the two subsets.More importantly,we found,in adoptive transfer experiments,that the mice receiving CD103+LDCs from Chlamydia-infected mice exhibited better protection than the recipients of CD11bhi LDCs,which was associated with more robust Th1/Th17 cytokine responses.In addition,in vitro experiments showed that CD103+LDCs induced stronger IFN-γand IL-17 responses,when cocutured with chlamydial antigen-primed CD4+T cells,than CD11bhi LDCs.Furthermore,the blockade of PD1 in the culture of CD4+T cells with either CD103+or CD11bhi LDCs enhanced production of IFN-γand IL-17.In conclusion,our data provide direct evidence that CD103+LDCs are more potent in promoting Th1/Th17 immunity to chlamydial lung infection than CD11bhi LDCs.