A new method for detecting the crust tilt tides with a folded pendulum is presented. The principle of the folded pendulum and the displacement transducer together with the recording system are introduced. The prelimin...A new method for detecting the crust tilt tides with a folded pendulum is presented. The principle of the folded pendulum and the displacement transducer together with the recording system are introduced. The preliminary experimental result shows that the folded pendulum is very sensitive to the tilt tides.展开更多
Coronitic microstructures have been used to interpret the late-stage solidification history of igneous rocks and to constrain the corresponding chemical and/or physical changes. Coronas with three shells were also rec...Coronitic microstructures have been used to interpret the late-stage solidification history of igneous rocks and to constrain the corresponding chemical and/or physical changes. Coronas with three shells were also recognized in the Miaowan olivine norite, Yangtze Craton, South China. In our study, orthopyroxene intergrowth with vermicular magnetite in the inner shell is in optical continuity with magnetite-free orthopyroxene in the middle shell. In the outer shell of brown amphibole remaining magnetite-free orthopyroxene inclusions sporadically occur. Meanwhile Mg# values of orthopyroxene(76–80) in the inner and middle shells are basically consistent with olivine(78–81). In this paper, we propose a multi-stage genetic model for the formation of coronas in the Miaowan olivine norite. In the first stage, the magnetite-free orthopyroxene shell formed through reaction between primocrystal olivine with the residual Si-rich melt at 990–1 053 ℃ and 6.2–6.5 kbar. In the second stage, the orthopyroxene-magnetite symplectite shell formed when primocrystal olivine reacted with the late-stage residual Fe-rich melt promoted by high oxygen fugacity condition at 927–1 035 ℃ and 6.0–6.5 kbar. In the third stage, the brown amphibole shell formed as the presence of residual hydrous melt and replaced the middle shell at 821–900 ℃ and 5.5–6.0 kbar.展开更多
A sticky-flare gold nanoparticle probe(AuNP-probe)is designed by the combination of locked nucleic acid functionalized silencing of microRNA technology for intracellular microRNA-21(miRNA-21)sensitively detecting,fluo...A sticky-flare gold nanoparticle probe(AuNP-probe)is designed by the combination of locked nucleic acid functionalized silencing of microRNA technology for intracellular microRNA-21(miRNA-21)sensitively detecting,fluorescence imaging,localizing and silencing.The limit of detection is as low as 0.01 n M.Overexpressed miRNA-21 in cancer cells serves as endogenous drug release stimuli to trigger the release of probe-loaded doxorubicin(Dox),which soon translocates into cell nuclei.This multifunctional Dox-loaded AuNP-probe(Dox-AuNP-probe)could induce cancer cell apoptosis effectively through the synergistic effect of gene silencing and chemotherapy.This Dox-AuNP-probe exhibits superior drug potency compared to free Dox molecules,with a cell inhibition rate of 57%(but only 20%for Dox)to wild-type cancer cells and 30%(but 0%for Dox)to drug-resistent cancer cells after 72 h,and this strategy not only has the function of sensing,but also can effectively bypass drug resistance.In MCF-7 xenograft tumor-bearing mice,the Dox-AuNP-probes show greater inhibition for tumor tissues than miRNA-21 targeted AuNP-probes(Targeting-AuNP-probe)or free Dox molecules.Therefore,the Dox-AuNP-probe represents a promising nanotheranostic platform for future applications in cancer molecular imaging and therapy,especially providing a potential strategy to treat resistant cancers.展开更多
文摘A new method for detecting the crust tilt tides with a folded pendulum is presented. The principle of the folded pendulum and the displacement transducer together with the recording system are introduced. The preliminary experimental result shows that the folded pendulum is very sensitive to the tilt tides.
基金financially supported by the National Key Research and the Development Program of China (No. 2016YFC0600502)the National Natural Science Foundation of China (No. 41502046)the Geological Survey Project of China (No. DD20160030)
文摘Coronitic microstructures have been used to interpret the late-stage solidification history of igneous rocks and to constrain the corresponding chemical and/or physical changes. Coronas with three shells were also recognized in the Miaowan olivine norite, Yangtze Craton, South China. In our study, orthopyroxene intergrowth with vermicular magnetite in the inner shell is in optical continuity with magnetite-free orthopyroxene in the middle shell. In the outer shell of brown amphibole remaining magnetite-free orthopyroxene inclusions sporadically occur. Meanwhile Mg# values of orthopyroxene(76–80) in the inner and middle shells are basically consistent with olivine(78–81). In this paper, we propose a multi-stage genetic model for the formation of coronas in the Miaowan olivine norite. In the first stage, the magnetite-free orthopyroxene shell formed through reaction between primocrystal olivine with the residual Si-rich melt at 990–1 053 ℃ and 6.2–6.5 kbar. In the second stage, the orthopyroxene-magnetite symplectite shell formed when primocrystal olivine reacted with the late-stage residual Fe-rich melt promoted by high oxygen fugacity condition at 927–1 035 ℃ and 6.0–6.5 kbar. In the third stage, the brown amphibole shell formed as the presence of residual hydrous melt and replaced the middle shell at 821–900 ℃ and 5.5–6.0 kbar.
基金This work was supported by the Natural Science Foundation of Shandong Province(ZR2015BM024)“Shandong Province Tai-Shan Program”,China Scholarship Council(CSC)scholarship to Dr.Hong,and the National Natural Science Foundation of China(21729501).
文摘A sticky-flare gold nanoparticle probe(AuNP-probe)is designed by the combination of locked nucleic acid functionalized silencing of microRNA technology for intracellular microRNA-21(miRNA-21)sensitively detecting,fluorescence imaging,localizing and silencing.The limit of detection is as low as 0.01 n M.Overexpressed miRNA-21 in cancer cells serves as endogenous drug release stimuli to trigger the release of probe-loaded doxorubicin(Dox),which soon translocates into cell nuclei.This multifunctional Dox-loaded AuNP-probe(Dox-AuNP-probe)could induce cancer cell apoptosis effectively through the synergistic effect of gene silencing and chemotherapy.This Dox-AuNP-probe exhibits superior drug potency compared to free Dox molecules,with a cell inhibition rate of 57%(but only 20%for Dox)to wild-type cancer cells and 30%(but 0%for Dox)to drug-resistent cancer cells after 72 h,and this strategy not only has the function of sensing,but also can effectively bypass drug resistance.In MCF-7 xenograft tumor-bearing mice,the Dox-AuNP-probes show greater inhibition for tumor tissues than miRNA-21 targeted AuNP-probes(Targeting-AuNP-probe)or free Dox molecules.Therefore,the Dox-AuNP-probe represents a promising nanotheranostic platform for future applications in cancer molecular imaging and therapy,especially providing a potential strategy to treat resistant cancers.
