We have compiled eight promising strategies for enhancing the specificity and selectivity of nanozymes,as depicted in the comprehensive summary above.Enzymes exhibit intricate and sophisticated structures,including su...We have compiled eight promising strategies for enhancing the specificity and selectivity of nanozymes,as depicted in the comprehensive summary above.Enzymes exhibit intricate and sophisticated structures,including substrate channels and active sites,which can inform the design of nanozymes.Replication of these structural features and the application of facet engineering/doping techniques can significantly enhance the catalytic specificity of nanozymes.Alternatively,the use of Molecularly Imprinted Polymers(MiPs)to coat nanozymes represents an effective approach to impart substrate specificity.Furthermore,several straightforward stopgap strategies have been devised to improve nanozyme specificity for analytical applications,such as the integration of biorecognition elements and nanozyme sensor arrays through surface modification.展开更多
基金This work was supported by National Key R&D Program of China(2021YFF1200700 and 2019YFA0709200)National Natural Science Foundation of China grant(22374071)+4 种基金Jiangsu Provincial Key R&D Program(BE2022836)CAS Interdisciplinary Innovation Team(JCTD-2020-08)PAPD Program,State Key Laboratory of Analytical Chemistry for Life Science(5431ZZXM2306)NMPA Key Laboratory for Biomedical Optics(20240001)Fundamental Research Funds for the Central Universities(021314380228)。
文摘We have compiled eight promising strategies for enhancing the specificity and selectivity of nanozymes,as depicted in the comprehensive summary above.Enzymes exhibit intricate and sophisticated structures,including substrate channels and active sites,which can inform the design of nanozymes.Replication of these structural features and the application of facet engineering/doping techniques can significantly enhance the catalytic specificity of nanozymes.Alternatively,the use of Molecularly Imprinted Polymers(MiPs)to coat nanozymes represents an effective approach to impart substrate specificity.Furthermore,several straightforward stopgap strategies have been devised to improve nanozyme specificity for analytical applications,such as the integration of biorecognition elements and nanozyme sensor arrays through surface modification.
