Multi Parameter Adaptive Estimation of Reaction-Diffusion Equation

This study addresses the problem of parameter estimation for a one-dimensional reaction-diffusion equation, involving both unknown domain parameters and unknown boundary parameters. The proposed approach utilizes the least-squares method to design an adaptive law for parameter estimation. The convergence analysis demonstrates that under persistent excitation conditions, the adaptive law converges exponentially to zero, indicating that the estimated parameters converge exponentially to their true values. Numerical simulations confirm the effectiveness. Furthermore, it is shown that within a certain range of the reaction coefficient, the auxiliary system acts as a state observer, providing an accurate estimate of the system state at an exponential rate. .

Genetic Variation of the VP1 Gene of the Virulent Duck Hepatitis A Virus Type 1(DHAV-1) Isolates in Shandong Province of China

To investigate the relationship of the variation of virulence and the external capsid proteins of the pandemic duck hepatitis A virus type 1(DHAV-1) isolates,the virulence,cross neutralization assays and the complete sequence of the virion protein 1(VP1) gene of nine virulent DHAV-1 strains,which were isolated from infected ducklings with clinical symptoms in Shandong province of China in 2007-2008,were tested.The fifth generation duck embryo allantoic liquids of the 9 isolates were tested on 12-day-old duck embryos and on 7-day-old ducklings for the median embryonal lethal doses(ELD 50 s) and the median lethal doses(LD 50 s),respectively.The results showed that the ELD 50 s of embryonic duck eggs of the 9 DHAV-1 isolates were between 1.9 × 10 6 /mL to 1.44 × 10 7 /mL,while the LD 50 s were 2.39 × 10 5 /mL to 6.15 × 10 6 /mL.Cross-neutralization tests revealed that the 9 DHAV-1 isolates were completely neutralized by the standard serum and the hyperimmune sera against the 9 DHAV-1 isolates,respectively.Compared with other virulent,moderate virulent,attenuated vaccine and mild strains,the VP1 genes of the 9 strains shared 89.8%-99.7% similarity at the nucleotide level and 92.4%-99.6% at amino acid level with other DHAV-1 strains.There were three hypervariable regions at the C-terminus(aa 158-160,180-193 and 205-219) and other variable points in VP1 protein,but which didn't cause virulence of DHAV-1 change.

A new species in the genus Malcus Stål(Hemiptera:Heteroptera:Malcidae)from China based on morphological and molecular data

Morphological and molecular data confirm a new species in genus Malcus from Xizang,China.Malcus zhengi sp.nov.is described and illustrated.Photos and illustrations of the adult,critical morphological characteristics and pygophore are provided.

Clinicopathological analysis of solitary fibrous tumor

Objective:The aim of this study was to investigate the clinicopathologic characteristics,diagnosis and differential diagnosis,molecular genetics,treatment and prognosis of solitary fibrous tumor(SFT).Methods:The clinicopathological manifestations were analyzed retrospectively in 22 patients with surgically confirmed SFT.Results:There were 12 male patients and 10 female patients,with the age range 33-67(mean 48.62) years.The SFTs originated from different from parts of the body,including 13 in the chest,2 in the lungs,3 in the abdomen,1 in the lumbosacral area,2 in the pelvis,and 1 in the left shoulder.There were 19 benign and 3 malignant tumors.Major clinical presentations were local masses and compression symptoms.Microscopy:the tumor was composed of areas of alternating hypercellularity and hypocellularity.The tumor cells were spindle to short-spindle shaped and arranged in fascicular or storiform pattern and hemangiopericytoma-like structure was presented.Immunohistochemically,Vimentin positive rate was 100%(22/22),Bcl-2 positive rate was 95.5%(21/22),CD99 positive rate was 86.4%(19/22),CD34 positive rate was 81.8(18/22),focally positive for P53,as well as negative CK,S100 and Desmin.Ki67 labelling index was 2%-30%.Conclusion:SFT is a rare tumor which may be found in various parts of human body.SFT mostly is a benign tumor,but a few could be malignant.Its diagnosis mainly rely on its morphologic features and immunohistochemical profiles.The major treatment is to completely resect it by operation and long-term clinical follow-up is necessary.

用于不稳定原子核研究的共线激光谱仪研制进展

不稳定原子核的基本性质是研究核结构的重要探针之一,有助于我们理解丰中子/丰质子核中出现的新奇物理现象,也是检验和发展核理论模型的重要依据.利用精密激光谱学技术测量核外电子的超精细结构光谱,可以精确提取不稳定原子核基态和长寿命同核异能态的自旋、磁矩、电四极矩和电荷半径等多个基本性质.本文简单介绍了国际上激光谱学技术的发展现状和超精细结构光谱的测量原理.在此基础上,详细介绍了在我国研制的基于荧光探测的共线激光谱系统及近期的优化升级现状.通过测量Ti原子和Ca离子的高分辨共振谱,有效验证了共线激光谱设备的整体性能.最后,结合我国现有和发展中放射性核束装置的物理目标,提出进一步优化升级激光谱技术,提高其分辨率和灵敏度,并用于不稳定核研究的计划.

康柏西普不同玻璃体腔注射方案治疗湿性年龄相关性黄斑变性的疗效及安全性比较

目的:比较康柏西普3+PRN和3+Q3M注射方案治疗湿性年龄相关性黄斑变性(AMD)的疗效及安全性。方法:前瞻性临床研究。选取2018年8月至2019年8月在山东大学齐鲁医院眼科确诊的湿性AMD患者106例(106眼),所有患眼均可见黄斑区脉络膜新生血管(CNV)渗漏病灶。采用国际标准小数视力表检查最佳矫正视力(BCVA),统计时换算为最小分辨角对数视力(LogMAR),应用光学相干断层扫描(OCT)测量中心视网膜厚度(CRT)。所有患眼玻璃体腔注射康柏西普0.5 mg,其中55只眼每个月注射1针,连续3针后,延长期按需给药(3+PRN);51只眼每个月注射1针,连续3针后,延长期每3个月注射1次(3+Q3M)。开始治疗后第1、2周以及每个月行常规视力、眼压和OCT检查,每3个月行荧光素眼底血管造影检查,观察所有患者治疗前后患眼BCVA、CRT及CNV病灶渗漏面积的变化及术后不良反应。采用重复测量方差分析、卡方检验进行数据比较。结果:治疗1、3、6、9、12个月后,3+PRN组和3+Q3M组患眼平均BCVA均较治疗前改善(3+PRN组:t=7.202、11.178、9.914、9.869、10.587,均P<0.001;3+Q3M组:t=5.548、9.780、9.358、11.884、11.622,均P<0.001),平均CRT均较治疗前降低(3+PRN组:t=12.28、17.041、17.615、15.739、16.171,均P<0.001;3+Q3M组:t=10.221、15.598、16.297、16.984、17.275,均P<0.001),差异均有统计学意义。其中治疗9、12个月后3+Q3M组患眼BCVA明显高于3+PRN组,差异有统计学意义(t=2.304,P=0.023;t=2.058,P=0.042);治疗9、12个月后3+Q3M组患眼平均CRT明显低于3+PRN组,差异有统计学意义(t=2.032,P=0.045;t=2.092,P=0.039)。治疗12个月时,FFA、ICGA检查发现3+PRN组31眼(56%)、3+Q3M组32眼(63%)渗漏完全消失,3+PRN组18眼(33%)、3+Q3M组15眼(29%)渗漏减轻,3+PRN组6眼(11%)、3+Q3M组4眼(8%)渗漏面积不变或扩大,2组比较差异无统计学意义。随访期间均未见与治疗相关的严重眼部并发症及全身严重不良反应发生。结论:康柏西普3+PRN与3+Q3M治疗方案均为治疗湿性AMD的有效方法,但在视力提高、降低黄斑CRT厚度方面,3+Q3M治疗方案更为有效。