The safety and antimicrobial efficacy of Ethyl lauroyl arginate HCI while using as a preservative have been introduced. Meanwhile the antimicrobial mechanism, the minimal inhibitory concentration and the stability to ...The safety and antimicrobial efficacy of Ethyl lauroyl arginate HCI while using as a preservative have been introduced. Meanwhile the antimicrobial mechanism, the minimal inhibitory concentration and the stability to heat and pH range of ethyl lauroyl arginate HCI have been introduced. The new preservatives have been developed, they are the compounds containing ethyl lauroyl arginate HCI. The high efficacy of antimicrobial of Ethyl lauroyl arginate HCI series products ha been described while added into the formulations of amino acid shampoo and toner. It has been proved that ethyl lauroyl arginate HCI series products can be the optimized option for the alternative of traditional preservatives for cosmetic products.展开更多
Acyl-CoA synthetase long chain family member 5(ACSL5),is a member of the acyl-CoA synthetases(ACSs)family that activates long chain fatty acids by catalyzing the synthesis of fatty acyl-CoAs.The dysregulation of ACSL5...Acyl-CoA synthetase long chain family member 5(ACSL5),is a member of the acyl-CoA synthetases(ACSs)family that activates long chain fatty acids by catalyzing the synthesis of fatty acyl-CoAs.The dysregulation of ACSL5 has been reported in some cancers,such as glioma and colon cancers.However,little is known about the role of ACSL5 in acute myeloid leukemia(AML).We found that the expression of ACSL5 was higher in bone marrow cells from AML patients compared with that from healthy donors.ACSL5 level could serve as an independent prognostic predictor of the overall survival of AML patients.In AML cells,the ACSL5 knockdown inhibited cell growth both in vitro and in vivo.Mechanistically,the knockdown of ACSL5 suppressed the activation of the Wnt/β-catenin pathway by suppressing the palmitoylation modification of Wnt3a.Additionally,triacsin c,a pan-ACS family inhibitor,inhibited cell growth and robustly induced cell apoptosis when combined with ABT-199,the FDA approved BCL-2 inhibitor for AML therapy.Our results indicate that ACSL5 is a potential prognosis marker for AML and a promising pharmacological target for the treatment of molecularly stratified AML.展开更多
This paper considers the discrete-time GeoX/G/1 queueing model with unreliable service station and multiple adaptive delayed vacations from the perspective of reliability research. Following problems will be discussed...This paper considers the discrete-time GeoX/G/1 queueing model with unreliable service station and multiple adaptive delayed vacations from the perspective of reliability research. Following problems will be discussed： 1） The probability that the server is in a ＂generalized busy period＂ at time n; 2） The probability that the service station is in failure at time n, i.e., the transient unavailability of the service station, and the steady state unavailability of the service station; 3） The expected number of service station failures during the time interval （0, hi, and the steady state failure frequency of the service station; 4） The expected number of service station breakdowns in a server＇s ＂generalized busy period＂. Finally, the authors demonstrate that some common discrete-time queueing models with unreliable service station are special cases of the model discussed in this paper.展开更多
文摘The safety and antimicrobial efficacy of Ethyl lauroyl arginate HCI while using as a preservative have been introduced. Meanwhile the antimicrobial mechanism, the minimal inhibitory concentration and the stability to heat and pH range of ethyl lauroyl arginate HCI have been introduced. The new preservatives have been developed, they are the compounds containing ethyl lauroyl arginate HCI. The high efficacy of antimicrobial of Ethyl lauroyl arginate HCI series products ha been described while added into the formulations of amino acid shampoo and toner. It has been proved that ethyl lauroyl arginate HCI series products can be the optimized option for the alternative of traditional preservatives for cosmetic products.
基金supported by the key international cooperation projects of the National Natural Science Foundation of China(No.81820108004)the major projects of the Zhejiang Provincial Department of Science and Technology(No.2021C03123)the Pediatric Leukemia Diagnosis and Therapeutic Technology Research Center of Zhejiang Province(No.JBZX-201904).
文摘Acyl-CoA synthetase long chain family member 5(ACSL5),is a member of the acyl-CoA synthetases(ACSs)family that activates long chain fatty acids by catalyzing the synthesis of fatty acyl-CoAs.The dysregulation of ACSL5 has been reported in some cancers,such as glioma and colon cancers.However,little is known about the role of ACSL5 in acute myeloid leukemia(AML).We found that the expression of ACSL5 was higher in bone marrow cells from AML patients compared with that from healthy donors.ACSL5 level could serve as an independent prognostic predictor of the overall survival of AML patients.In AML cells,the ACSL5 knockdown inhibited cell growth both in vitro and in vivo.Mechanistically,the knockdown of ACSL5 suppressed the activation of the Wnt/β-catenin pathway by suppressing the palmitoylation modification of Wnt3a.Additionally,triacsin c,a pan-ACS family inhibitor,inhibited cell growth and robustly induced cell apoptosis when combined with ABT-199,the FDA approved BCL-2 inhibitor for AML therapy.Our results indicate that ACSL5 is a potential prognosis marker for AML and a promising pharmacological target for the treatment of molecularly stratified AML.
基金supported in part by the National Natural Science Foundation of China under Grant Nos. 71171138,70871084the Specialized Research Fund for the Doctoral Program of Higher Education of China under Grant No.200806360001
文摘This paper considers the discrete-time GeoX/G/1 queueing model with unreliable service station and multiple adaptive delayed vacations from the perspective of reliability research. Following problems will be discussed： 1） The probability that the server is in a ＂generalized busy period＂ at time n; 2） The probability that the service station is in failure at time n, i.e., the transient unavailability of the service station, and the steady state unavailability of the service station; 3） The expected number of service station failures during the time interval （0, hi, and the steady state failure frequency of the service station; 4） The expected number of service station breakdowns in a server＇s ＂generalized busy period＂. Finally, the authors demonstrate that some common discrete-time queueing models with unreliable service station are special cases of the model discussed in this paper.
