The Qinling-Qilian connection zone(QQCZ)is a key area to reveal the relationship and to make a link of the North Qinling and the North Qilian orogens,China.Here we present U-Pb dating data of detrital zircons from fou...The Qinling-Qilian connection zone(QQCZ)is a key area to reveal the relationship and to make a link of the North Qinling and the North Qilian orogens,China.Here we present U-Pb dating data of detrital zircons from four sedimentary/metasedimentary rocks in the QQCZ and the southwestern North China Block(NCB)and detailed regional structural data.Three episodes of fold deformation(D1,D2 and D3)are distinguished in the QQCZ,with the former two occurred during the early Paleozoic.The D1 deformation is mainly characterized by regionally penetrative schistosity and some residual rootless intrafolial folds due to the intensive superpositions by the subsequent D2 and D3 deformations.The D2 deformation characterized by tight folds,associated axial plane foliations and crenulation lineations indicates a stress field characterized by NNE-SSW-directed compression,which may be induced by the collision between the NCB and the southern blocks.The D3 deformation which might occur during the Mesozoic is marked by upright open folds and kink bands.The similarity of the detrital zircon age spectra of the Huluhe Group in the North Qilian Orogen and the Erlangping Group in the North Qinling Orogen suggests that the two groups have similar provenance,which may indicate that the North Qilian Orogen corresponded to the North Qinling Orogen in a regional tectonic framework.In addition,the remarkable age peak at^435 Ma of the detrital zircon age spectrum of the Duanjiaxia Formation in the southwestern NCB indicates that this formation obtained the provenance of the North Qilian and North Qinling orogens,which may be generated by the collage of the southwestern NCB and the QQCZ during the Late Ordovician-Early Silurian.Based on structural,detrital zircon and metamorphic data,we suggest that the North Qilian and North Qinling orogens underwent similar evolution during the early Paleozoic due to the closure of the North Qilian and the Kuanping oceans which located at the northern boundary of the Proto-Tethys Ocean.展开更多
Ginsenosides are a series of glycosylated triterpenoids which belong to protopanaxadiol(PPD)-,protopanaxatriol(PPT)-,ocotillol(OCT)-and oleanane(OA)-type saponins known as active compounds of Panax genus.They are accu...Ginsenosides are a series of glycosylated triterpenoids which belong to protopanaxadiol(PPD)-,protopanaxatriol(PPT)-,ocotillol(OCT)-and oleanane(OA)-type saponins known as active compounds of Panax genus.They are accumulated in plant roots,stems,leaves,and flowers.The content and composition of ginsenosides are varied in different ginseng species,and in different parts of a certain plant.In this review,we summarized the representative saponins structures,their distributions and the contents in nearly 20 Panax species,and updated the biosynthetic pathways of ginsenosides focusing on enzymes responsible for structural diversified ginsenoside biosynthesis.We also emphasized the transcription factors in ginsenoside biosynthesis and non-coding RNAs in the growth of Panax genus plants,and highlighted the current three major biotechnological applications for ginsenosides production.This review covered advances in the past four decades,providing more clues for chemical discrimination and assessment on certain ginseng plants,new perspectives for rational evaluation and utilization of ginseng resource,and potential strategies for production of specific ginsenosides.展开更多
An expressed sequence tag(EST)obtained from a subtractive-suppression hybridization cDNA library constructed using Catharanthus roseus cell line C_(20)hi and its parental cell line C_(20)D was used to clone a ful-leng...An expressed sequence tag(EST)obtained from a subtractive-suppression hybridization cDNA library constructed using Catharanthus roseus cell line C_(20)hi and its parental cell line C_(20)D was used to clone a ful-length cytochrome P450 cDNA of cyp71d1.The encoded polypeptide contained 507 amino acids with 39-56% identity to other CYP7ID subfamily members at the.amino acid level.Expression characteristics of cyp71d1 were determined using semi-quantitative RT-PCR.The cyp71d1 transcript was expressed in all three cell lines with the highest level in the cell line C_(20)hi.In the mature C.roseus plant,the cyp71d1 cDNA was highly expressed in petals,roots and stems,but very weakly expressed in young leaves.Its transcription level increased with the development of flowers.2,4-D could down-regulate the transcription of cyp71d1,as did KT,but only to a minor degree.Neither light nor yeast elicitor could induce the transcription of cyp71d1.展开更多
Cancer occurrence and development are closely related to increased lipid produc-tion and glucose consumption.Lipids are the basic component of the cell membrane and play a significant role in cancer cell processes suc...Cancer occurrence and development are closely related to increased lipid produc-tion and glucose consumption.Lipids are the basic component of the cell membrane and play a significant role in cancer cell processes such as cell-to-cell recognition,signal transduction,and energy supply,which are vital for cancer cell rapid proliferation,invasion,and metastasis.Sterol regulatory element-binding transcription factor 1(SREBP1)is a key transcription factor regulating the expression of genes related to cholesterol biosynthesis,lipid homeostasis,and fatty acid synthesis.In addition,SREBP1 and its upstream or downstream target genes are implicated in various metabolic diseases,particularly cancer.However,no review of sREBP1 in cancer biology has yet been published.Herein,we summarized the roles and mechanisms of SREBP1 biological processes in cancer cells,including SREBP1 modification,lipid metabolism and reprogramming,glucose and mitochondrial metabolism,immunity,and tumor microenvi-ronment,epithelial-mesenchymal transition,cell cycle,apoptosis,and ferroptosis.Addition-ally,we discussed the potential role of SREBP1 in cancer prognosis,drug response such as drug sensitivity to chemotherapy and radiotherapy,and the potential drugs targeting SREBP1 and its corresponding pathway,elucidating the potential clinical application based on SREBP1 and its corresponding signal pathway.展开更多
基金funded by the National Natural Science Foundation of China(Gant Nos.41702206,41602042 and 41502042)National Key Research and Development Program of China(Grant No.2016YFC0601002)+1 种基金supported by Aoshan Talents Program of Qingdao National Laboratory for Marine Science and Technology(Grant No.2015ASTP-0S10)Taishan Scholar Program to Prof.Sanzhong Li。
文摘The Qinling-Qilian connection zone(QQCZ)is a key area to reveal the relationship and to make a link of the North Qinling and the North Qilian orogens,China.Here we present U-Pb dating data of detrital zircons from four sedimentary/metasedimentary rocks in the QQCZ and the southwestern North China Block(NCB)and detailed regional structural data.Three episodes of fold deformation(D1,D2 and D3)are distinguished in the QQCZ,with the former two occurred during the early Paleozoic.The D1 deformation is mainly characterized by regionally penetrative schistosity and some residual rootless intrafolial folds due to the intensive superpositions by the subsequent D2 and D3 deformations.The D2 deformation characterized by tight folds,associated axial plane foliations and crenulation lineations indicates a stress field characterized by NNE-SSW-directed compression,which may be induced by the collision between the NCB and the southern blocks.The D3 deformation which might occur during the Mesozoic is marked by upright open folds and kink bands.The similarity of the detrital zircon age spectra of the Huluhe Group in the North Qilian Orogen and the Erlangping Group in the North Qinling Orogen suggests that the two groups have similar provenance,which may indicate that the North Qilian Orogen corresponded to the North Qinling Orogen in a regional tectonic framework.In addition,the remarkable age peak at^435 Ma of the detrital zircon age spectrum of the Duanjiaxia Formation in the southwestern NCB indicates that this formation obtained the provenance of the North Qilian and North Qinling orogens,which may be generated by the collage of the southwestern NCB and the QQCZ during the Late Ordovician-Early Silurian.Based on structural,detrital zircon and metamorphic data,we suggest that the North Qilian and North Qinling orogens underwent similar evolution during the early Paleozoic due to the closure of the North Qilian and the Kuanping oceans which located at the northern boundary of the Proto-Tethys Ocean.
基金supported by National Natural Science Foundation of China(No.81673540,No.81530096)Natural Science Foundation of Shanghai(No.16ZR1434100,China)Shanghai local Science and Technology Development Fund Program guided by the Central Government(YDZX20203100002948,China)
文摘Ginsenosides are a series of glycosylated triterpenoids which belong to protopanaxadiol(PPD)-,protopanaxatriol(PPT)-,ocotillol(OCT)-and oleanane(OA)-type saponins known as active compounds of Panax genus.They are accumulated in plant roots,stems,leaves,and flowers.The content and composition of ginsenosides are varied in different ginseng species,and in different parts of a certain plant.In this review,we summarized the representative saponins structures,their distributions and the contents in nearly 20 Panax species,and updated the biosynthetic pathways of ginsenosides focusing on enzymes responsible for structural diversified ginsenoside biosynthesis.We also emphasized the transcription factors in ginsenoside biosynthesis and non-coding RNAs in the growth of Panax genus plants,and highlighted the current three major biotechnological applications for ginsenosides production.This review covered advances in the past four decades,providing more clues for chemical discrimination and assessment on certain ginseng plants,new perspectives for rational evaluation and utilization of ginseng resource,and potential strategies for production of specific ginsenosides.
基金This study was supported by grants from the National Natural Science Foundation of China(No.30200358)the Doctorate Specialized Research Fund from China Ministry of Education(20070268008).
文摘An expressed sequence tag(EST)obtained from a subtractive-suppression hybridization cDNA library constructed using Catharanthus roseus cell line C_(20)hi and its parental cell line C_(20)D was used to clone a ful-length cytochrome P450 cDNA of cyp71d1.The encoded polypeptide contained 507 amino acids with 39-56% identity to other CYP7ID subfamily members at the.amino acid level.Expression characteristics of cyp71d1 were determined using semi-quantitative RT-PCR.The cyp71d1 transcript was expressed in all three cell lines with the highest level in the cell line C_(20)hi.In the mature C.roseus plant,the cyp71d1 cDNA was highly expressed in petals,roots and stems,but very weakly expressed in young leaves.Its transcription level increased with the development of flowers.2,4-D could down-regulate the transcription of cyp71d1,as did KT,but only to a minor degree.Neither light nor yeast elicitor could induce the transcription of cyp71d1.
基金supported by the National Natural Science Foundation of China(No.81802371)China Scholarship Council(No.201908330151)+4 种基金Zhejiang Provincial Natural Science Foundation(China)(No.LQ17H160009)Zhejiang Province Medical Science and Technology Project(China)(No.2018KY108,2021RC117)Zhejiang Traditional Chinese Medicine Scientific Research Fund Project(China)(No.2022ZB230)Hangzhou Health Science and Technology Major Project(Zhejiang,China)(No.Z20230119)Hangzhou Agricultural and Social Development Scientific Research Independent Application Project(Zhejiang,China)(No.20191203B22).
文摘Cancer occurrence and development are closely related to increased lipid produc-tion and glucose consumption.Lipids are the basic component of the cell membrane and play a significant role in cancer cell processes such as cell-to-cell recognition,signal transduction,and energy supply,which are vital for cancer cell rapid proliferation,invasion,and metastasis.Sterol regulatory element-binding transcription factor 1(SREBP1)is a key transcription factor regulating the expression of genes related to cholesterol biosynthesis,lipid homeostasis,and fatty acid synthesis.In addition,SREBP1 and its upstream or downstream target genes are implicated in various metabolic diseases,particularly cancer.However,no review of sREBP1 in cancer biology has yet been published.Herein,we summarized the roles and mechanisms of SREBP1 biological processes in cancer cells,including SREBP1 modification,lipid metabolism and reprogramming,glucose and mitochondrial metabolism,immunity,and tumor microenvi-ronment,epithelial-mesenchymal transition,cell cycle,apoptosis,and ferroptosis.Addition-ally,we discussed the potential role of SREBP1 in cancer prognosis,drug response such as drug sensitivity to chemotherapy and radiotherapy,and the potential drugs targeting SREBP1 and its corresponding pathway,elucidating the potential clinical application based on SREBP1 and its corresponding signal pathway.
