Wettability Gradient-Induced Diode:MXene-Engineered Membrane for Passive-Evaporative Cooling

Thermoregulatory textiles,leveraging high-emissivity structural materials,have arisen as a promising candidate for personal cooling management;however,their advancement has been hindered by the underperformed water moisture transportation capacity,which impacts on their thermophysiological comfort.Herein,we designed a wettability-gradient-induced-diode(WGID)membrane achieving by MXene-engineered electrospun technology,which could facilitate heat dissipation and moisture-wicking transportation.As a result,the obtained WGID membrane could obtain a cooling temperature of 1.5℃ in the“dry”state,and 7.1℃ in the“wet”state,which was ascribed to its high emissivity of 96.40%in the MIR range,superior thermal conductivity of 0.3349 W m^(-1) K^(-1)(based on radiation-and conduction-controlled mechanisms),and unidirectional moisture transportation property.The proposed design offers an approach for meticulously engineering electrospun membranes with enhanced heat dissipation and moisture transportation,thereby paving the way for developing more efficient and comfortable thermoregulatory textiles in a high-humidity microenvironment.

Bioinspired All‑Fibrous Directional Moisture‑Wicking Electronic Skins for Biomechanical Energy Harvesting and All‑Range Health Sensing

Electronic skins can monitor minute physiological signal variations in the human skins and represent the body’s state,showing an emerging trend for alternative medical diagnostics and human-machine interfaces.In this study,we designed a bioinspired directional moisture-wicking electronic skin(DMWES)based on the construction of heterogeneous fibrous membranes and the conductive MXene/CNTs electrospraying layer.Unidirectional moisture transfer was successfully realized by surface energy gradient and push-pull effect via the design of distinct hydrophobic-hydrophilic difference,which can spontaneously absorb sweat from the skin.The DMWES membrane showed excellent comprehensive pressure sensing performance,high sensitivity(maximum sensitivity of 548.09 kPa^(−1)),wide linear range,rapid response and recovery time.In addition,the single-electrode triboelectric nanogenerator based on the DMWES can deliver a high areal power density of 21.6μW m^(−2) and good cycling stability in high pressure energy harvesting.Moreover,the superior pressure sensing and triboelectric performance enabled the DMWES for all-range healthcare sensing,including accurate pulse monitoring,voice recognition,and gait recognition.This work will help to boost the development of the next-generation breathable electronic skins in the applications of AI,human-machine interaction,and soft robots.

Tropoelastin improves adhesion and migration of intra-articular injected infrapatellar fat pad MSCs and reduces osteoarthritis progression

Intra-articular injection of mesenchymal stem cells(MSCs)is a promising strategy for osteoarthritis(OA)treatment.However,more and more studies reveal that the injected MSCs have poor adhesion,migration,and survival in the joint cavity.A recent study shows that tropoelastin(TE)regulates adhesion,proliferation and phenotypic maintenance of MSCs as a soluble additive,indicating that TE could promote MSCs-homing in regenerative medicine.In this study,we used TE as injection medium,and compared it with classic media in MSCs intra-articular injection such as normal saline(NS),hyaluronic acid(HA),and platelet-rich plasma(PRP).We found that TE could effectively improve adhesion,migration,chondrogenic differentiation of infrapatellar fat pad MSCs(IPFP-MSCs)and enhance matrix synthesis of osteoarthritic chondrocytes(OACs)in indirect-coculture system.Moreover,TE could significantly enhance IPFP-MSCs adhesion via activation of integrin β1,ERK1/2 and vinculin(VCL)in vitro.In addition,intra-articular injection of TE-IPFP MSCs suspension resulted in a short-term increase in survival rate of IPFP-MSCs and better histology scores of rat joint tissues.Inhibition of integrin β1 or ERK1/2 attenuated the protective effect of TE-IPFP MSCs suspension in vivo.In conclusion,TE promotes performance of IPFP-MSCs and protects knee cartilage from damage in OA through enhancement of cell adhesion and activation of integrin β1/ERK/VCL pathway.Our findings may provide new insights in MSCs intra-articular injection for OA treatment.