ACU&MOX-DATA:针灸多组学异源数据融合分析平台

本文介绍了名为ACU&MOX-DATA(Acupuncture&moxibustion-deep analysis to treat accurately)的针灸多组学异源数据融合分析网络平台(http://cbcb.cdutcm.edu.cn/ACU&MOX-DATA/)。该平台旨在整合分析针灸相关疾病、临床和实验室获得的异源、多层次数据,其典型特点是在中医理论指导下,收集针灸研究所获得的各种观测指标,通过异源、多层次数据融合分析的方法,实现对针灸学领域关键科学问题的集成分析和可视化解读。本文介绍了该平台目前已有的功能及未来的研究计划。

Dynamic analysis of heat extraction rate by supercritical carbon dioxide in fractured rock mass based on a thermal-hydraulic-mechanics coupled model

Heat production from geothermal reservoirs is a typical heat transfer process involving a cold working fluid contacting a hot rock formation.Compared to the thermal-physical characteristics of water,supercritical CO_(2)(scCO_(2))has a higher heat storage capacity over a wide temperature-pressure range and may be favored as a heat transfer fluid.Singularly characteristic of scCO_(2)-based heat extraction is that the hydraulic-thermal properties of the scCO_(2) vary dramatically and dynamically with the spatial pressure gradient during unsteady-state flow along fracture.This highly nonlinear behavior presents a challenge in the accurate estimation of heat extraction efficiency in scCO_(2)-based EGS.In this paper,a thermal-h ydraulic-mechanical(THM)coupled model is developed by considering deformation of the fractured reservoir,non-Darcy flow and the varying thermal-physical properties of scCO_(2).The proposed model is validated by matching the modeling temperature distribution with published data.The results show that during continuous injection of scCO_(2),the fracture first widens and then narrows,ultimately reopening over the long term.The sequential fracture deformation behaviors are in response to the combined impacts of mechanical compression and thermally-induced deformation.By controlling the injection parameters of the scCO_(2),it is found that the heat extraction rate is positively correlated to its pore pressure or mass flow rate.The heat extraction rate can be significantly enhanced,when the inlet temperature of scCO_(2) is below its critical temperature.As a result,the heat increment recovered per unit mass of scCO_(2) decreases as the hot rock is gradually cooled.Meanwhile,the heat increment recovered per unit mass of scCO_(2) decreases by increasing the inlet temperature of scCO_(2) or its mass flow rate,but increases as the outlet pressure rises.Furthermore,multi-linear regression indicates that controlling the inlet temperature of the scCO_(2) can significantly improve the thermodynamic efficiency of heat extraction.

Targeting Annexin A7 in Hepatocarcinoma Lymphatic Metastasis

Background and objective The rst aim was to measure the expressions of Annexin A7 (Anxa7) at mRNA level and protein level in two mice hepatocarcinoma ascites syngeneic cell

肝硬化并发上消化道出血的临床护理干预策略和效果评估

目的探讨肝硬化并发上消化道出血的临床护理干预策略和效果。方法选取2018年6月-2019年1月到本院接受治疗的98例肝硬化并发上消化道出血患者,随机分为对照组49例(基础护理)与观察组49例(护理干预),比较两组住院时长、止血时长、出血次数及并发症发生率指标。结果治疗结束,观察组在住院时长、止血时长、出血次数及并发症发生率指标上均低于对照组且差异具有统计学意义(P<0.05)。结论护理干预方法可有效改善肝硬化并发上消化道出血患者预后,值得推广使用。

Numerical modeling of contaminant advection impact on hydrodynamic diffusion in a deformable medium

The self-weight of solid waste or machine-rolled compaction can induce or trigger contaminant migration in the landfill.Although the consolidation-induced hydraulic gradient driving solution transport has been extensively investigated,little attention has been paid to ion migration caused by its concentration gradient variation.It is necessary to more precisely predict the multi-stage contaminant transports in deforming porous material.Based on the modified Cam-clay model,the proposed fluid-solid coupled model can simulate the elastoplastic deformation behavior of layered kaolinite and KBr solution transport/sorption,and its modeling results were validated by published laboratory data.The solid-fluid interactions were analyzed by comparing various transport manners of K^(+)and Br^(−)from excess pore pressure generation to dissipation.Results reveal that the consolidation process can accelerate KBr solute advection from the contaminated layer into the uncontaminated layer,and then affects the subsequent diffusion,mechanical dispersion and sorption for K^(+)and Br^(−).The simulations also indicate that consolidation-induced solute transport is time-dependent,and therefore the ion diffusion and mechanical dispersion should receive more attention.

A BBS4 mutation causes autosomal dominant polycystic liver disease

Autosomal dominant polycystic liver disease(ADPLD)refers to a condition characterized by the presence of numerous cholangiocytes-lined and fluid-filled cysts in the liver and the absence of polycystic kidney disease.1 Although patients with ADPLD may be asymptomatic,some patients suffer from abdominal pain,gastroesophageal reflux,and nausea,because of hepatomegaly.