Oxygen(O2)supplementation plays a key role in the treatment of some hypoxia-associated diseases,such as solid tumors,tissue damage,and type-1 diabetes(T1D).Various strategies have been developed to address the hypoxia...Oxygen(O2)supplementation plays a key role in the treatment of some hypoxia-associated diseases,such as solid tumors,tissue damage,and type-1 diabetes(T1D).Various strategies have been developed to address the hypoxia aspect of these diseases,such as hyperbaric O2 and liquid or solid O2-generating materials.Calcium peroxide(CaO2)has been regarded as a promising O2 provider in the fields of re・generative medicine(Chang and Wang,2013)and tumor treatment(Huang et al.,2016)because of good biocompatibility,high O2 content(0.2222 g O2 g 1 CaO2),and longtime O2-releasing capacity.Moreover,as the"solid H2O2",CaO2 can react with water(H2O)and quickly generate H2O2,a common reactive O2 species(ROS),which can result in excellent antibacterial activity and antitumor effects.Here we focused on the applications of CaO2 in the field of bio・medicine and summarized the recent progress on this research(Figure 1).展开更多
Chemodynamic therapy(CDT)is an emerging and promising strategy based on the Fenton or Fenton-like reaction in tumors[1–3].The tumor microenvironment(TME)has the characteristics of low acidity and overexpression of H2...Chemodynamic therapy(CDT)is an emerging and promising strategy based on the Fenton or Fenton-like reaction in tumors[1–3].The tumor microenvironment(TME)has the characteristics of low acidity and overexpression of H2O2[4,5],thus providing favorable conditions for initiating the Fenton or Fenton-like reaction.In CDT,intratumoral H2O2 is decomposed into highly toxic hydroxyl radicals(·OH)through the Fenton or Fenton-like reaction catalyzed by a metal-based nanocatalyst,which will cause irreversible damage to DNA,lipids,and proteins[6,7].展开更多
基金supported by the National Natural Science Foundation of China(31971304,21977024 and 21601046)Natural Science Key Foundation of Hebei Province(B2017201226)
文摘Oxygen(O2)supplementation plays a key role in the treatment of some hypoxia-associated diseases,such as solid tumors,tissue damage,and type-1 diabetes(T1D).Various strategies have been developed to address the hypoxia aspect of these diseases,such as hyperbaric O2 and liquid or solid O2-generating materials.Calcium peroxide(CaO2)has been regarded as a promising O2 provider in the fields of re・generative medicine(Chang and Wang,2013)and tumor treatment(Huang et al.,2016)because of good biocompatibility,high O2 content(0.2222 g O2 g 1 CaO2),and longtime O2-releasing capacity.Moreover,as the"solid H2O2",CaO2 can react with water(H2O)and quickly generate H2O2,a common reactive O2 species(ROS),which can result in excellent antibacterial activity and antitumor effects.Here we focused on the applications of CaO2 in the field of bio・medicine and summarized the recent progress on this research(Figure 1).
基金supported by the National Natural Science Foundation of China(31971304 and 21601046)the Natural Science Key Foundation of Hebei Province(B2017201226)the Doctoral Candidate Innovation Funding Project of Hebei Province(CXZZBS2020022)。
文摘Chemodynamic therapy(CDT)is an emerging and promising strategy based on the Fenton or Fenton-like reaction in tumors[1–3].The tumor microenvironment(TME)has the characteristics of low acidity and overexpression of H2O2[4,5],thus providing favorable conditions for initiating the Fenton or Fenton-like reaction.In CDT,intratumoral H2O2 is decomposed into highly toxic hydroxyl radicals(·OH)through the Fenton or Fenton-like reaction catalyzed by a metal-based nanocatalyst,which will cause irreversible damage to DNA,lipids,and proteins[6,7].
