An increasing number of studies are suggesting that hepatitis B virus(HBV)infection may be associated with an increased risk of not only hepatocellular carcinoma but also gastric cancer(GC).Whether HBV infection can b...An increasing number of studies are suggesting that hepatitis B virus(HBV)infection may be associated with an increased risk of not only hepatocellular carcinoma but also gastric cancer(GC).Whether HBV infection can be a risk factor for GC remains to be explored.In this study,we systematically searched for all eligible literature in 7 databases(China National Knowledge Infrastructure,WanFang,China Science and Technology Journal,PubMed,Cochrane Library,Web of Science and Embase).Eligible studies were required to have a case-control or cohort design.Sixteen studies were included and a meta-analysis was performed using Stata version 17.0.The quality of the included studies was assessed using the Newcastle-Ottawa Scale.The association between HBV infection and risk of GC was quantified by calculating the odds ratio and 95%confidence interval.The proportion of high-quality studies was 87.5%(14/16).The risk of GC was higher when HBV infection was present than when it was not(combined odds ratio 1.29,95%confidence interval 1.16-1.44;I^(2)=62.7%,p<0.001).The results of subgroup analyses were consistent with the main results.In conclusion,this systematic review and meta-analysis identified a positive association between HBV infection and an increased risk of GC.展开更多
文摘An increasing number of studies are suggesting that hepatitis B virus(HBV)infection may be associated with an increased risk of not only hepatocellular carcinoma but also gastric cancer(GC).Whether HBV infection can be a risk factor for GC remains to be explored.In this study,we systematically searched for all eligible literature in 7 databases(China National Knowledge Infrastructure,WanFang,China Science and Technology Journal,PubMed,Cochrane Library,Web of Science and Embase).Eligible studies were required to have a case-control or cohort design.Sixteen studies were included and a meta-analysis was performed using Stata version 17.0.The quality of the included studies was assessed using the Newcastle-Ottawa Scale.The association between HBV infection and risk of GC was quantified by calculating the odds ratio and 95%confidence interval.The proportion of high-quality studies was 87.5%(14/16).The risk of GC was higher when HBV infection was present than when it was not(combined odds ratio 1.29,95%confidence interval 1.16-1.44;I^(2)=62.7%,p<0.001).The results of subgroup analyses were consistent with the main results.In conclusion,this systematic review and meta-analysis identified a positive association between HBV infection and an increased risk of GC.
