Oxygen reduction reaction over Pt-based catalyst is one of the most significant cathode reactions in fuel cells.However,low reserves and high price of Pt have motivated researchers worldwide seeking enhanced utilizati...Oxygen reduction reaction over Pt-based catalyst is one of the most significant cathode reactions in fuel cells.However,low reserves and high price of Pt have motivated researchers worldwide seeking enhanced utilization efficiency and durability by doping non-noble metals to form Pt-based alloy catalysts.Alloying Pt with Co has been recognized as one of the most effective approaches to achieve this goal.PtCo bimetal combination is one of the most promising candidates to synthesize highly efficient catalysts for oxygen reduction reaction(ORR)applications,owing to its relatively more suitable oxygen binding energy for four-electron transfer reactions.Recently,impressive strategies have been developed to fabricate more active and stable PtCo-based multimetallic alloys with tailorable size and morphology.This paper aims to summarize the most recent highlights on the study of the relationship between preparation strategies,morphologies,electroactivities of the PtCo-based catalyst at atomic level and further the relevant reaction mechanism.The challenges and opportunities on the further development of electrocatalysts for fuel cells are included to provide reference for the practical application.展开更多
Proton exchange membrane fuel cell and direct methanol fuel cells have gained more attention due to high-energy density,remarkable conversion efficiency,and low emission.However,their widely practical application was ...Proton exchange membrane fuel cell and direct methanol fuel cells have gained more attention due to high-energy density,remarkable conversion efficiency,and low emission.However,their widely practical application was hindered by the high usage,limited sources,and high price of Pt catalysts.To achieve more cost-effective catalytic systems,PtCu-based multi-metallic nanoparticles are highly efficient for the oxygen reduction reaction(ORR)and methanol oxidation reaction(MOR).The incorporation of non-noble Cu metal can alter the properties of hybrids by forming new facets,planes,edges to promote the cleavage or formation of chemical bonds in catalytic reaction.This is a rapid growing area with numerous contributions from the interdisciplinary areas of nanocatalysis.This paper has summarized the recent progress in the past two years,in synthesizing PtCu-based alloys with various composition and morphologies,and critically discussed the effect of the catalyst preparation method,metal precursor,surfactant,reductant and heating temperature on nanostructure and electronic configuration.The important role of the composition,size,and morphology of PtCu bimetallic catalysts for electro oxidation reactions has been further established for structure-dependency studies.The challenges and perspectives of nanocatalysts for ORR and MOR discussed in this work is to provide further insights into rational design for cost-effective materials for energy.展开更多
Adipic acid is a dicarboxylic acid of great industrial importance,mainly used in the production of nylon-6,6 and polyurethane.The use of nitric acid as an oxidant in the industrial production of adipic acid poses sign...Adipic acid is a dicarboxylic acid of great industrial importance,mainly used in the production of nylon-6,6 and polyurethane.The use of nitric acid as an oxidant in the industrial production of adipic acid poses significant carbon footprint to the environment.Clean adipic acid synthesis methods using a heterogeneous catalyst with H2O2 as oxidant and water as solvent have potential advantages of low catalyst cost,easy synthesis and recovery,cleanness and environmental protection.In this work,hexagonal mesoporous silicate materials were synthesized by a sol–gel method and evaluated for cyclohexanol/cyclohexanone oxidation to adipic acid.The physical and chemical properties of Fe-HMS were characterized by XRD,HR-TEM,BET and UV–Vis.The experimental results showed that Fe-HMS materials show pore sizes ranging from 2–3 nm.W-and Mo-based polyoxometalates were also evaluated and compared to the Fe-based HMS catalysts.To improve the adipic acid yield,the influence of the transition metal as well as the effect of metal loading,reaction temperature and catalyst amount on the catalytic performances of Fe-HMS have been investigated in details.When Si/Fe atomic ratio=100,Fe-HMS catalyst shows the highest activity,with a cyclohexanone conversion of 92.3%and adipic acid selectivity of 29.4%.The reaction pathway of cyclohexanone oxidation was further proposed based on experimental data.展开更多
[ Objective] The research aimed to evaluate vulnerability of the lightning disaster in Guizhou and conduct zoning. [ Method] According to data of the lightning monitoring network and statistical data of the lightning ...[ Objective] The research aimed to evaluate vulnerability of the lightning disaster in Guizhou and conduct zoning. [ Method] According to data of the lightning monitoring network and statistical data of the lightning disaster in Guizhou during 2007 -2012, by combining economy and population situations in 9 cities of Guizhou, 6 indicators were used to assess vulnerability of the lightning disasterCG lightning intensity, strong CG lightning intensity, annual average occurrence frequency of the lightning disaster, GDP per capita, population intensity and casualties frequency. By constructing principal component, determining weighing and comprehensive assessment, vulnerability grade of the lightning disaster in Guizhou was divided. [ Result] Guiyang was extremely high vulnerability zone, high vulnerability zone included Zunyi, Bijie and Liupanshui, moderate vulnerabili- ty zone included Anshun, Tongren and Qianxinan, Qiannan was low vulnerability zone, and Qiandongnan was extremely low vulnerability zone. Vulnerability distribution boundary of the lightning disaster in Guizhou was along northeast to southwest, and vulnerability of the lightning disaster gradually weakened from northwest to southeast. [ Conclusion] The research provided scientific basis for preventing lightning disaster and reducing damage of the lightning disaster.展开更多
Terminal olefins are important building blocks for the industry of biofuels,oligomers,and lubricants production.The industrial processes for production of olefins involving oligomerization of ethylene or cracking of p...Terminal olefins are important building blocks for the industry of biofuels,oligomers,and lubricants production.The industrial processes for production of olefins involving oligomerization of ethylene or cracking of petrochemical waxes have several flaws including low yield and high cost in product separation.Cross-metathesis of bio-derived unsaturated fatty esters and olefins with ethylene(ethenolysis),allows the conversion of sustainable waste biomass to various renewable olefins with much safer,less toxic,sustainable,and zero-CO_(2) emission processes.To our best knowledge,however,a comprehensive summary of key advances in this field(since 2017)is yet to be available,particularly on molecular features of homogeneous and heterogeneous catalysts.This paper presents a critical review on molecular structures of metal complex and oxide catalysts for ethenolysis of olefins and oleochemicals.The influence of cationic centers,coordination conditions,nature of ligands,operating conditions on catalyst performances will be systematically discussed along with relevant reaction mechanism.The key challenges for rational design of coordinated cationic hybrids have been summarized,which will provide insights to technological advancement of large-scale production of oleochemical-derived olefins.展开更多
Microtubule-associated protein Tau is responsible for the stabilization of neuronal microtubules under normal physiological conditions.Much attention has been focused on Tau’s contribution to cognition,but little res...Microtubule-associated protein Tau is responsible for the stabilization of neuronal microtubules under normal physiological conditions.Much attention has been focused on Tau’s contribution to cognition,but little research has explored its role in emotions such as pain,anxiety,and depression.In the current study,we found a significant increase in the levels of p-Tau(Thr231),total Tau,IL-1β,and brain-derived neurotrophic factor(BDNF)on day 7 after complete Freund's adjuvant(CFA)injection;they were present in the vast majority of neurons in the spinal dorsal horn.Microinjection of Mapt-shRNA recombinant adeno-associated virus into the spinal dorsal cord alleviated CFA-induced inflammatory pain and inhibited CFA-induced IL-1βand BDNF upregulation.Importantly,Tau overexpression was sufficient to induce hyperalgesia by increasing the expression of IL-1βand BDNF.Furthermore,the activation of glycogen synthase kinase 3 beta partly contributed to Tau accumulation.These findings suggest that Tau in the dorsal horn could be a promising target for chronic inflammatory pain therapy.展开更多
Serine/arginine-rich splicing factor 7(SRSF7),a known splicing factor,has been revealed to play oncogenic roles in multiple cancers.However,the mechanisms underlying its oncogenic roles have not been well addressed.He...Serine/arginine-rich splicing factor 7(SRSF7),a known splicing factor,has been revealed to play oncogenic roles in multiple cancers.However,the mechanisms underlying its oncogenic roles have not been well addressed.Here,based on N6-methyladenosine(m^(6)A)co-methylation network analysis across diverse cell lines,we find that the gene expression of SRSF7 is positively correlated with glioblastoma(GBM)cell-specific m^(6)A methylation.We then indicate that SRSF7 is a novel m^(6)A regulator,which specifically facilitates the m^(6)A methylation near its binding sites on the mRNAs involved in cell proliferation and migration,through recruiting the methyltransferase complex.Moreover,SRSF7 promotes the proliferation and migration of GBM cells largely dependent on the presence of the m^(6)A methyltransferase.The two m^(6)A sites on the mRNA for PDZ-binding kinase(PBK)are regulated by SRSF7 and partially mediate the effects of SRSF7 in GBM cells through recognition by insulin-like growth factor 2 mRNA-binding protein 2(IGF2BP2).Together,our discovery reveals a novel role of SRSF7 in regulating m^(6)A and validates the presence and functional importance of temporal-and spatial-specific regulation of m^(6)A mediated by RNA-binding proteins(RBPs).展开更多
The incidence rate of anxiety and depression is significantly higher in patients with inflammatory bowel diseases(IBD)than in the general population.The mechanisms underlying dextran sulfate sodium(DSS)-induced depres...The incidence rate of anxiety and depression is significantly higher in patients with inflammatory bowel diseases(IBD)than in the general population.The mechanisms underlying dextran sulfate sodium(DSS)-induced depressive-like behaviors are still unclear.We clarified that IBD mice induced by repeated administration of DSS presented depressive-like behaviors.The paraventricular thalamic nucleus(PVT)was regarded as the activated brain region by the number of c-fos-labeled neurons.RNA-sequencing analysis showed that lipocalin 2(Lcn2)was upregulated in the PVT of mice with DSS-induced depressive behaviors.Upregulating Lcn2 from neuronal activity induced dendritic spine loss and the secreted protein induced chemokine expression and subsequently contributed to microglial activation leading to blood-brain barrier permeability.Moreover,Lcn2 silencing in the PVT alleviated the DSS-induced depressive-like behaviors.The present study demonstrated that elevated Lcn2 in the PVT is a critical factor for DSS-induced depressive behaviors.展开更多
基金supported by the National Natural Science Foundation of China(22008262)Natural Science Foundation of Shandong Province(ZR2020QB187).
文摘Oxygen reduction reaction over Pt-based catalyst is one of the most significant cathode reactions in fuel cells.However,low reserves and high price of Pt have motivated researchers worldwide seeking enhanced utilization efficiency and durability by doping non-noble metals to form Pt-based alloy catalysts.Alloying Pt with Co has been recognized as one of the most effective approaches to achieve this goal.PtCo bimetal combination is one of the most promising candidates to synthesize highly efficient catalysts for oxygen reduction reaction(ORR)applications,owing to its relatively more suitable oxygen binding energy for four-electron transfer reactions.Recently,impressive strategies have been developed to fabricate more active and stable PtCo-based multimetallic alloys with tailorable size and morphology.This paper aims to summarize the most recent highlights on the study of the relationship between preparation strategies,morphologies,electroactivities of the PtCo-based catalyst at atomic level and further the relevant reaction mechanism.The challenges and opportunities on the further development of electrocatalysts for fuel cells are included to provide reference for the practical application.
基金supported by the National Natural Science Foundation(22078365,22008262)the Natural Science Foundation of Shandong Province(ZR2020QB187)+3 种基金the Postdoctoral Research Fun ding of Shand ong Province(201703016)the Qingdao Postdoctoral Research Funding(BY20170210)the"Fundamental Research Funds for the Central Universities"and"the Development Fund of State Key Laboratory of Heavy Oil Processing"(18CX02145A,17CX02017A,20CX02204A)the new faculty start-up funding from the China University of Petroleum(YJ201601058).
文摘Proton exchange membrane fuel cell and direct methanol fuel cells have gained more attention due to high-energy density,remarkable conversion efficiency,and low emission.However,their widely practical application was hindered by the high usage,limited sources,and high price of Pt catalysts.To achieve more cost-effective catalytic systems,PtCu-based multi-metallic nanoparticles are highly efficient for the oxygen reduction reaction(ORR)and methanol oxidation reaction(MOR).The incorporation of non-noble Cu metal can alter the properties of hybrids by forming new facets,planes,edges to promote the cleavage or formation of chemical bonds in catalytic reaction.This is a rapid growing area with numerous contributions from the interdisciplinary areas of nanocatalysis.This paper has summarized the recent progress in the past two years,in synthesizing PtCu-based alloys with various composition and morphologies,and critically discussed the effect of the catalyst preparation method,metal precursor,surfactant,reductant and heating temperature on nanostructure and electronic configuration.The important role of the composition,size,and morphology of PtCu bimetallic catalysts for electro oxidation reactions has been further established for structure-dependency studies.The challenges and perspectives of nanocatalysts for ORR and MOR discussed in this work is to provide further insights into rational design for cost-effective materials for energy.
基金supported by the National Natural Science Foundation(21706290)Natural Science Foundation of Shandong Province(ZR2017MB004,ZR2017BB007)+5 种基金Postdoctoral Research Funding of Shandong Province(201703016)Fundamental Research Funding of Qingdao(17-1-1-67-jch,17-1-1-80-jch)Qingdao Postdoctoral Research Funding(BY20170210)“the Fundamental Research Funds for the Central Universities”(18CX02145A,17CX02017A)new faculty start-up funding from China University of Petroleum(YJ201601058)China Postdoctoral Science Foundation(2017M612374)。
文摘Adipic acid is a dicarboxylic acid of great industrial importance,mainly used in the production of nylon-6,6 and polyurethane.The use of nitric acid as an oxidant in the industrial production of adipic acid poses significant carbon footprint to the environment.Clean adipic acid synthesis methods using a heterogeneous catalyst with H2O2 as oxidant and water as solvent have potential advantages of low catalyst cost,easy synthesis and recovery,cleanness and environmental protection.In this work,hexagonal mesoporous silicate materials were synthesized by a sol–gel method and evaluated for cyclohexanol/cyclohexanone oxidation to adipic acid.The physical and chemical properties of Fe-HMS were characterized by XRD,HR-TEM,BET and UV–Vis.The experimental results showed that Fe-HMS materials show pore sizes ranging from 2–3 nm.W-and Mo-based polyoxometalates were also evaluated and compared to the Fe-based HMS catalysts.To improve the adipic acid yield,the influence of the transition metal as well as the effect of metal loading,reaction temperature and catalyst amount on the catalytic performances of Fe-HMS have been investigated in details.When Si/Fe atomic ratio=100,Fe-HMS catalyst shows the highest activity,with a cyclohexanone conversion of 92.3%and adipic acid selectivity of 29.4%.The reaction pathway of cyclohexanone oxidation was further proposed based on experimental data.
基金Supported by Youth Fund Item of Guizhou Meteorological Bureau(Qianqikehe QN[2012]13)
文摘[ Objective] The research aimed to evaluate vulnerability of the lightning disaster in Guizhou and conduct zoning. [ Method] According to data of the lightning monitoring network and statistical data of the lightning disaster in Guizhou during 2007 -2012, by combining economy and population situations in 9 cities of Guizhou, 6 indicators were used to assess vulnerability of the lightning disasterCG lightning intensity, strong CG lightning intensity, annual average occurrence frequency of the lightning disaster, GDP per capita, population intensity and casualties frequency. By constructing principal component, determining weighing and comprehensive assessment, vulnerability grade of the lightning disaster in Guizhou was divided. [ Result] Guiyang was extremely high vulnerability zone, high vulnerability zone included Zunyi, Bijie and Liupanshui, moderate vulnerabili- ty zone included Anshun, Tongren and Qianxinan, Qiannan was low vulnerability zone, and Qiandongnan was extremely low vulnerability zone. Vulnerability distribution boundary of the lightning disaster in Guizhou was along northeast to southwest, and vulnerability of the lightning disaster gradually weakened from northwest to southeast. [ Conclusion] The research provided scientific basis for preventing lightning disaster and reducing damage of the lightning disaster.
基金supported by the National Natural Science Foundation of China(22078365,22008262)Natural Science Foundation of Shandong Province(ZR2020QB187)+3 种基金Postdoctoral Research Funding of Shandong Province(201703016)Qingdao Postdoctoral Research Funding(BY20170210)the Development Fund of State Key Laboratory of Heavy Oil Processing(20CX02204A)new faculty start-up funding from the China University of Petroleum(YJ201601058)。
文摘Terminal olefins are important building blocks for the industry of biofuels,oligomers,and lubricants production.The industrial processes for production of olefins involving oligomerization of ethylene or cracking of petrochemical waxes have several flaws including low yield and high cost in product separation.Cross-metathesis of bio-derived unsaturated fatty esters and olefins with ethylene(ethenolysis),allows the conversion of sustainable waste biomass to various renewable olefins with much safer,less toxic,sustainable,and zero-CO_(2) emission processes.To our best knowledge,however,a comprehensive summary of key advances in this field(since 2017)is yet to be available,particularly on molecular features of homogeneous and heterogeneous catalysts.This paper presents a critical review on molecular structures of metal complex and oxide catalysts for ethenolysis of olefins and oleochemicals.The influence of cationic centers,coordination conditions,nature of ligands,operating conditions on catalyst performances will be systematically discussed along with relevant reaction mechanism.The key challenges for rational design of coordinated cationic hybrids have been summarized,which will provide insights to technological advancement of large-scale production of oleochemical-derived olefins.
基金supported by the National Natural Science Foundation of China(82171176 and 82001424)the Key Program of the Natural Science Foundation of Zhejiang,China(LZ19H090003)the Health Innovation Talent Program of Zhejiang,China(wscx202306).
文摘Microtubule-associated protein Tau is responsible for the stabilization of neuronal microtubules under normal physiological conditions.Much attention has been focused on Tau’s contribution to cognition,but little research has explored its role in emotions such as pain,anxiety,and depression.In the current study,we found a significant increase in the levels of p-Tau(Thr231),total Tau,IL-1β,and brain-derived neurotrophic factor(BDNF)on day 7 after complete Freund's adjuvant(CFA)injection;they were present in the vast majority of neurons in the spinal dorsal horn.Microinjection of Mapt-shRNA recombinant adeno-associated virus into the spinal dorsal cord alleviated CFA-induced inflammatory pain and inhibited CFA-induced IL-1βand BDNF upregulation.Importantly,Tau overexpression was sufficient to induce hyperalgesia by increasing the expression of IL-1βand BDNF.Furthermore,the activation of glycogen synthase kinase 3 beta partly contributed to Tau accumulation.These findings suggest that Tau in the dorsal horn could be a promising target for chronic inflammatory pain therapy.
基金supported by the National Key R&D Program of China(Grant No.2018YFA0107200)to JWthe National Natural Science Foundation of China(Grant Nos.81830082,82030078,and 81621004 to JL+1 种基金Grant Nos.31771446 and 31970594 to JWGrant No.32100452 to XS).
文摘Serine/arginine-rich splicing factor 7(SRSF7),a known splicing factor,has been revealed to play oncogenic roles in multiple cancers.However,the mechanisms underlying its oncogenic roles have not been well addressed.Here,based on N6-methyladenosine(m^(6)A)co-methylation network analysis across diverse cell lines,we find that the gene expression of SRSF7 is positively correlated with glioblastoma(GBM)cell-specific m^(6)A methylation.We then indicate that SRSF7 is a novel m^(6)A regulator,which specifically facilitates the m^(6)A methylation near its binding sites on the mRNAs involved in cell proliferation and migration,through recruiting the methyltransferase complex.Moreover,SRSF7 promotes the proliferation and migration of GBM cells largely dependent on the presence of the m^(6)A methyltransferase.The two m^(6)A sites on the mRNA for PDZ-binding kinase(PBK)are regulated by SRSF7 and partially mediate the effects of SRSF7 in GBM cells through recognition by insulin-like growth factor 2 mRNA-binding protein 2(IGF2BP2).Together,our discovery reveals a novel role of SRSF7 in regulating m^(6)A and validates the presence and functional importance of temporal-and spatial-specific regulation of m^(6)A mediated by RNA-binding proteins(RBPs).
基金supported by the National Natural Science Foundation of China(82001424,82171176)the Key Program of the Natural Science Foundation of Zhejiang,China(LZ19H090003).
文摘The incidence rate of anxiety and depression is significantly higher in patients with inflammatory bowel diseases(IBD)than in the general population.The mechanisms underlying dextran sulfate sodium(DSS)-induced depressive-like behaviors are still unclear.We clarified that IBD mice induced by repeated administration of DSS presented depressive-like behaviors.The paraventricular thalamic nucleus(PVT)was regarded as the activated brain region by the number of c-fos-labeled neurons.RNA-sequencing analysis showed that lipocalin 2(Lcn2)was upregulated in the PVT of mice with DSS-induced depressive behaviors.Upregulating Lcn2 from neuronal activity induced dendritic spine loss and the secreted protein induced chemokine expression and subsequently contributed to microglial activation leading to blood-brain barrier permeability.Moreover,Lcn2 silencing in the PVT alleviated the DSS-induced depressive-like behaviors.The present study demonstrated that elevated Lcn2 in the PVT is a critical factor for DSS-induced depressive behaviors.