This paper presents an effective and feasible method for detecting dynamic load-altering attacks(D-LAAs)in a smart grid.First,a smart grid discrete system model is established in view of D-LAAs.Second,an adaptive fadi...This paper presents an effective and feasible method for detecting dynamic load-altering attacks(D-LAAs)in a smart grid.First,a smart grid discrete system model is established in view of D-LAAs.Second,an adaptive fading Kalman filter(AFKF)is designed for estimating the state of the smart grid.The AFKF can completely filter out the Gaussian noise of the power system,and obtain a more accurate state change curve(including consideration of the attack).A Euclidean distance ratio detection algorithm based on the AFKF is proposed for detecting D-LAAs.Amplifying imperceptible D-LAAs through the new Euclidean distance ratio improves the D-LAA detection sensitivity,especially for very weak D-LAA attacks.Finally,the feasibility and effectiveness of the Euclidean distance ratio detection algorithm are verified based on simulations.展开更多
Magnetocaloric material is the key working substance for magnetic refrigerant technology,for which the low-field and low-temperature magnetocaloric effect(MCE)performance is of great importance for practical applicati...Magnetocaloric material is the key working substance for magnetic refrigerant technology,for which the low-field and low-temperature magnetocaloric effect(MCE)performance is of great importance for practical applications at low temperatures.Here,a giant low-field magnetocaloric effect in ferromagnetically ordered Er_(1-x)Tm_(x)Al_(2)(0≤x≤1)compounds was reported,and the magnetic structure was characterized based on low-temperature neutron powder diffraction.With increasing Tm content from 0 to 1,the Curie temperature of Er_(1-x)Tm_(x)Al_(2)(0≤x≤1)compounds decreases from 16.0 K to 3.6 K.For Er_(0.7)Tm_(0.3)Al_(2) compound,it showed the largest low-field magnetic entropy change(–SM)with the peak value of 17.2 and 25.7 J/(kg K)for 0–1 T and 0–2 T,respectively.The(–SM)max up to 17.2 J/(kg K)of Er0.7Tm0.3Al2 compound for 0–1 T is the largest among the intermetallic magnetocaloric materials ever reported at temperatures below 20 K.The peak value of adiabatic temperature change(Tad)max was determined as 4.13 K and 6.87 K for 0–1 T and 0–2 T,respectively.The characteristic of second-order magnetic transitions was confirmed on basis of Arrott plots,the quantitative criterion of exponent n,rescaled universal curves,and the mean-field theory criterion.The outstanding low-field MCE performance with low working temperatures indicates that Er_(1-x)Tm_(x)Al_(2)(0≤x≤1)compounds are promising candidates for magnetic cooling materials at liquid hydrogen and liquid helium temperatures.展开更多
Spinal cord injury(SCI) is a devastating traumatic injury that causes persistent, severe motor and sensory dysfunction. Immune responses are involved in functional recovery after SCI. Mucosa-associated lymphoid tissue...Spinal cord injury(SCI) is a devastating traumatic injury that causes persistent, severe motor and sensory dysfunction. Immune responses are involved in functional recovery after SCI. Mucosa-associated lymphoid tissue lymphoma translocation 1(MALT1) has been shown to regulate the survival and differentiation of immune cells and to play a critical role in many diseases, but its function in lesion recovery after SCI remains unclear. In this paper, we generated KI(knock in) mice with a point mutation(C472 G) in the active center of MALT1 and found that the KI mice exhibited improved functional recovery after SCI.Fewer macrophages were recruited to the injury site in KI mice and these macrophages differentiated into anti-inflammatory macrophages. Moreover, macrophages from KI mice exhibited reduced phosphorylation of p65, which in turn resulted in decreased SOCS3 expression and increased pSTAT6 levels.Similar results were obtained upon inhibition of MALT1 paracaspase with the small molecule inhibitor‘‘MI-2' or the more specific inhibitor ‘‘MLT-827'. In patients with SCI, peripheral blood mononuclear cells(PBMC) displayed increased MALT1 paracaspase. Human macrophages showed reduced proinflammatory and increased anti-inflammatory characteristics following the inhibition of MALT1 paracaspase. These findings suggest that inhibition of MALT1 paracaspase activity in the clinic may improve lesion recovery in subjects with SCI.展开更多
基金the Science and Technology Project of the State Grid Shandong Electric Power Company:Research on the vulnerability and prevention of the electrical cyber-physical monitoring system based on interdependent networksthe National Natural Science Foundation of China(61873057)and the Education Department of Jilin Province(JJKH20200118KJ).
文摘This paper presents an effective and feasible method for detecting dynamic load-altering attacks(D-LAAs)in a smart grid.First,a smart grid discrete system model is established in view of D-LAAs.Second,an adaptive fading Kalman filter(AFKF)is designed for estimating the state of the smart grid.The AFKF can completely filter out the Gaussian noise of the power system,and obtain a more accurate state change curve(including consideration of the attack).A Euclidean distance ratio detection algorithm based on the AFKF is proposed for detecting D-LAAs.Amplifying imperceptible D-LAAs through the new Euclidean distance ratio improves the D-LAA detection sensitivity,especially for very weak D-LAA attacks.Finally,the feasibility and effectiveness of the Euclidean distance ratio detection algorithm are verified based on simulations.
基金supported by the National Key Research and Development Program of China(Nos.2021YFB3501202 and 2019YFB2005800)the Science Center of the National Science Foundation of China(No.52088101)+1 种基金the National Natural Science Foundation of China(Nos.51871019,52171170,52130103,51961145305,51971026,and 52171169)the Beijing Natural Science Foundation Key Program(Grant Nos.Z190007 and Z200007),and“111 Project”(No.B170003).
文摘Magnetocaloric material is the key working substance for magnetic refrigerant technology,for which the low-field and low-temperature magnetocaloric effect(MCE)performance is of great importance for practical applications at low temperatures.Here,a giant low-field magnetocaloric effect in ferromagnetically ordered Er_(1-x)Tm_(x)Al_(2)(0≤x≤1)compounds was reported,and the magnetic structure was characterized based on low-temperature neutron powder diffraction.With increasing Tm content from 0 to 1,the Curie temperature of Er_(1-x)Tm_(x)Al_(2)(0≤x≤1)compounds decreases from 16.0 K to 3.6 K.For Er_(0.7)Tm_(0.3)Al_(2) compound,it showed the largest low-field magnetic entropy change(–SM)with the peak value of 17.2 and 25.7 J/(kg K)for 0–1 T and 0–2 T,respectively.The(–SM)max up to 17.2 J/(kg K)of Er0.7Tm0.3Al2 compound for 0–1 T is the largest among the intermetallic magnetocaloric materials ever reported at temperatures below 20 K.The peak value of adiabatic temperature change(Tad)max was determined as 4.13 K and 6.87 K for 0–1 T and 0–2 T,respectively.The characteristic of second-order magnetic transitions was confirmed on basis of Arrott plots,the quantitative criterion of exponent n,rescaled universal curves,and the mean-field theory criterion.The outstanding low-field MCE performance with low working temperatures indicates that Er_(1-x)Tm_(x)Al_(2)(0≤x≤1)compounds are promising candidates for magnetic cooling materials at liquid hydrogen and liquid helium temperatures.
基金supported by the National Key Research and Development Program of China(2021YFB3501202 and 2019YFB2005800)the Science Center of the National Science Foundation of China(52088101)+1 种基金the National Natural Science Foundation of China(51871019,52171170,52130103,51961145305,and 51971026)the 111 Project(B170003)。
基金supported by the National Natural Science Foundation of China (31470872 to YG and 31400770 to ZY)the ‘‘111” project (B16021 to YG and ZY)+5 种基金the Science and Technology Program of Guangzhou (201604020162 to YG)Science & Technology Planning and Key Technology Innovation Projects of Guangdong (201803010001 to ZL)the National Natural Science Foundation of Guangdong (2018A030313576 to GS)Traditional Chinese Medicine Bureau of Guangdong (20181071 to JH)the National Natural Science Foundation of China (31800721 to QW)Medical and Health Development Plan of Shandong Province (2017WS446 to LZ)
文摘Spinal cord injury(SCI) is a devastating traumatic injury that causes persistent, severe motor and sensory dysfunction. Immune responses are involved in functional recovery after SCI. Mucosa-associated lymphoid tissue lymphoma translocation 1(MALT1) has been shown to regulate the survival and differentiation of immune cells and to play a critical role in many diseases, but its function in lesion recovery after SCI remains unclear. In this paper, we generated KI(knock in) mice with a point mutation(C472 G) in the active center of MALT1 and found that the KI mice exhibited improved functional recovery after SCI.Fewer macrophages were recruited to the injury site in KI mice and these macrophages differentiated into anti-inflammatory macrophages. Moreover, macrophages from KI mice exhibited reduced phosphorylation of p65, which in turn resulted in decreased SOCS3 expression and increased pSTAT6 levels.Similar results were obtained upon inhibition of MALT1 paracaspase with the small molecule inhibitor‘‘MI-2' or the more specific inhibitor ‘‘MLT-827'. In patients with SCI, peripheral blood mononuclear cells(PBMC) displayed increased MALT1 paracaspase. Human macrophages showed reduced proinflammatory and increased anti-inflammatory characteristics following the inhibition of MALT1 paracaspase. These findings suggest that inhibition of MALT1 paracaspase activity in the clinic may improve lesion recovery in subjects with SCI.
