An unprecedented chiral secondary amine-catalyzed [3+3] annulation of isatin N,N’-cyclic azomethine imines with α,β-unsaturated aldehydes was developed.This strategy allowed the construction of structurally novel s...An unprecedented chiral secondary amine-catalyzed [3+3] annulation of isatin N,N’-cyclic azomethine imines with α,β-unsaturated aldehydes was developed.This strategy allowed the construction of structurally novel spiro N-heterocyclic oxindole derivatives in good yields(up to 91%) and good to excellent enantioselectivities(up to>99% ee),albeit with modest diastereoselectivities(up to 3.1:1 dr).展开更多
基金supported by the National Natural Science Foundation of China (No.21572053)Opening Project of Zhejiang Provincial Preponderant and Characteristic Subject of Key University (Traditional Chinese Pharmacology),Zhejiang Chinese Medical University (No.ZYAOX2018029)。
文摘An unprecedented chiral secondary amine-catalyzed [3+3] annulation of isatin N,N’-cyclic azomethine imines with α,β-unsaturated aldehydes was developed.This strategy allowed the construction of structurally novel spiro N-heterocyclic oxindole derivatives in good yields(up to 91%) and good to excellent enantioselectivities(up to>99% ee),albeit with modest diastereoselectivities(up to 3.1:1 dr).
