Asphalt pavement is currently one of the main components in the construction of roads and bridges.However,from a practical point of view,various quality problems are prone to occur in the surface layer of asphalt pave...Asphalt pavement is currently one of the main components in the construction of roads and bridges.However,from a practical point of view,various quality problems are prone to occur in the surface layer of asphalt pavement,which will lead to the poor overall quality of road and bridge projects.Therefore,it should be applied reasonably.Advanced testing technologies are used to test the mixture quality,compaction,segregation,thickness,and other aspects of the asphalt pavement surface layer,so as to improve the quality of the asphalt pavement surface layer,and then improve the overall quality of road and bridge construction.Therefore,this paper mainly analyzes the technologies for asphalt pavement surface layer testing in road and bridge engineering construction.展开更多
In order to promote the development of road traffic in our country,it is necessary to strengthen the research on municipal road construction technology,constantly innovate construction technology and construction tech...In order to promote the development of road traffic in our country,it is necessary to strengthen the research on municipal road construction technology,constantly innovate construction technology and construction technique,and then effectively ensure the rapid development of urban traffic.This paper mainly elaborates on asphalt road surface regeneration technology,modified asphalt concrete,concrete road surface anti-cracking technology,three-dimensional printing technology,composite material road surface,polymer composite materials,etc.,to ensure the development of urban transportation and the quality of municipal road projects.展开更多
With the continuous development of China,the requirements for road construction are also increasing.Among them,strengthening the performance of roadbed test can effectively improve road construction.Besides,it is also...With the continuous development of China,the requirements for road construction are also increasing.Among them,strengthening the performance of roadbed test can effectively improve road construction.Besides,it is also crucial to perform suitable tests in a timely manner.Therefore,highway inspection technology should be improved for the continuous development of highway construction,which will be explained in this paper,in hopes of improving the construction of highway in China.展开更多
The incidence rate of colon cancer ranks the third among malignant tumors worldwide.Gloeostereum incarnatum(GI),a fungus with homology of medicine and food,has multiple pharmacological activities.It was investigated i...The incidence rate of colon cancer ranks the third among malignant tumors worldwide.Gloeostereum incarnatum(GI),a fungus with homology of medicine and food,has multiple pharmacological activities.It was investigated in this study that the anti-colon cancer effect of polysaccharides purifi ed from GI(GIPS)in ApcMinC/Gpt mice(an in situ colon cancer mouse model).Eight-week administration with GIPS at doses of 30 or 90 mg/kg strongly inhibited tumor growth including the reduction on numbers and the suppression of the size without infl uencing the animals’body weight and organ functions.According to the proteomics performing by antibody array,among 308 detected cytokines,GIPS significantly regulated 89 of them.Compared with vehicle-treated mice,GIPS effectively reduced the levels of interleukin(IL)-1β,IL-4,IL-6,IL-17,IL-22,tumor necrosis factor(TNF)-α,matrix metalloproteinase(MMP)-2,and enhanced the levels of IL-15 and IL-18 in serum and/or colon tissues,which suggested its anti-inflammation of GIPS.GIPS suppressed nuclear aggregation of β-catenin,affected the expression of WNT1 and related proteins,thereby regulated the activation of the Wnt signaling.Altogether,GIPS can inhibit the growth of colon cancer,at least partially,via inhibiting the Wnt/β-catenin signaling pathway.展开更多
Three types of rainfall(storm,moderate and slight rainfall) in the Beijing area were simulated by the Weather Research and Forecast(WRF3.2) model coupled with Milbrandt-two-moment cloud microphysics scheme,to explore ...Three types of rainfall(storm,moderate and slight rainfall) in the Beijing area were simulated by the Weather Research and Forecast(WRF3.2) model coupled with Milbrandt-two-moment cloud microphysics scheme,to explore the effect of aerosols on clouds and precipitation under continental and maritime aerosol scenarios.Results indicate that an increase of aerosols has various effects on clouds and precipitation.(1) The amount of surface precipitation is obviously affected.With an increase of aerosol concentration,the 48-hr total precipitation of storm and moderate rainfall decreased by 23% and 16.6%,respectively,and the 24-hr total precipitation of slight rainfall decreased by 14.0%.(2) The distribution of surface precipitation is also clearly affected.The average precipitation for a rain storm increases in most parts of western Beijing and decreases by more than 20 mm in most parts of eastern Beijing with increasing aerosol concentration.The average precipitation of moderate rainfall decreases by 0.1-5 mm in most parts of the Beijing area.The effect of increased aerosol concentration is weak for slight rainfall distribution in the study area.(3) With an increase of aerosol concentration,a narrower width and lower precipitation peak value are found in the storm rainfall,and its duration is prolonged for the high aerosol concentration.An earlier precipitation termination of moderate rainfall is found with increasing aerosol concentration.(4) The upper-air hydrometeors vary with aerosol concentration.For storm and moderate rainfall,significantly higher cloud water concentration and lower rain water were found under the continental aerosol scenario.展开更多
In international trade, one of the major things is how to protect benefits and implement obligations of seller and buyer, more concerns are than domestic businesses. As a result, solutions for facilitate and ensure ob...In international trade, one of the major things is how to protect benefits and implement obligations of seller and buyer, more concerns are than domestic businesses. As a result, solutions for facilitate and ensure obligations are undeniable necessity. By the nature, Letter of credit balance risk for both seller and buyer sides, protect the benefits and ensure obligations. Letter of credit plays a very important role in international trade.展开更多
Dear Editor,Middle East respiratory syndrome-related coronavirus(MERS-CoV)is the pathogen responsible for the outbreak of MERS,and we are currently being affected by coronavirus disease 2019(COVID-19)due to infection ...Dear Editor,Middle East respiratory syndrome-related coronavirus(MERS-CoV)is the pathogen responsible for the outbreak of MERS,and we are currently being affected by coronavirus disease 2019(COVID-19)due to infection by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The S protein of SARS-CoV-2 or MERS-CoV binds angiotensin-converting enzyme 2(ACE2)or dipeptidyl peptidase-4(DPP4),respectively,to facilitate viral particles entry into cells1.The COVID-19 pandemic has caused major socioeconomic disruptions globally.展开更多
The interaction among type Ⅱ collagen(CⅡ),human DR4 major histocompatibility complex type Ⅱ molecule(MHC Ⅱ)and T-cell receptor(TCR)is associated with the development of rheumatoid arthritis(RA).The activation of T...The interaction among type Ⅱ collagen(CⅡ),human DR4 major histocompatibility complex type Ⅱ molecule(MHC Ⅱ)and T-cell receptor(TCR)is associated with the development of rheumatoid arthritis(RA).The activation of T cells can be reduced through exposure to modified CⅡ(263-272)glycopeptide fragment via competitive inhibition with self-antigen.In this work,30 peptides based on the sequence of CⅡ(263-272)were prepared and evaluated for their binding to DR4 protein by surface plasmon resonance(SPR)assay.The effect on the secretion of pro-inflammatory factors by the spleen cells in collagen induced rheumatoid arthritis(CIA)mouse was also investigated.Two N-glycosylated CⅡ peptides were identified to have strong binding to the human recombinant DR4 protein and weak proinflammatory effect.These glycopeptides could be developed as therapeutic saccharide vaccines for the treatment of rheumatoid arthritis(RA).展开更多
文摘Asphalt pavement is currently one of the main components in the construction of roads and bridges.However,from a practical point of view,various quality problems are prone to occur in the surface layer of asphalt pavement,which will lead to the poor overall quality of road and bridge projects.Therefore,it should be applied reasonably.Advanced testing technologies are used to test the mixture quality,compaction,segregation,thickness,and other aspects of the asphalt pavement surface layer,so as to improve the quality of the asphalt pavement surface layer,and then improve the overall quality of road and bridge construction.Therefore,this paper mainly analyzes the technologies for asphalt pavement surface layer testing in road and bridge engineering construction.
文摘In order to promote the development of road traffic in our country,it is necessary to strengthen the research on municipal road construction technology,constantly innovate construction technology and construction technique,and then effectively ensure the rapid development of urban traffic.This paper mainly elaborates on asphalt road surface regeneration technology,modified asphalt concrete,concrete road surface anti-cracking technology,three-dimensional printing technology,composite material road surface,polymer composite materials,etc.,to ensure the development of urban transportation and the quality of municipal road projects.
文摘With the continuous development of China,the requirements for road construction are also increasing.Among them,strengthening the performance of roadbed test can effectively improve road construction.Besides,it is also crucial to perform suitable tests in a timely manner.Therefore,highway inspection technology should be improved for the continuous development of highway construction,which will be explained in this paper,in hopes of improving the construction of highway in China.
基金This work was supported by the Ministry of Science and Technology of the People’s Republic of China(Grant No.2018YFE0107800)the“13th Five-year”Science and Technology Projects from Education Department in Jilin Province of P.R.China(Grant No.JJKH20190108KJ)Industrial Technology Research and Development Projects from Development and Reform Commission of Jilin Province(Grant No.2019C050-8).
文摘The incidence rate of colon cancer ranks the third among malignant tumors worldwide.Gloeostereum incarnatum(GI),a fungus with homology of medicine and food,has multiple pharmacological activities.It was investigated in this study that the anti-colon cancer effect of polysaccharides purifi ed from GI(GIPS)in ApcMinC/Gpt mice(an in situ colon cancer mouse model).Eight-week administration with GIPS at doses of 30 or 90 mg/kg strongly inhibited tumor growth including the reduction on numbers and the suppression of the size without infl uencing the animals’body weight and organ functions.According to the proteomics performing by antibody array,among 308 detected cytokines,GIPS significantly regulated 89 of them.Compared with vehicle-treated mice,GIPS effectively reduced the levels of interleukin(IL)-1β,IL-4,IL-6,IL-17,IL-22,tumor necrosis factor(TNF)-α,matrix metalloproteinase(MMP)-2,and enhanced the levels of IL-15 and IL-18 in serum and/or colon tissues,which suggested its anti-inflammation of GIPS.GIPS suppressed nuclear aggregation of β-catenin,affected the expression of WNT1 and related proteins,thereby regulated the activation of the Wnt signaling.Altogether,GIPS can inhibit the growth of colon cancer,at least partially,via inhibiting the Wnt/β-catenin signaling pathway.
基金supported by the CAS Strategic Priority Research Program (XDA05110101)Basic Research Development Program of China (2011CB403406)+1 种基金National Special Fund for Public Welfare Industry (Meteorology) (GYHY200706036)Natural Science Basic Research Plan in Shaanxi Province of China (No. 2010JM5002)
文摘Three types of rainfall(storm,moderate and slight rainfall) in the Beijing area were simulated by the Weather Research and Forecast(WRF3.2) model coupled with Milbrandt-two-moment cloud microphysics scheme,to explore the effect of aerosols on clouds and precipitation under continental and maritime aerosol scenarios.Results indicate that an increase of aerosols has various effects on clouds and precipitation.(1) The amount of surface precipitation is obviously affected.With an increase of aerosol concentration,the 48-hr total precipitation of storm and moderate rainfall decreased by 23% and 16.6%,respectively,and the 24-hr total precipitation of slight rainfall decreased by 14.0%.(2) The distribution of surface precipitation is also clearly affected.The average precipitation for a rain storm increases in most parts of western Beijing and decreases by more than 20 mm in most parts of eastern Beijing with increasing aerosol concentration.The average precipitation of moderate rainfall decreases by 0.1-5 mm in most parts of the Beijing area.The effect of increased aerosol concentration is weak for slight rainfall distribution in the study area.(3) With an increase of aerosol concentration,a narrower width and lower precipitation peak value are found in the storm rainfall,and its duration is prolonged for the high aerosol concentration.An earlier precipitation termination of moderate rainfall is found with increasing aerosol concentration.(4) The upper-air hydrometeors vary with aerosol concentration.For storm and moderate rainfall,significantly higher cloud water concentration and lower rain water were found under the continental aerosol scenario.
文摘In international trade, one of the major things is how to protect benefits and implement obligations of seller and buyer, more concerns are than domestic businesses. As a result, solutions for facilitate and ensure obligations are undeniable necessity. By the nature, Letter of credit balance risk for both seller and buyer sides, protect the benefits and ensure obligations. Letter of credit plays a very important role in international trade.
基金This work was supported by Hong Kong Research Grant Council(RGC)grants(11101717 and 11103620),NSFC(21778045 and 32070702)Shenzhen government research grant(JSGG20200225150702770).
文摘Dear Editor,Middle East respiratory syndrome-related coronavirus(MERS-CoV)is the pathogen responsible for the outbreak of MERS,and we are currently being affected by coronavirus disease 2019(COVID-19)due to infection by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The S protein of SARS-CoV-2 or MERS-CoV binds angiotensin-converting enzyme 2(ACE2)or dipeptidyl peptidase-4(DPP4),respectively,to facilitate viral particles entry into cells1.The COVID-19 pandemic has caused major socioeconomic disruptions globally.
基金Supported by Scientific Research Project of the Administration of Traditional Chinese Medicine of Hebei Province:2014003,2016004Planned Project of Hebei Provincial Science and Technology Department:16277725DResearch Project of Humanistic and Social Science of Universities and Colleges in Hebei Province:BJ2016086~~
基金supported by the National Natural Science Foundation of China(Nos.81930097,21977005,82151223)supported by the National Key R&D Program of China(No.2022YFF1203005).
文摘The interaction among type Ⅱ collagen(CⅡ),human DR4 major histocompatibility complex type Ⅱ molecule(MHC Ⅱ)and T-cell receptor(TCR)is associated with the development of rheumatoid arthritis(RA).The activation of T cells can be reduced through exposure to modified CⅡ(263-272)glycopeptide fragment via competitive inhibition with self-antigen.In this work,30 peptides based on the sequence of CⅡ(263-272)were prepared and evaluated for their binding to DR4 protein by surface plasmon resonance(SPR)assay.The effect on the secretion of pro-inflammatory factors by the spleen cells in collagen induced rheumatoid arthritis(CIA)mouse was also investigated.Two N-glycosylated CⅡ peptides were identified to have strong binding to the human recombinant DR4 protein and weak proinflammatory effect.These glycopeptides could be developed as therapeutic saccharide vaccines for the treatment of rheumatoid arthritis(RA).
