In this paper,we consider the fully parabolic Chemotaxis system with the general logistic source{ut=Δ(γ(v)u)+λu-μu^(k),x∈Ω,t>0,vt=△v+wz,x∈Ω,t>0,wt=-wz,x∈Ω,t>0,zt=△z-z+u,x∈Ω,t>0 whereΩ⊂ℝn(n≥...In this paper,we consider the fully parabolic Chemotaxis system with the general logistic source{ut=Δ(γ(v)u)+λu-μu^(k),x∈Ω,t>0,vt=△v+wz,x∈Ω,t>0,wt=-wz,x∈Ω,t>0,zt=△z-z+u,x∈Ω,t>0 whereΩ⊂ℝn(n≥1)is a smooth and bounded domain,λ≥0,μ≥0,κ>1,and the motility function satisfies thatγ(v)∈C3([0,∞)),γ(v)>0,γ′(v)≤0 for all v≥0.Considering the Neumann boundary condition,we obtain the global boundedness of solutions if one of the following conditions holds:(i)λ=μ=0,1≤nλ3;(ii)λ>0,μ>0,combined withκ>1,1≤n≤3 or k>n+2/4,,n>3.Moreover,we prove that the solution (u, v, w, z) exponentially converges to the constant steady state ((λ/μ)1/k-1,∫Ωv0dx+∫Ωw0dx/|Ω|,0,(λ/μ)1/k-1).展开更多
This work explores the predator-prey chemotaxis system with two chemicals {u_(t) = Δu + ∇ ・ (u∇v) + μ_(1)u(1 − u − α_(1)w), x ∈ Ω, t > 0,v_(t )= Δv −α_(1)v + β_(1)w, x ∈ Ω, t > 0,w_(t) = Δw − ξ∇ ・ (w...This work explores the predator-prey chemotaxis system with two chemicals {u_(t) = Δu + ∇ ・ (u∇v) + μ_(1)u(1 − u − α_(1)w), x ∈ Ω, t > 0,v_(t )= Δv −α_(1)v + β_(1)w, x ∈ Ω, t > 0,w_(t) = Δw − ξ∇ ・ (w∇z) + μ_(2)w(1 + α_(2)u − w), x ∈ Ω, t > 0,z_(t) =Δz −α_(2)z +β_(2)u, x ∈ Ω, t > 0, in an arbitrary smooth bounded domainΩ■R^(n) under homogeneous Neumann boundary conditions.The parameters in the system are positive.We first prove that if n≤3,the corresponding initial-boundary value problem admits a unique global bounded classical solution,under the assumption thatχ,ξ,μ_(i),a_(i),α_(i) andβ_(i)(i=1,2)satisfy some suitable conditions.Subsequently,we also analyse the asymptotic behavior of solutions to the above system and show that·when a_(1)<1 and bothμ1/χ^(2) andμ2/ξ^(2) are sufficiently large,the global solution(u,v,w,z)of this system exponentially converges to(1-a_(1)/1+a_(1)a_(2),β_(1)(1+a_(2))/α_(1)(1+a_(1)a_(2)),1+a_(2)/1+a_(1)a_(2),β_(2)(1-a_(1))/α_(2)(1+a_(1)a_(2)))as t→∞;·when a1>1 andμ_(2)/ξ_(2) is sufficiently large,the global bounded classical solution(u,v,w,z)of this system exponentially converges to(0,α_(1)/β_(1),1,0)as t→∞;·when a1=1 andμ_(2)/ξ_(2) is sufficiently large,the global bounded classical solution(u,v,w,z)of this system polynomially converges to(0,α_(1)/β_(1),1,0)as t→∞.展开更多
In this article,we consider the Lipschitz metric of conservative weak solutions for the rotation-Camassa-Holm equation.Based on defining a Finsler-type norm on the tangent space for solutions,we first establish the Li...In this article,we consider the Lipschitz metric of conservative weak solutions for the rotation-Camassa-Holm equation.Based on defining a Finsler-type norm on the tangent space for solutions,we first establish the Lipschitz metric for smooth solutions,then by proving the generic regularity result,we extend this metric to general weak solutions.展开更多
Human adenoviruses(HAdVs)can cause acute hepatitis in immunocompromised patients.However,it is unclear whether HAdVs are contributors to hepatitis in immunocompetent children.In this study,the liver function test(LFT)...Human adenoviruses(HAdVs)can cause acute hepatitis in immunocompromised patients.However,it is unclear whether HAdVs are contributors to hepatitis in immunocompetent children.In this study,the liver function test(LFT)results were retrospectively analyzed among children hospitalized(age<14 years)between January 2016 and October 2019 for acute respiratory infection caused by adenoviruses.Alanine transaminase(ALT)and aspartate aminotransferase(AST)levels were elevated in 7.74%and 46.89%of patients,respectively.All patients with>2 folds of the upper limit of ALT or AST levels were infected with HAdV-7 or HAdV-55.Significantly higher levels of ALT,AST,γ-glutamyl transpeptidase(γ-GT),and lower albumin levels were observed in the HAdV-7 infection group than in the HAdV-3 infection group.HAdV-55 infection led to significantly higherγ-GT,total bilirubin,and direct bilirubin levels than the other infection types.The records of four patients with serial monitoring of the LFT results were further analyzed.Multiple indicators remained abnormal during the entire hospitalization in these patients.These results indicate that HAdV infection is often accompanied by abnormal liver function,and HAdV-7 and HAdV-55 might be under-recognized contributors to hepatitis among children.展开更多
During 2018–2019,a severe human adenovirus(HAdV)infection outbreak occurred in southern China.Here,we screened 18 respiratory pathogens in 1704 children(≤14 years old)hospitalized with acute respiratory illness in G...During 2018–2019,a severe human adenovirus(HAdV)infection outbreak occurred in southern China.Here,we screened 18 respiratory pathogens in 1704 children(≤14 years old)hospitalized with acute respiratory illness in Guangzhou,China,in 2019.In total,151 patients had positive HAdV test results;34.4%(52/151)of them exhibited severe illness.HAdV infection occurred throughout the year,with a peak in summer.The median patient age was 3.0(interquartile range:1.1–5.0)years.Patients with severe HAdV infection exhibited increases in12 clinical indexes(P≤0.019)and decreases in four indexes(P≤0.007),compared with patients exhibiting nonsevere infection.No significant differences were found in age or sex distribution according to HAdV infection severity(P>0.05);however,the distributions of comorbid disease and HAdV co-infection differed according to HAdV infection severity(P<0.05).The main epidemic types were HAdV-3(47.0%,71/151)and HAdV-7(46.4%,70/151).However,the severe illness rate was significantly higher in patients with HAdV-7(51.4%)than in patients with HAdV-3(19.7%)and other types of HAdV(20%)(P<0.001).Sequencing analysis of genomes/capsid genes of 13 HAdV-7 isolates revealed high similarity to previous Chinese isolates.A representative HAdV-7isolate exhibited a similar proliferation curve to the curve described for the epidemic HAdV-3 strain Guangzhou01(accession no.DQ099432)(P>0.05);the HAdV-7 isolate exhibited stronger virulence and infectivity,compared with HAdV-3(P<0.001).Overall,comorbid disease,HAdV co-infection,and high virulence and infectivity of HAdV-7 were critical risk factors for severe HAdV infection;these data can facilitate treatment,control,and prevention of HAdV infection.展开更多
基金supported by the NSFC(12301260)the Hong Kong Scholars Program(XJ2023002,2023-078)+14 种基金the Double First-Class Construction-Talent Introduction of Southwest University(SWU-KR22037)the Chongqing Post-Doctoral Fund for Staying in Chongqing(2022)partially supported by the NSFC(12271064,11971082)the Chongqing Talent Support Program(cstc2022ycjh-bgzxm0169)the Natural Science Foundation of Chongqing(cstc2021jcyj-msxmX1051)the Fundamental Research Funds for the Central Universities(2020CDJQY-Z001,2019CDJCYJ001)the Key Laboratory of Nonlinear Analysis and its Applications(Chongqing University)Ministry of EducationChongqing Key Laboratory of Analytic Mathematics and Applicationssupported by the NSFC(12301261)the Scientific Research Starting Project of SWPU(2021QHZ016)the Sichuan Science and Technology Program(2023NSFSC1365)the Nanchong Municipal Government-Universities Scientific Cooperation Project(SXHZ045)supported by the China Scholarship Council(202206050060)the Graduate Research and Innovation Foundation of Chongqing(CYB22044)。
文摘In this paper,we consider the fully parabolic Chemotaxis system with the general logistic source{ut=Δ(γ(v)u)+λu-μu^(k),x∈Ω,t>0,vt=△v+wz,x∈Ω,t>0,wt=-wz,x∈Ω,t>0,zt=△z-z+u,x∈Ω,t>0 whereΩ⊂ℝn(n≥1)is a smooth and bounded domain,λ≥0,μ≥0,κ>1,and the motility function satisfies thatγ(v)∈C3([0,∞)),γ(v)>0,γ′(v)≤0 for all v≥0.Considering the Neumann boundary condition,we obtain the global boundedness of solutions if one of the following conditions holds:(i)λ=μ=0,1≤nλ3;(ii)λ>0,μ>0,combined withκ>1,1≤n≤3 or k>n+2/4,,n>3.Moreover,we prove that the solution (u, v, w, z) exponentially converges to the constant steady state ((λ/μ)1/k-1,∫Ωv0dx+∫Ωw0dx/|Ω|,0,(λ/μ)1/k-1).
基金supported by the Young Scholars Development Fund of SWPU(202199010087)the Scientific Research Starting Project of SWPU(2021QHZ016)+2 种基金supported by the National Natural Science Foundation of China(11771062and 11971082)the Fundamental Research Funds for the Central Universities(2019CDJCYJ001)Chongqing Key Laboratory of Analytic Mathematics and Applications。
文摘This work explores the predator-prey chemotaxis system with two chemicals {u_(t) = Δu + ∇ ・ (u∇v) + μ_(1)u(1 − u − α_(1)w), x ∈ Ω, t > 0,v_(t )= Δv −α_(1)v + β_(1)w, x ∈ Ω, t > 0,w_(t) = Δw − ξ∇ ・ (w∇z) + μ_(2)w(1 + α_(2)u − w), x ∈ Ω, t > 0,z_(t) =Δz −α_(2)z +β_(2)u, x ∈ Ω, t > 0, in an arbitrary smooth bounded domainΩ■R^(n) under homogeneous Neumann boundary conditions.The parameters in the system are positive.We first prove that if n≤3,the corresponding initial-boundary value problem admits a unique global bounded classical solution,under the assumption thatχ,ξ,μ_(i),a_(i),α_(i) andβ_(i)(i=1,2)satisfy some suitable conditions.Subsequently,we also analyse the asymptotic behavior of solutions to the above system and show that·when a_(1)<1 and bothμ1/χ^(2) andμ2/ξ^(2) are sufficiently large,the global solution(u,v,w,z)of this system exponentially converges to(1-a_(1)/1+a_(1)a_(2),β_(1)(1+a_(2))/α_(1)(1+a_(1)a_(2)),1+a_(2)/1+a_(1)a_(2),β_(2)(1-a_(1))/α_(2)(1+a_(1)a_(2)))as t→∞;·when a1>1 andμ_(2)/ξ_(2) is sufficiently large,the global bounded classical solution(u,v,w,z)of this system exponentially converges to(0,α_(1)/β_(1),1,0)as t→∞;·when a1=1 andμ_(2)/ξ_(2) is sufficiently large,the global bounded classical solution(u,v,w,z)of this system polynomially converges to(0,α_(1)/β_(1),1,0)as t→∞.
基金supported by Chongqing Post-doctoral Innovative Talent Support Progran,the Fundamental Research Funds for the Central Universities(XDJK2020C054)China Postdoctoral Science Foundation(2020M673102)+3 种基金the Natural Science Foundation of Chongqing,China,(cstc2020jcyj-bsh X0071)supported by the Fundamental Research Funds for the Central Universities(2019CDJCYJ001,2020CQJQ-Z001)the NSFC(11771062 and 11971082)Chongqing Key Laboratory of Analytic Mathematics and Applications。
文摘In this article,we consider the Lipschitz metric of conservative weak solutions for the rotation-Camassa-Holm equation.Based on defining a Finsler-type norm on the tangent space for solutions,we first establish the Lipschitz metric for smooth solutions,then by proving the generic regularity result,we extend this metric to general weak solutions.
基金This study was supported by the National Natural Science Foundation of China(82072264,81970003)Natural Science Foundation of Guangdong Province,China(2021A1515011071)The study sponsors had no involvement in the study design,in the collection,analysis and interpretation of data,in the writing of the manuscript,and in the decision to submit the manuscript for publication.
文摘Human adenoviruses(HAdVs)can cause acute hepatitis in immunocompromised patients.However,it is unclear whether HAdVs are contributors to hepatitis in immunocompetent children.In this study,the liver function test(LFT)results were retrospectively analyzed among children hospitalized(age<14 years)between January 2016 and October 2019 for acute respiratory infection caused by adenoviruses.Alanine transaminase(ALT)and aspartate aminotransferase(AST)levels were elevated in 7.74%and 46.89%of patients,respectively.All patients with>2 folds of the upper limit of ALT or AST levels were infected with HAdV-7 or HAdV-55.Significantly higher levels of ALT,AST,γ-glutamyl transpeptidase(γ-GT),and lower albumin levels were observed in the HAdV-7 infection group than in the HAdV-3 infection group.HAdV-55 infection led to significantly higherγ-GT,total bilirubin,and direct bilirubin levels than the other infection types.The records of four patients with serial monitoring of the LFT results were further analyzed.Multiple indicators remained abnormal during the entire hospitalization in these patients.These results indicate that HAdV infection is often accompanied by abnormal liver function,and HAdV-7 and HAdV-55 might be under-recognized contributors to hepatitis among children.
基金supported by the Guangzhou Science and Technology Program-Zhongnanshan Medical Foundation of Guangdong Province(202102010359-ZNSA-2020003)the Emergency Key Program of Guangzhou Laboratory(EKPG21-13)+3 种基金the National Natural Science Foundation of China(81970003,31900877)the Natural Science Foundation of Guangdong Province of China(2018A030310401)Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease(GHMJLRID-Z-202109)the Special Project for COVID-19 Prevention and Control of Zhongnanshan Medical Foundation of Guangdong Province(ZNSA-2020012)。
文摘During 2018–2019,a severe human adenovirus(HAdV)infection outbreak occurred in southern China.Here,we screened 18 respiratory pathogens in 1704 children(≤14 years old)hospitalized with acute respiratory illness in Guangzhou,China,in 2019.In total,151 patients had positive HAdV test results;34.4%(52/151)of them exhibited severe illness.HAdV infection occurred throughout the year,with a peak in summer.The median patient age was 3.0(interquartile range:1.1–5.0)years.Patients with severe HAdV infection exhibited increases in12 clinical indexes(P≤0.019)and decreases in four indexes(P≤0.007),compared with patients exhibiting nonsevere infection.No significant differences were found in age or sex distribution according to HAdV infection severity(P>0.05);however,the distributions of comorbid disease and HAdV co-infection differed according to HAdV infection severity(P<0.05).The main epidemic types were HAdV-3(47.0%,71/151)and HAdV-7(46.4%,70/151).However,the severe illness rate was significantly higher in patients with HAdV-7(51.4%)than in patients with HAdV-3(19.7%)and other types of HAdV(20%)(P<0.001).Sequencing analysis of genomes/capsid genes of 13 HAdV-7 isolates revealed high similarity to previous Chinese isolates.A representative HAdV-7isolate exhibited a similar proliferation curve to the curve described for the epidemic HAdV-3 strain Guangzhou01(accession no.DQ099432)(P>0.05);the HAdV-7 isolate exhibited stronger virulence and infectivity,compared with HAdV-3(P<0.001).Overall,comorbid disease,HAdV co-infection,and high virulence and infectivity of HAdV-7 were critical risk factors for severe HAdV infection;these data can facilitate treatment,control,and prevention of HAdV infection.