As a product in the process of insulin synthesis, C-peptide’s physiological function is still not very clear. Recent studies have shown that C-peptide has many potential cell targets and has biological effects on a v...As a product in the process of insulin synthesis, C-peptide’s physiological function is still not very clear. Recent studies have shown that C-peptide has many potential cell targets and has biological effects on a variety of tissue systems in humans and other animals. In this paper, the effects of C-peptide on diabetic complications, reproductive endocrine system, blood system, tissue repair, and neoplastic diseases were reviewed to provide references for further clarification of c-peptide related problems.展开更多
To the Editor:Lung cancer,one of the most common types of tumor,is also the leading cause of cancer death,accounting for an estimated 1.8 million deaths worldwide.Early recognition of lung cancer is critical.It has be...To the Editor:Lung cancer,one of the most common types of tumor,is also the leading cause of cancer death,accounting for an estimated 1.8 million deaths worldwide.Early recognition of lung cancer is critical.It has been established that nitric oxide and its byproducts play a role in pathophysiological processes of lung cancer,such as tumor immunity,inflammation,and lung tumor progression.[1]Exhaled nitric oxide(eNO)concentrations can be measured by non-invasive devices.The alveolar concentration of nitric oxide(CaNO)has been proposed as a marker of distal airway inflammation,but its value in nonsmall cell lung cancer(NSCLC)is unknown.展开更多
Atomistic mechanisms of frictional energy dissipation have attracted significant attention.However,the dynamics of phonon excitation and dissipation remain elusive for many friction processes.Through systematic fast F...Atomistic mechanisms of frictional energy dissipation have attracted significant attention.However,the dynamics of phonon excitation and dissipation remain elusive for many friction processes.Through systematic fast Fourier transform(FFT)analyses of the frictional signals as a silicon tip sliding over a graphite surface at different angles and velocities,we experimentally demonstrate that friction mainly excites non-equilibrium phonons at the washboard frequency and its harmonics.Using molecular dynamics(MD)simulations,we further disclose the phononic origin of structural lubrication,i.e.,the drastic reduction of friction force as the contact angle between two commensurate surfaces changes.In commensurate contacting states,friction excites a large amount of phonons at the washboard frequency and many orders of its harmonics that perfectly match each other in the sliding tip and substrate,while for incommensurate cases,only limited phonons are generated at mismatched washboard frequencies and few low order harmonics in the tip and substrate.展开更多
文摘As a product in the process of insulin synthesis, C-peptide’s physiological function is still not very clear. Recent studies have shown that C-peptide has many potential cell targets and has biological effects on a variety of tissue systems in humans and other animals. In this paper, the effects of C-peptide on diabetic complications, reproductive endocrine system, blood system, tissue repair, and neoplastic diseases were reviewed to provide references for further clarification of c-peptide related problems.
基金National Natural Science Foundation of China(Nos.82170032 and 81970032)
文摘To the Editor:Lung cancer,one of the most common types of tumor,is also the leading cause of cancer death,accounting for an estimated 1.8 million deaths worldwide.Early recognition of lung cancer is critical.It has been established that nitric oxide and its byproducts play a role in pathophysiological processes of lung cancer,such as tumor immunity,inflammation,and lung tumor progression.[1]Exhaled nitric oxide(eNO)concentrations can be measured by non-invasive devices.The alveolar concentration of nitric oxide(CaNO)has been proposed as a marker of distal airway inflammation,but its value in nonsmall cell lung cancer(NSCLC)is unknown.
基金National Natural Science Foundation of China(Grant Nos.52035003,52065037,51575104,and 52175161)the China Postdoctoral Science Foundation(Grant No.2021MD703810)+1 种基金the Postdoctoral Science Foundation of Gansu Academy of Sciences(Grant No.BSH202101)the Southeast University“Zhongying Young Scholars”Project for financial support.
文摘Atomistic mechanisms of frictional energy dissipation have attracted significant attention.However,the dynamics of phonon excitation and dissipation remain elusive for many friction processes.Through systematic fast Fourier transform(FFT)analyses of the frictional signals as a silicon tip sliding over a graphite surface at different angles and velocities,we experimentally demonstrate that friction mainly excites non-equilibrium phonons at the washboard frequency and its harmonics.Using molecular dynamics(MD)simulations,we further disclose the phononic origin of structural lubrication,i.e.,the drastic reduction of friction force as the contact angle between two commensurate surfaces changes.In commensurate contacting states,friction excites a large amount of phonons at the washboard frequency and many orders of its harmonics that perfectly match each other in the sliding tip and substrate,while for incommensurate cases,only limited phonons are generated at mismatched washboard frequencies and few low order harmonics in the tip and substrate.
