Dear Editor,Angiosarcoma is a rare malignancy,which accounts for approximately 1%-2%of soft-tissue sarcomas[1].It can occur at any site within the human body.Some research-ers suggested that site distribution may be d...Dear Editor,Angiosarcoma is a rare malignancy,which accounts for approximately 1%-2%of soft-tissue sarcomas[1].It can occur at any site within the human body.Some research-ers suggested that site distribution may be different between Eastern Asian and Western countries[1].Sev-eral factors,such as age,stage at diagnosis,performance status,site of the disease,histological grade,tumor size,and visceral involvement,were suggested as prognos-tic factors in angiosarcoma[2-5].However,there is still controversy regarding to which prognostic factors are significantly important.As there are no randomized clinical trials for angiosarcoma,its treatments are guided based on guidelines of soft-tissue sarcoma or the results of several retrospective studies.Radical surgery is the preferred treatment for angiosarcoma[2-4].Some stud-ies suggested that receiving adjuvant chemotherapy(CT)is associated with better outcome[5],while other studies have shown that adjuvant CT has no significant effect[6,7].Chemoradiotherapy has been reported to be effective in angiosarcoma especially for cutaneous angiosarcoma[8].However,evidence for the efficacy and safety of pal-liative cytotoxic CT is still limited.Therefore,here,we present our analysis based on the clinical features,tumor characteristics,treatment and outcomes of angiosarcoma patients in an attempt to investigate the significant prog-nostic factors and efficient therapeutics in real clinical practice.展开更多
基金This study was supported by a grant of the Korean Health Technology R&D Project,Ministry of Health&Welfare,Republic of Korea(HI14C1061)by a Grant 2018-430 from the Asan Institute for Life Sciences,Asan Medical Center,Seoul,Korea.
文摘Dear Editor,Angiosarcoma is a rare malignancy,which accounts for approximately 1%-2%of soft-tissue sarcomas[1].It can occur at any site within the human body.Some research-ers suggested that site distribution may be different between Eastern Asian and Western countries[1].Sev-eral factors,such as age,stage at diagnosis,performance status,site of the disease,histological grade,tumor size,and visceral involvement,were suggested as prognos-tic factors in angiosarcoma[2-5].However,there is still controversy regarding to which prognostic factors are significantly important.As there are no randomized clinical trials for angiosarcoma,its treatments are guided based on guidelines of soft-tissue sarcoma or the results of several retrospective studies.Radical surgery is the preferred treatment for angiosarcoma[2-4].Some stud-ies suggested that receiving adjuvant chemotherapy(CT)is associated with better outcome[5],while other studies have shown that adjuvant CT has no significant effect[6,7].Chemoradiotherapy has been reported to be effective in angiosarcoma especially for cutaneous angiosarcoma[8].However,evidence for the efficacy and safety of pal-liative cytotoxic CT is still limited.Therefore,here,we present our analysis based on the clinical features,tumor characteristics,treatment and outcomes of angiosarcoma patients in an attempt to investigate the significant prog-nostic factors and efficient therapeutics in real clinical practice.
