Objective: To explore the effect of gene polymorphism locus rs12794714 on allergic rhinitis in hainan province, providing reference for genetic diagnosis and prevention. Methods:From March 2017 to December 2017, 94 lo...Objective: To explore the effect of gene polymorphism locus rs12794714 on allergic rhinitis in hainan province, providing reference for genetic diagnosis and prevention. Methods:From March 2017 to December 2017, 94 local patients with Allergic rhinitis in hainan and 113 healthy people who were admitted to the first affiliated hospital of hainan medical college during the physical examination in the physical examination department of hainan medical college were selected. Statistical software SPSS 25.0 was used to conduct inter-group differentiation analysis on genotypes and alleles, and P<0.05 was considered to be statistically different. Results: all the polymorphisms of rs12794714 in hainan population could be detected with the distribution frequency of aa-ag and GG in the Allergic rhinitis group of 20.2%, 46.8%and 33%, and in the control group of 18.6%, 38% and 43.4%. Codominant model, dominant model, recessive model and superdominant model validation were not statistically significant. The distribution frequencies of alleles A and G were 54% and 46% in the experimental group, 63% and 37% in the control group, with no statistical difference. Conclusion: rs12794714 single nucleotide polymorphism has no significant effect on the pathogenesis of Allergic rhinitis in hainan province.展开更多
基金Hainan Provincial Natural Science Foundation of China(817323,817145).
文摘Objective: To explore the effect of gene polymorphism locus rs12794714 on allergic rhinitis in hainan province, providing reference for genetic diagnosis and prevention. Methods:From March 2017 to December 2017, 94 local patients with Allergic rhinitis in hainan and 113 healthy people who were admitted to the first affiliated hospital of hainan medical college during the physical examination in the physical examination department of hainan medical college were selected. Statistical software SPSS 25.0 was used to conduct inter-group differentiation analysis on genotypes and alleles, and P<0.05 was considered to be statistically different. Results: all the polymorphisms of rs12794714 in hainan population could be detected with the distribution frequency of aa-ag and GG in the Allergic rhinitis group of 20.2%, 46.8%and 33%, and in the control group of 18.6%, 38% and 43.4%. Codominant model, dominant model, recessive model and superdominant model validation were not statistically significant. The distribution frequencies of alleles A and G were 54% and 46% in the experimental group, 63% and 37% in the control group, with no statistical difference. Conclusion: rs12794714 single nucleotide polymorphism has no significant effect on the pathogenesis of Allergic rhinitis in hainan province.
