The following letter to the editor highlights the article“Effects of vitamin D supplementation on glucose and lipid metabolism in patients with type 2 diabetes mellitus and risk factors for insulin resistance”in Wor...The following letter to the editor highlights the article“Effects of vitamin D supplementation on glucose and lipid metabolism in patients with type 2 diabetes mellitus and risk factors for insulin resistance”in World J Diabetes 2023 Oct 15;14(10):1514-1523.It is necessary to explore the role of vitamin family members in insulin resistance and diabetes complications.展开更多
Objective: This study assessed the methodological quality of systematic reviews/meta-analysis of the effectiveness of probiotics against irritable bowel syndrome (IBS) using the accepted methodological quality assessm...Objective: This study assessed the methodological quality of systematic reviews/meta-analysis of the effectiveness of probiotics against irritable bowel syndrome (IBS) using the accepted methodological quality assessment scale AMSTAR and explored the factors that influenced the quality of methodology. It was designed to provide a reference for future research and systematic reviews/metaanalysis. Methods: The methodological quality of existing systematic reviews/meta-analysis was evaluated using the AMSTAR scale. Influencing factors of methodological quality were statistically analyzed using RevMan 5.3 software. The included systematic reviews/metaanalysis must include the following characteristics:(1) methods using systematic evaluation/meta-analysis,(2) probiotic intervention, and (3) language limitation to Chinese and English. Results: The AMSTAR score was 5-9 (7.42 ± 1.22), and the quality is above average. The factors affecting the methodological quality are the number of authors and whether they cooperate with the institution. Conclusions: Studies have shown that current systematic reviews/meta-analysis of the effectiveness of probiotics on IBS does not fully comply with methodological quality standards, and therefore the methodological quality of research in this area needs to be strengthened. To better clarify how probiotics affect IBS, future systematic reviews and meta-analyses should not only follow methodological quality standards but also include more effective outcome measures, and they should focus more on the discussion of research results. We look forward to the development of higher-quality randomized controlled trials in the future.展开更多
BACKGROUND Metaplastic breast carcinoma(MBC)is a rare subtype of invasive breast cancer comprising malignant epithelial and mesenchymal cells.Compared with other invasive breast cancers,MBC is not only histologically ...BACKGROUND Metaplastic breast carcinoma(MBC)is a rare subtype of invasive breast cancer comprising malignant epithelial and mesenchymal cells.Compared with other invasive breast cancers,MBC is not only histologically distinctly heterogeneous but also has a rapid and aggressive growth pattern,which leads to a significant risk of recurrence and mortality.CASE SUMMARY In this study,we report the case of a patient with a large left breast mass diagnosed with bilateral invasive ductal carcinoma in both breasts after a preoperative core needle aspiration biopsy of the bilateral breast mass.The patient received neoadjuvant chemotherapy and underwent bilateral breast modified radical mastectomy.Postoperative pathology suggested carcinosarcoma with predominantly chondrosarcoma in the left breast and invasive ductal carcinoma(luminal B)in the right breast.As the patient did not achieve complete pathological remission after six cycles of neoadjuvant chemotherapy,we administered six months of intensive capecitabine treatment.Then the patient was switched to continuous treatment with endocrine therapy using letrozole+goserelin,and the patient is currently in stable condition.However,as MBC of the breast is concurrently diagnosed with chondrosarcoma differentiation,our case is sporadic.CONCLUSION Given the variety of immunohistochemical types of bilateral breast cancer,achieving effective chemotherapy should be a key research focus.展开更多
Objective:To systematically review the influence of psychological intervention of midwives on the delivery mode and outcomes.Methods:Databases including Cochrane Library,PubMed,Medline,EMBASE,CINAHL,CNKI,Wangfang,and ...Objective:To systematically review the influence of psychological intervention of midwives on the delivery mode and outcomes.Methods:Databases including Cochrane Library,PubMed,Medline,EMBASE,CINAHL,CNKI,Wangfang,and VIP were searched for randomized controlled trials studying the effects of midwife-led psychological nursing on puerpera.Two evaluators independently searched and screened the papers,extracted relevant data,and quality assessment of the included studies,followed by a meta-analysis of the papers using RevMan 5.3 software.Results:12 studies with 1,395 patients were included.The results of the meta-analysis showed that compared to conventional nursing,midwife-led psychological intervention can improve the number of people who choose natural delivery[Z=7.53,95%CI(2.07,3.45),P<0.001],shorten the duration of the first stage of delivery[Z=45.10,95%CI(-4.43,-4.06),P<0.001),reduce postpartum hemorrhage after delivery for two hours[Z=21.68,95%CI(-63.92,-53.32),P<0.001];these differences were statistically significant.Conclusion:Psychological interventions led by midwives can improve the natural delivery rate of pregnant women,shorten the duration of the first stage of delivery,and decrease postpartum hemorrhage after delivery for two hours;thus,it can be popularized for clinical use.展开更多
Objective:To evaluate the methodological and reporting quality of systematic reviews and meta-analyses(SRs/MAs)in the nasogastric and nasojejunal enteral nutrition for severe acute pancreatitis(SAP).Methods:The SRs/MA...Objective:To evaluate the methodological and reporting quality of systematic reviews and meta-analyses(SRs/MAs)in the nasogastric and nasojejunal enteral nutrition for severe acute pancreatitis(SAP).Methods:The SRs/MAs of nasogastric and nasojejunal enteral nutrition for SAP published in the journal before July.1st 2018 were identified by searching the databases of OVID,Cochrane Library,Wiley,PubMed,CNKI,Wanfang Data and VIP.The methodological and reporting quality of included studies was respectively assessed by AMSTAR 2 scale and PRISMA statement.Results:A total of 6 articles included at last.(1)Several issues of methodological quality in 6 studies were reviewed,such as:no prior design,comprehensive searching strategy,assessment of publication bias,the reason for incorporating the type of research design,or the statement of conflict of interest.(2)The average PRISMA score is 18.83±1.97(17-22).Results on the quality of reporting evaluation showed that 5 SRs/MAs were rated as moderate and 1 as high.What’s more,we assessed the quality of indicators of the result by GRADE,but the grade was low.Conclusion:The quality of the involved studies published at home and abroad is uneven,so it is necessary to seek for further improvement of methodology and standardization of reporting to provide high-quality support for evidenced-based decision.展开更多
Objective: To systematically evaluate the efficacy of moxibustion in the treatment of cancer-related fatigue (CRF). Methods: Randomized controlled trials (RCTs) using moxibustion to treat cancer-related fatigue in Coc...Objective: To systematically evaluate the efficacy of moxibustion in the treatment of cancer-related fatigue (CRF). Methods: Randomized controlled trials (RCTs) using moxibustion to treat cancer-related fatigue in Cochrane Library, PubMed, China Knowledge Network, Wanfang and VIP databases was searched. Two reviewers independently searched, reviewed the literature, extracted data, and evaluated the methodological quality. RevMan5.3 software was used for meta-analysis. Results: A total of 942 patients were included in 11 randomized controlled trials. The meta-analysis results showed that moxibustion can reduce fatigue score [MD =-2.04, 95% CI (-4.06,-0.33), P < 0.001], improve the score of quality of life QLQ-C30 [(MD = 8.44, 95% CI (1.85, 15.03), P < 0.001], also could boost the number of important immune-system cellular, such as CD3 [MD = 7.82, 95% CI (3.14, 12.49), P = 0.01], CD8 [MD =-3.15, 95% CI (-11.36, 5.06), P < 0.001], NK cells [MD=5.88, 95% CI (3.56, 8.20), P = 0.01];Conclusion: Moxibustion can improve the degree of cancer-related fatigue, improve the quality of life and enhance immune function.展开更多
This paper reviews the research progress of “person-centered” nursing,and provides reference for the development of “person-centered” nursing in China.Currently,foreign scales have been developed to measure “pers...This paper reviews the research progress of “person-centered” nursing,and provides reference for the development of “person-centered” nursing in China.Currently,foreign scales have been developed to measure “person-centered” nursing,such as Individualized Care Scale,P-CA,Assess Health Care Providers’ Implementation of Patient-Cen,Person-centered Critical Care Nursing and Human-based Perioperative Care Scale.The “Person-centered” nursing model has been widely used in clinical nursing and nursing management.Studies have shown that “person-centered” nursing can improve patient satisfaction and promote the physical and mental health of patients.At the same time,the combination of “person-centered” nursing and teaching promotes the innovation of medical education medicine,and its combination with architecture promotes the progress of hospital construction.Future research should focus on the overall layout of hospitals and wards,use more holistic means of psychosomatic medicine to set up more comprehensive humanistic concepts such as accompanying family members area,improve the breadth and depth of humanistic nursing field,and promote the development of humanistic nursing in China.展开更多
Objective:To design and apply a multifunctional uniform for hemodialysis patients.The new patients’uniform is designed as a medium-to-long dress.A PVC transparent pocket locates under the right collar with the size o...Objective:To design and apply a multifunctional uniform for hemodialysis patients.The new patients’uniform is designed as a medium-to-long dress.A PVC transparent pocket locates under the right collar with the size of 6 cm x 4 cm;an oblique opening starts from the collar to the downright by 46 cm x 2 cm,with 6 ties and concealed fasteners;a 45 cm opening at the edge of both side of the sleeves,with 4 ties and concealed buttons;There is a 5 cm x 1.5 cm urinary catheter opening at the crotch,with 2 cross-opening perforations and concealed buttons.The lower thighs of both sides of the patients’uniform,at which an elastic tie and a concealed button locate,are not sutured.Therefore,during hemodialysis,patients can fix the vascular access,prevent such adverse events as channel compression and detachment,improve the safety,comfort and privacy of dialysis patients,and reduce the incidence of complications such as infection compared with the traditional uniform.The design of the new multifunctional uniform for hemodialysis patients is reasonable,which ensures the safety of hemodialysis patients and is suitable for clinical application and promotion.展开更多
Background Previous studies showed that soluble IL-2Rαis an important marker of cellular immune activation and might be a marker of treatment efficacy for children with brucellosis.However,data regarding adult patien...Background Previous studies showed that soluble IL-2Rαis an important marker of cellular immune activation and might be a marker of treatment efficacy for children with brucellosis.However,data regarding adult patients with brucellosis were unknown.The aim of study was to explore the potential role of serum sIL-2Rαevaluating treatment responses in adult patients with brucellosis,and T cell immune status was also examined.Methods During January 2016–April 2017,30 patients with acute brucellosis from the Third People’s Hospital of Linfen in Shanxi Province and Beijing Di Tan Hospital,and 28 healthy controls were included in this study.Peripheral blood samples were collected before and after six weeks of antibiotic treatment.Serum sIL-2Rαlevels were measured by enzyme-linked immunosorbent assay,and the percentage of Th1,Th2,Tc1,Tc2,and Tregs was detected by flow cytometry after intracellular staining for cytokines(interferon-γand interleukin-4)and Foxp3 in T lymphocytes from peripheral blood.The obtained data were analyzed with Wilcoxon ranked sum tests for paired values,Mann-Whitney U-tests for comparisons between patients and healthy controls,and Spearman rank tests for correlation analyses.Results Serum sIL-2Rαlevels were significantly higher in patients than in controls(P=0.001).A significant decline was observed in patients after the cessation of treatment(P<0.001)and return to normal(P>0.05).Th1,Tc1,Th2,and Tc2 cell frequencies were higher in patients than in healthy subjects(P<0.05),while the Th1/Th2 and Tc1/Tc2 ratios were significantly lower(P=0.0305 and 0.0005,respectively)and returned to normal levels after treatment.In patients with acute brucellosis,serum sIL-2Rαlevels were negatively correlated with the Th1/Th2 ratio(r=−0.478,P=0.028),Tc1/Tc2 ratio(r=−0.677,P=0.001),and Tc1 percentage(r=−0.516,P=0.017).Serum sIL-2Rαand Tc2 percentages were positively correlated(r=0.442,P=0.045).Conclusions Based on the correlations with Th1/Th2 and Tc1/Tc2 ratios,serum sIL-2Rαlevels may reflect the immune response status.sIL-2Rαmay be a marker for therapeutic efficacy in acute brucellosis.展开更多
基金Supported by the National Natural Science Foundation of China,No.82170286Basic Research Program of Guizhou Province(Natural Sciences),No.ZK[2023]321+1 种基金Start-up Fund of Guizhou Medical University,No.J2021032Postdoctoral Research Fund of Affiliated Hospital of Guizhou Medical University,No.BSH-Q-2021-10.
文摘The following letter to the editor highlights the article“Effects of vitamin D supplementation on glucose and lipid metabolism in patients with type 2 diabetes mellitus and risk factors for insulin resistance”in World J Diabetes 2023 Oct 15;14(10):1514-1523.It is necessary to explore the role of vitamin family members in insulin resistance and diabetes complications.
基金the financial supports from the National Natural Science Foundation of China (Nos. 52004194, 51874219)the China Postdoctoral Science Foundation (No. 2019M662733)。
文摘Objective: This study assessed the methodological quality of systematic reviews/meta-analysis of the effectiveness of probiotics against irritable bowel syndrome (IBS) using the accepted methodological quality assessment scale AMSTAR and explored the factors that influenced the quality of methodology. It was designed to provide a reference for future research and systematic reviews/metaanalysis. Methods: The methodological quality of existing systematic reviews/meta-analysis was evaluated using the AMSTAR scale. Influencing factors of methodological quality were statistically analyzed using RevMan 5.3 software. The included systematic reviews/metaanalysis must include the following characteristics:(1) methods using systematic evaluation/meta-analysis,(2) probiotic intervention, and (3) language limitation to Chinese and English. Results: The AMSTAR score was 5-9 (7.42 ± 1.22), and the quality is above average. The factors affecting the methodological quality are the number of authors and whether they cooperate with the institution. Conclusions: Studies have shown that current systematic reviews/meta-analysis of the effectiveness of probiotics on IBS does not fully comply with methodological quality standards, and therefore the methodological quality of research in this area needs to be strengthened. To better clarify how probiotics affect IBS, future systematic reviews and meta-analyses should not only follow methodological quality standards but also include more effective outcome measures, and they should focus more on the discussion of research results. We look forward to the development of higher-quality randomized controlled trials in the future.
文摘BACKGROUND Metaplastic breast carcinoma(MBC)is a rare subtype of invasive breast cancer comprising malignant epithelial and mesenchymal cells.Compared with other invasive breast cancers,MBC is not only histologically distinctly heterogeneous but also has a rapid and aggressive growth pattern,which leads to a significant risk of recurrence and mortality.CASE SUMMARY In this study,we report the case of a patient with a large left breast mass diagnosed with bilateral invasive ductal carcinoma in both breasts after a preoperative core needle aspiration biopsy of the bilateral breast mass.The patient received neoadjuvant chemotherapy and underwent bilateral breast modified radical mastectomy.Postoperative pathology suggested carcinosarcoma with predominantly chondrosarcoma in the left breast and invasive ductal carcinoma(luminal B)in the right breast.As the patient did not achieve complete pathological remission after six cycles of neoadjuvant chemotherapy,we administered six months of intensive capecitabine treatment.Then the patient was switched to continuous treatment with endocrine therapy using letrozole+goserelin,and the patient is currently in stable condition.However,as MBC of the breast is concurrently diagnosed with chondrosarcoma differentiation,our case is sporadic.CONCLUSION Given the variety of immunohistochemical types of bilateral breast cancer,achieving effective chemotherapy should be a key research focus.
文摘Objective:To systematically review the influence of psychological intervention of midwives on the delivery mode and outcomes.Methods:Databases including Cochrane Library,PubMed,Medline,EMBASE,CINAHL,CNKI,Wangfang,and VIP were searched for randomized controlled trials studying the effects of midwife-led psychological nursing on puerpera.Two evaluators independently searched and screened the papers,extracted relevant data,and quality assessment of the included studies,followed by a meta-analysis of the papers using RevMan 5.3 software.Results:12 studies with 1,395 patients were included.The results of the meta-analysis showed that compared to conventional nursing,midwife-led psychological intervention can improve the number of people who choose natural delivery[Z=7.53,95%CI(2.07,3.45),P<0.001],shorten the duration of the first stage of delivery[Z=45.10,95%CI(-4.43,-4.06),P<0.001),reduce postpartum hemorrhage after delivery for two hours[Z=21.68,95%CI(-63.92,-53.32),P<0.001];these differences were statistically significant.Conclusion:Psychological interventions led by midwives can improve the natural delivery rate of pregnant women,shorten the duration of the first stage of delivery,and decrease postpartum hemorrhage after delivery for two hours;thus,it can be popularized for clinical use.
文摘Objective:To evaluate the methodological and reporting quality of systematic reviews and meta-analyses(SRs/MAs)in the nasogastric and nasojejunal enteral nutrition for severe acute pancreatitis(SAP).Methods:The SRs/MAs of nasogastric and nasojejunal enteral nutrition for SAP published in the journal before July.1st 2018 were identified by searching the databases of OVID,Cochrane Library,Wiley,PubMed,CNKI,Wanfang Data and VIP.The methodological and reporting quality of included studies was respectively assessed by AMSTAR 2 scale and PRISMA statement.Results:A total of 6 articles included at last.(1)Several issues of methodological quality in 6 studies were reviewed,such as:no prior design,comprehensive searching strategy,assessment of publication bias,the reason for incorporating the type of research design,or the statement of conflict of interest.(2)The average PRISMA score is 18.83±1.97(17-22).Results on the quality of reporting evaluation showed that 5 SRs/MAs were rated as moderate and 1 as high.What’s more,we assessed the quality of indicators of the result by GRADE,but the grade was low.Conclusion:The quality of the involved studies published at home and abroad is uneven,so it is necessary to seek for further improvement of methodology and standardization of reporting to provide high-quality support for evidenced-based decision.
文摘Objective: To systematically evaluate the efficacy of moxibustion in the treatment of cancer-related fatigue (CRF). Methods: Randomized controlled trials (RCTs) using moxibustion to treat cancer-related fatigue in Cochrane Library, PubMed, China Knowledge Network, Wanfang and VIP databases was searched. Two reviewers independently searched, reviewed the literature, extracted data, and evaluated the methodological quality. RevMan5.3 software was used for meta-analysis. Results: A total of 942 patients were included in 11 randomized controlled trials. The meta-analysis results showed that moxibustion can reduce fatigue score [MD =-2.04, 95% CI (-4.06,-0.33), P < 0.001], improve the score of quality of life QLQ-C30 [(MD = 8.44, 95% CI (1.85, 15.03), P < 0.001], also could boost the number of important immune-system cellular, such as CD3 [MD = 7.82, 95% CI (3.14, 12.49), P = 0.01], CD8 [MD =-3.15, 95% CI (-11.36, 5.06), P < 0.001], NK cells [MD=5.88, 95% CI (3.56, 8.20), P = 0.01];Conclusion: Moxibustion can improve the degree of cancer-related fatigue, improve the quality of life and enhance immune function.
文摘This paper reviews the research progress of “person-centered” nursing,and provides reference for the development of “person-centered” nursing in China.Currently,foreign scales have been developed to measure “person-centered” nursing,such as Individualized Care Scale,P-CA,Assess Health Care Providers’ Implementation of Patient-Cen,Person-centered Critical Care Nursing and Human-based Perioperative Care Scale.The “Person-centered” nursing model has been widely used in clinical nursing and nursing management.Studies have shown that “person-centered” nursing can improve patient satisfaction and promote the physical and mental health of patients.At the same time,the combination of “person-centered” nursing and teaching promotes the innovation of medical education medicine,and its combination with architecture promotes the progress of hospital construction.Future research should focus on the overall layout of hospitals and wards,use more holistic means of psychosomatic medicine to set up more comprehensive humanistic concepts such as accompanying family members area,improve the breadth and depth of humanistic nursing field,and promote the development of humanistic nursing in China.
文摘Objective:To design and apply a multifunctional uniform for hemodialysis patients.The new patients’uniform is designed as a medium-to-long dress.A PVC transparent pocket locates under the right collar with the size of 6 cm x 4 cm;an oblique opening starts from the collar to the downright by 46 cm x 2 cm,with 6 ties and concealed fasteners;a 45 cm opening at the edge of both side of the sleeves,with 4 ties and concealed buttons;There is a 5 cm x 1.5 cm urinary catheter opening at the crotch,with 2 cross-opening perforations and concealed buttons.The lower thighs of both sides of the patients’uniform,at which an elastic tie and a concealed button locate,are not sutured.Therefore,during hemodialysis,patients can fix the vascular access,prevent such adverse events as channel compression and detachment,improve the safety,comfort and privacy of dialysis patients,and reduce the incidence of complications such as infection compared with the traditional uniform.The design of the new multifunctional uniform for hemodialysis patients is reasonable,which ensures the safety of hemodialysis patients and is suitable for clinical application and promotion.
文摘Background Previous studies showed that soluble IL-2Rαis an important marker of cellular immune activation and might be a marker of treatment efficacy for children with brucellosis.However,data regarding adult patients with brucellosis were unknown.The aim of study was to explore the potential role of serum sIL-2Rαevaluating treatment responses in adult patients with brucellosis,and T cell immune status was also examined.Methods During January 2016–April 2017,30 patients with acute brucellosis from the Third People’s Hospital of Linfen in Shanxi Province and Beijing Di Tan Hospital,and 28 healthy controls were included in this study.Peripheral blood samples were collected before and after six weeks of antibiotic treatment.Serum sIL-2Rαlevels were measured by enzyme-linked immunosorbent assay,and the percentage of Th1,Th2,Tc1,Tc2,and Tregs was detected by flow cytometry after intracellular staining for cytokines(interferon-γand interleukin-4)and Foxp3 in T lymphocytes from peripheral blood.The obtained data were analyzed with Wilcoxon ranked sum tests for paired values,Mann-Whitney U-tests for comparisons between patients and healthy controls,and Spearman rank tests for correlation analyses.Results Serum sIL-2Rαlevels were significantly higher in patients than in controls(P=0.001).A significant decline was observed in patients after the cessation of treatment(P<0.001)and return to normal(P>0.05).Th1,Tc1,Th2,and Tc2 cell frequencies were higher in patients than in healthy subjects(P<0.05),while the Th1/Th2 and Tc1/Tc2 ratios were significantly lower(P=0.0305 and 0.0005,respectively)and returned to normal levels after treatment.In patients with acute brucellosis,serum sIL-2Rαlevels were negatively correlated with the Th1/Th2 ratio(r=−0.478,P=0.028),Tc1/Tc2 ratio(r=−0.677,P=0.001),and Tc1 percentage(r=−0.516,P=0.017).Serum sIL-2Rαand Tc2 percentages were positively correlated(r=0.442,P=0.045).Conclusions Based on the correlations with Th1/Th2 and Tc1/Tc2 ratios,serum sIL-2Rαlevels may reflect the immune response status.sIL-2Rαmay be a marker for therapeutic efficacy in acute brucellosis.
