ACU&MOX-DATA:针灸多组学异源数据融合分析平台

本文介绍了名为ACU&MOX-DATA(Acupuncture&moxibustion-deep analysis to treat accurately)的针灸多组学异源数据融合分析网络平台(http://cbcb.cdutcm.edu.cn/ACU&MOX-DATA/)。该平台旨在整合分析针灸相关疾病、临床和实验室获得的异源、多层次数据,其典型特点是在中医理论指导下,收集针灸研究所获得的各种观测指标,通过异源、多层次数据融合分析的方法,实现对针灸学领域关键科学问题的集成分析和可视化解读。本文介绍了该平台目前已有的功能及未来的研究计划。

Prenatal and perinatal risk factors for solid childhood malignancies: A questionnaire-based study

Importance:Childhood solid tumors account for the highest proportion of childhood cancers and are one of the leading causes of death in childhood.However,their pathogenesis is unclear.Objective:To explore prenatal and perinatal risk factors for solid malignancies in children.Methods:We enrolled 71 consecutive pediatric patients (44 boys and 27 girls;median age,30 months) with solid tumors who were diagnosed and treated at our center from January 2013 to December 2016 as the case group.We also enrolled 211 age-and residence-matched healthy children (ratio of approximately 3:1 with the case group) as the control group.We conducted a questionnaire-based survey with the parents of these 282 children.Univariate and multivariate conditional logistic regression analyses of the collected data were performed.Results:Confirmed solid malignancies included neuroblastoma (n =32),rhabdomyosarcoma (n =18),retinoblastoma (n =7),renal tumors (n =3),and other tumors (n =11).Risk factors for solid childhood tumors in the univariate analysis were the parents' age,gravidity,parity,abortion history,vaginal bleeding,family history of malignancy,and prenatal use of folic acid or hematinics/iron supplements (P ＜ 0.05),and those in the multivariate analysis were higher parity (odds ratio [OR],2.482;95％ confidence interval [CI],1.521-4.048),family history of malignancy (OR,3.667;95％ CI,1.679-8.009),and prenatal use of hematinics/iron supplements (OR,2.882;95％ CI,1.440-5.767).In contrast,use of prenatal folic acid was protective (OR,0.334;95％ CI,0.160-0.694).Interpretation:A family history of malignancy,use of prenatal hematinics/iron supplements,and higher parity are risk factors for solid childhood tumors,whereas use of prenatal folic acid is a protective factor.

Two-dimensional layered architecture constructing energy and phonon blocks for enhancing thermoelectric performance of InSb

InSb is a narrow-bandgap semiconductor with a zinc blende structure and has been wildly applied in photodetectors, infrared thermal imaging, and Hall devices. The facts of decent band structure, ultrahigh electron mobility,and nontoxic nature indicate that InSb may be a potential mid-temperature thermoelectric material. The critical challenges of InSb, such as high thermal conductivity and small Seebeck coefficient, have induced its ultrahigh lattice thermal conductivity, and thus low ZT values. In view of this, we have developed a competitive strategy typified by the cost-efficient nanocompositing of z wt% QSe_(2)(Q = Sn, W). Specifically, the Q_(In)^(+) and Se_(Sb)^(+) point defects were introduced in the In Sb system by nanocompositing the vested two-dimensional layered QSe_(2). In addition, the enlarged valence band maximum of intrinsic WSe_(2)acted as ladders can scatter a fair number of hole carriers, resulting in the relatively enhanced Seebeck coefficient of high temperature. Moreover, the disorderly distributed nanosheets/particles, and dislocations acting as obstacles can effectively delay the heat flow diffusion, inducing the strong scattering of thermal phonons. Consequently, an enhanced power factor of ~33.3 μW cm^(-1)K^(-2) and ZT value of~0.82 at 733 K have been achieved in the 3% WSe_(2)sample,companied with the engineering output power density ω_(max)~233 μW cm^(-1) and thermoelectric conversion efficiency η~5.2%. This artificially designed approach indicated by suited nanocompositing can integrate several engineering strategies such as point defects, nanoengineering, and energy filtering into one, providing a reference to optimize the thermoelectric performance of other thermoelectric systems.