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A strength model for cement-stabilized mud subjected to various curing temperatures and its early-stage quality control
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作者 sijie liu Rongjun Zhang +1 位作者 Junjie Zheng Lin Chen 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第11期4727-4741,共15页
The influence of curing temperature on the strength development of cement-stabilized mud has been well documented in terms of strength-increase rate and ultimate strength.However,the strength development model is not ... The influence of curing temperature on the strength development of cement-stabilized mud has been well documented in terms of strength-increase rate and ultimate strength.However,the strength development model is not mature for the extremely early stages.In addition,there is a lack of studies on quality control methods based on early-stage strength development.This paper presents a strength model for cement-stabilized mud to address these gaps,considering various curing temperatures and early-stage behaviors.In this study,a series of laboratory experiments was conducted on two types of muds treated with Portland blast furnace cement and ordinary Portland cement under four different temperatures.The results indicate that elevated temperatures expedite strength development and lead to higher long-term strength.The proposed model,which combines a three-step conversion process and a hyperbolic model at the reference temperature,enables accurate estimate of the strength development for cement-treated mud with any proportions cured under various temperatures.With this model,a practical early quality control method is introduced for applying cement-stabilized mud in field projects.The back-analysis parameters obtained from a 36-h investigation at temperature of 60C demonstrated a sufficient accuracy in predicting strength levels in practical applications. 展开更多
关键词 Cement-stabilized mud Curing temperature Early stage Quality control Strength development
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Selective photocatalytic aerobic oxidative cleavage of lignin C–O bonds over sodium lignosulfonate modified Fe_(3)O_(4)/TiO_(2) 被引量:1
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作者 Kejia Wu Jinrong Liang +4 位作者 sijie liu Yimin Huang Minglong Cao Qiang Zeng Xuehui Li 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第9期89-100,共12页
Lignocellulose shows significantly potential in sustainable conversion to high-quality fuel and valueadded chemicals with the demands for realizing the rapid cycle of carbon resources and helping to reach carbon neutr... Lignocellulose shows significantly potential in sustainable conversion to high-quality fuel and valueadded chemicals with the demands for realizing the rapid cycle of carbon resources and helping to reach carbon neutrality in nature.Selective tailoring of α-O-4,β-O-4,etc.linkages in lignin has always been viewed as "death blow" for its depolymerization.Herein,novel sodium lignosulfonate(SL) modified Fe_(3)O_(4)/TiO_(2)(SL-Fe_(3)O_(4)/TiO_(2)) spherical particles have been developed and used as catalysts for selectively photocatalytic oxidative cleavage of organosolv lignin.As expected,80% selective conversion of lignin in C2-C4 esters has been achieved,while C-O bonds in lignin model compounds can be effectively cleaved.Other than normal hydroxyl radical-mediated photocatalytic depolymerization of lignin over TiO_(2)-based materials,in this contribution,mechanism studies indicate that photogenerated holes and superoxide anion radicals are main active species,which trigger the cleavage of α/β-O-4 bond,and the isotopelabeling study confirms the crucial factor of C_β-H dehydrogenation in cleavage of β-O-4 bonds. 展开更多
关键词 LIGNIN Photocatalytic oxidation Selective cleavage Titanium dioxide
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泛素连接酶Brl2在DNA双链断裂修复中的作用分析
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作者 刘晓琴 常斐然 +2 位作者 刘思杰 伍斐 孔道春 《遗传》 CAS CSCD 北大核心 2022年第7期609-617,共9页
组蛋白H2B单泛素化在基因转录、DNA复制及损伤修复中发挥着重要的调控作用。在裂殖酵母(Schizosaccharomyces pombe)中,Brl2作为一个泛素化连接酶,调节H2B的119位赖氨酸的单泛素化。目前,有关Brl2在DNA损伤修复中的作用研究较少,本研究... 组蛋白H2B单泛素化在基因转录、DNA复制及损伤修复中发挥着重要的调控作用。在裂殖酵母(Schizosaccharomyces pombe)中,Brl2作为一个泛素化连接酶,调节H2B的119位赖氨酸的单泛素化。目前,有关Brl2在DNA损伤修复中的作用研究较少,本研究利用药物喜树碱(camptothecin,CPT)处理裂殖酵母产生高毒性的DNA双链断裂(DNA double-strand breaks,DSBs),探索Brl2在DSB修复过程中的作用。研究发现,brl2基因缺失的菌株对CPT高度敏感,并导致细胞内DNA自发重组频率下降。荧光分析表明Brl2和重组修复蛋白Rad52共定位到DSB处,且Brl2促进Rad52在DSB处的募集。在CPT产生的DSB条件下,Brl2会发生磷酸化。以上研究发现揭示了Brl2在DSB修复过程中起重要作用,为具体阐明Brl2在DNA同源重组及双链断裂修复的分子机制奠定了进一步研究的基础。 展开更多
关键词 组蛋白H2B Brl2 DNA双链断裂修复 喜树碱 裂殖酵母
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THE STABILITY OF THE DELTA WAVE TO PRESSURELESS EULER EQUATIONS WITH VISCOUS AND FLUX PERTURBATIONS
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作者 sijie liu Wancheng SHENG 《Acta Mathematica Scientia》 SCIE CSCD 2022年第4期1519-1535,共17页
This paper is concerned with the pressureless Euler equations with viscous and flux perturbations.The existence of Riemann solutions to the pressureless Euler equations with viscous and flux perturbations is obtained.... This paper is concerned with the pressureless Euler equations with viscous and flux perturbations.The existence of Riemann solutions to the pressureless Euler equations with viscous and flux perturbations is obtained.We show the stability of the delta wave of the pressureless Euler equations to the perturbations;that is,the limit solution of the pressureless Euler equations with viscous and flux perturbations is the delta wave solution of the pressureless Euler equations as the viscous and flux perturbation simultaneously vanish in the case u_(-)> u_(+). 展开更多
关键词 Pressureless Euler equations stability of the delta wave viscous perturbation and flux perturbation
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ccdc141 is required for left-right axis development by regulating cilia formation in the Kupffer's vesicle of zebrafish
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作者 Pengcheng Wang Wenxiang Shi +6 位作者 sijie liu Yunjing Shi Xuechao Jiang Fen Li Sun Chen Kun Sun Rang Xu 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2024年第9期934-946,共13页
Laterality is a crucial physiological process intricately linked to the cilium-centrosome complex during embryo development.Defects in the process can result in severe organ mispositioning.Coiled-coil domain containin... Laterality is a crucial physiological process intricately linked to the cilium-centrosome complex during embryo development.Defects in the process can result in severe organ mispositioning.Coiled-coil domain containing 141(CCDC141)has been previously known as a centrosome-related gene,but its role in left-right(LR)asymmetry has not been characterized.In this study,we utilize the zebrafish model and human exome analysis to elucidate the function of ccdc141 in laterality defects.The knockdown of ccdc141 in zebrafish disrupts early LR signaling pathways,cilia function,and Kupffer's vesicle formation.Unlike ccdc141-knockdown embryos exhibiting aberrant LR patterns,ccdc141-null mutants show no apparent abnormality,suggesting a genetic compensation response effect.In parallel,we observe a marked reduction inα-tubulin acetylation levels in the ccdc141 crispants.The treatment with histone deacetylase(HDAC)inhibitors,particularly the HDAC6 inhibitor,rescues the ccdc141 crispant phenotypes.Furthermore,exome analysis of 70 patients with laterality defects reveals an increased burden of CCDC141 mutations,with in-vivo studies verifying the pathogenicity of the patient mutation CCDC141-R123G.Our findings highlight the critical role of ccdc141 in ciliogenesis and demonstrate that CCDC141 mutations lead to abnormal LR patterns,identifying it as a candidate gene for laterality defects. 展开更多
关键词 Left-right axis CILIA WES Laterality defects ZEBRAFISH CCDC141
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In-plane isotropic separator-induced highly efficient sodium plating for unlocking the fast-charging capability of anode-free sodium battery at practical conditions
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作者 Haocheng Yuan Kaihua Wen +6 位作者 Shundong Guan Ying Liang Yu-Hsien Wu sijie liu Dengfeng Yu Liangliang Li Ce-Wen Nan 《Journal of Materiomics》 SCIE CSCD 2024年第3期643-651,共9页
Ether-based electrolytes with excellent reductive stability are compatible with sodium(Na)metal an-odes,which enables stable cycling for Na metal batteries even in an anode-free configuration.However,the practical app... Ether-based electrolytes with excellent reductive stability are compatible with sodium(Na)metal an-odes,which enables stable cycling for Na metal batteries even in an anode-free configuration.However,the practical applications of anode-free sodium batteries(AFSBs)with a high theoretical energy density are restricted by the low-rate capability and limited cycle life.Here we demonstrate that the mechanical properties of the separators,which have been overlooked in previous studies,can significantly affect the cycling stability of AFSBs due to the intrinsic softness of Na and the large volume variation of AFSBs during Na plating/stripping.By using various separators including polypropylene(PP),polyethylene(PE),PP/PE/PP tri-layer,and aluminum oxide-coated separators,we find that the balanced elastic moduli of the separator along the machine direction and transverse direction are crucial for enabling highly effi-cient Na plating and unlocking the 4 C fast-charging capability of the AFSBs at practical conditions including a high cathode active mass loading(13.5 mg/cm^(2)),lean electrolyte addition(8.8 mL/cm^(2)),and no pre-sodiation process.This study provides an important separator design principle for the develop-ment of high-rate and long-cycle-life AFSBs. 展开更多
关键词 Sodium metal Elastic modulus Ether electrolyte Sodium battery Short circuit
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Modification of solid electrolyte interface layer between PVDF-based electrolyte and lithium anode
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作者 Ying Liang Jie Zhang +9 位作者 Shundong Guan Kaihua Wen Chuangjie Guo Yu-Hsien Wu Haocheng Yuan sijie liu Ying Qi Wenbin Mo Xue Zhang Ce-Wen Nan 《Journal of Materiomics》 SCIE CSCD 2024年第4期880-888,共9页
Poly(vinylidene fluoride)(PVDF)-based polymer electrolytes(PEs)with good electrochemical performance and processability as well as low-cost advantage,have great potential applications in solid-state lithium(Li)metal b... Poly(vinylidene fluoride)(PVDF)-based polymer electrolytes(PEs)with good electrochemical performance and processability as well as low-cost advantage,have great potential applications in solid-state lithium(Li)metal batteries(SSLMBs).PVDF-based PEs are generally produced by employing a solution-casting approach with N,N-dimethylformamide(DMF)as the solvent,accompanied by the formation of[DMF-Li^(+)]complex,which facilitates the Li-ion transport.However,the residual DMF can react continuously with lithium(Li)metal,thereby deteriorating the interface layer in the middle of the PVDF-based PEs and Li anodes.Herein,we introduce propylene carbonate(PC)into the PVDF-based PEs to regulate the solvation structure and stabilize the interface layer between the PEs and Li anodes.PC accelerates the dissociation of lithium oxalyldifluoroborate(LiODFB).Consequently,“lithium propylene dicarbonate(LPDC)‒B-O”oligomer forms as the interfacial layer with high tenacity,homogeneity,and densification,which improves the interfacial contact and suppresses the continuous reaction between the residual DMF and Li anode.We further demonstrate that the PVDF-based PE prepared with DMF-PC mix-solvents shows improved room-temperature ionic conductivity(1.18×10^(-3) S/cm),enhanced stability against electrodes,and superior cycling performance in LiCoO_(2)-based SSLMBs(maintaining 84% of the initial discharge capacity after 300 cycles). 展开更多
关键词 Solid-state battery Lithium metal Poly(vinylidene fluoride)electrolyte Propylene carbonate SEI layer
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A Cullin 5-based complex serves as an essential modulator of ORF9b stability in SARS-CoV-2 replication
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作者 Yuzheng Zhou Zongpeng Chen +22 位作者 sijie liu Sixu liu Yujie Liao Ashuai Du Zijun Dong Yongxing Zhang Xuan Chen Siyi Tao Xin Wu Aroona Razzaq Gang Xu De-an Tan Shanni Li Youwen Deng Jian Peng Shuyan Dai Xu Deng Xianwen Zhang Taijiao Jiang Zheng Zhang Gong Cheng Jincun Zhao Zanxian Xia 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2024年第7期3112-3129,共18页
The ORF9b protein,derived from the nucleocapsid’s open-reading frame in both SARS-CoV and SARS-CoV-2,serves as an accessory protein crucial for viral immune evasion by inhibiting the innate immune response.Despite it... The ORF9b protein,derived from the nucleocapsid’s open-reading frame in both SARS-CoV and SARS-CoV-2,serves as an accessory protein crucial for viral immune evasion by inhibiting the innate immune response.Despite its significance,the precise regulatory mechanisms underlying its function remain elusive.In the present study,we unveil that the ORF9b protein of SARS-CoV-2,including emerging mutant strains like Delta and Omicron,can undergo ubiquitination at the K67 site and subsequent degradation via the proteasome pathway,despite certain mutations present among these strains.Moreover,our investigation further uncovers the pivotal role of the translocase of the outer mitochondrial membrane 70(TOM70)as a substrate receptor,bridging ORF9b with heat shock protein 90 alpha(HSP90α)and Cullin 5(CUL5)to form a complex.Within this complex,CUL5 triggers the ubiquitination and degradation of ORF9b,acting as a host antiviral factor,while HSP90αfunctions to stabilize it.Notably,treatment with HSP90 inhibitors such as GA or 17-AAG accelerates the degradation of ORF9b,leading to a pronounced inhibition of SARS-CoV-2 replication.Single-cell sequencing data revealed an up-regulation of HSP90αin lung epithelial cells from COVID-19 patients,suggesting a potential mechanism by which SARS-CoV-2 may exploit HSP90αto evade the host immunity.Our study identifies the CUL5-TOM70-HSP90αcomplex as a critical regulator of ORF9b protein stability,shedding light on the intricate host–virus immune response dynamics and offering promising avenues for drug development against SARS-CoV-2 in clinical settings. 展开更多
关键词 STABILITY MODULATOR offering
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从纳米酶的视角探究农业食品安全的奥秘 被引量:1
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作者 李跃春 黄伦杰 +5 位作者 杜婷 石珑华 刘思杰 孙菁 张道宏 王建龙 《Science Bulletin》 SCIE EI CAS CSCD 2023年第5期441-443,共3页
Global climate changes,such as extreme weather,sea levels rise,and biodiversity decline,have destructive impacts on the global agrofood system,in terms of crop yield,agrofood quality and consumer safety.Those stressed... Global climate changes,such as extreme weather,sea levels rise,and biodiversity decline,have destructive impacts on the global agrofood system,in terms of crop yield,agrofood quality and consumer safety.Those stressed conditions and environmental pollution for crop and agrofood prompt us to take immediate action to develop a whole-new-era agrofood system from the perspective of sustainability[1]. 展开更多
关键词 纳米酶 PROMPT CONSUMER
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离子液体催化生物质选择性转化 被引量:5
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作者 刘思洁 陆燕玲 +3 位作者 黄家荣 高梦翘 龙金星 李雪辉 《中国科学:化学》 CAS CSCD 北大核心 2021年第10期1382-1390,共9页
生物质是地球上重要的可再生资源,也是化石资源的优秀替代品.然而,由于生物质各组分的分子内和分子间存在复杂的连接键作用,生物质通常难以溶解于水或常规溶剂,这极大地限制了其高效利用.作为一种绿色溶剂和催化剂,功能化离子液体对生... 生物质是地球上重要的可再生资源,也是化石资源的优秀替代品.然而,由于生物质各组分的分子内和分子间存在复杂的连接键作用,生物质通常难以溶解于水或常规溶剂,这极大地限制了其高效利用.作为一种绿色溶剂和催化剂,功能化离子液体对生物质具有优良的溶解性能与催化活性,有望成为生物质高效利用的重要反应介质或催化剂.本文详细介绍了本课题组近年来利用离子液体催化生物质选择性转化制备小分子化学品方面所取得的研究进展,并对该领域近期所取得的代表性研究成果进行了综述与评论;同时,对目前离子液体用于生物质转化所面临的挑战及可能的解决途径进行了展望. 展开更多
关键词 离子液体 生物质 催化转化 化学品
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High-conductivity free-standing Li_(6)PS_(5)Cl/poly(vinylidene difluoride)composite solid electrolyte membranes for lithium-ion batteries 被引量:7
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作者 Shuo Wang Xue Zhang +9 位作者 sijie liu Chengzhou Xin Chuanjiao Xue Felix Richter Liangliang Li Lizhen Fan Yuanhua Lin Yang Shen Jurgen Janek Ce-Wen Nan 《Journal of Materiomics》 SCIE EI 2020年第1期70-76,共7页
Bulk-type all-solid-state batteries(ASSBs)using sulfide solid electrolyte are considered as a promising alternative to commercial lithium-ion batteries owing to their high energy density and safety.However,cell energy... Bulk-type all-solid-state batteries(ASSBs)using sulfide solid electrolyte are considered as a promising alternative to commercial lithium-ion batteries owing to their high energy density and safety.However,cell energy density is often comparatively low due to use of a thick solid electrolyte separator and a lithium alloy as anode.For achieving high-performance ASSBs,creating a thin free-standing electrolyte with high-conductivity and good cycling stability against lithium anode is essential.In this work,we present Li_(6)PS_(5)Cl/poly(vinylidene difluoride)(LPSCl/PVDF)composite electrolytes prepared by a slurry method.The influence of the PVDF content on the microstructure,morphology,ionic conductivity and activation energy of the LPSCl/PVDF electrolytes is systematically investigated.Free-standing LPSCl/PVDF membranes with a thickness of 100-120 mm and a high ionic conductivity of about 1·10^(-3) S cm^(-1) at 25℃ are obtained.After adding PVDF to the LPSCl electrolyte,the cycling stability of the LPSCl electrolyte against lithium metal improves significantly.Therefore,LPSCl/PVDF composite electrolytes are promising candidates to be used in ASSBs. 展开更多
关键词 Composite solid electrolyte Li_(6)PS_(5)Cl Poly(vinylidene difluoride)
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Dynamic prediction of over-excavation gap due to posture adjustment of shield machine in soft soil
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作者 Wenyu Yang Junjie Zheng +2 位作者 Rongjun Zhang sijie liu Wengang Zhang 《Underground Space》 SCIE EI 2024年第3期44-58,共15页
The probability analysis of ground deformation is becoming a trend to estimate and control the risk brought by shield tunnelling.The gap parameter is regarded as an effective tool to estimate the ground loss of tunnel... The probability analysis of ground deformation is becoming a trend to estimate and control the risk brought by shield tunnelling.The gap parameter is regarded as an effective tool to estimate the ground loss of tunnelling in soft soil.More specifically,x,which is a gap parameter component defined as the over(or insufficient)excavation due to the change in the posture of the shield machine,may contribute more to the uncertainty of the ground loss.However,the existing uncertainty characterization methods for x have several limitations and cannot explain the uncertain correlations between the relevant parameters.Along these lines,to better characterize the uncertainty of x,the multivariate probability distribution was developed in this work and a dynamic prediction was proposed for it.To attain this goal,1523 rings of the field data coming from the shield tunnel between Longqing Road and Baiyun Road in Kunming Metro Line 5 were utilized and 44 parameters including the construction,stratigraphic,and posture parameters were collected to form the database.According to the variance filter method,the mutual information method,and the value of the correlation coefficients,the original 44 parameters were reduced to 10 main parameters,which were unit weight,the stoke of the jacks(A,B,C,and D groups),the pressure of the pushing jacks(A,C groups),the chamber pressure,the rotation speed,and the total force.The multivariate probability distribution was constructed based on the Johnson system of distributions.Moreover,the distribution was satisfactorily verified in explaining the pairwise correlation between x and other parameters through 2 million simulation cases.At last,the distribution was used as a prior distribution to update the marginal distribution of x with any group of the relevant parameters known.The performance of the dynamic prediction was further validated by the field data of 3 shield tunnel cases. 展开更多
关键词 Shield tunnel Ground loss Gap parameter Multivariate probability distribution Bayesian updating Dynamic prediction
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