The influence of curing temperature on the strength development of cement-stabilized mud has been well documented in terms of strength-increase rate and ultimate strength.However,the strength development model is not ...The influence of curing temperature on the strength development of cement-stabilized mud has been well documented in terms of strength-increase rate and ultimate strength.However,the strength development model is not mature for the extremely early stages.In addition,there is a lack of studies on quality control methods based on early-stage strength development.This paper presents a strength model for cement-stabilized mud to address these gaps,considering various curing temperatures and early-stage behaviors.In this study,a series of laboratory experiments was conducted on two types of muds treated with Portland blast furnace cement and ordinary Portland cement under four different temperatures.The results indicate that elevated temperatures expedite strength development and lead to higher long-term strength.The proposed model,which combines a three-step conversion process and a hyperbolic model at the reference temperature,enables accurate estimate of the strength development for cement-treated mud with any proportions cured under various temperatures.With this model,a practical early quality control method is introduced for applying cement-stabilized mud in field projects.The back-analysis parameters obtained from a 36-h investigation at temperature of 60C demonstrated a sufficient accuracy in predicting strength levels in practical applications.展开更多
Lignocellulose shows significantly potential in sustainable conversion to high-quality fuel and valueadded chemicals with the demands for realizing the rapid cycle of carbon resources and helping to reach carbon neutr...Lignocellulose shows significantly potential in sustainable conversion to high-quality fuel and valueadded chemicals with the demands for realizing the rapid cycle of carbon resources and helping to reach carbon neutrality in nature.Selective tailoring of α-O-4,β-O-4,etc.linkages in lignin has always been viewed as "death blow" for its depolymerization.Herein,novel sodium lignosulfonate(SL) modified Fe_(3)O_(4)/TiO_(2)(SL-Fe_(3)O_(4)/TiO_(2)) spherical particles have been developed and used as catalysts for selectively photocatalytic oxidative cleavage of organosolv lignin.As expected,80% selective conversion of lignin in C2-C4 esters has been achieved,while C-O bonds in lignin model compounds can be effectively cleaved.Other than normal hydroxyl radical-mediated photocatalytic depolymerization of lignin over TiO_(2)-based materials,in this contribution,mechanism studies indicate that photogenerated holes and superoxide anion radicals are main active species,which trigger the cleavage of α/β-O-4 bond,and the isotopelabeling study confirms the crucial factor of C_β-H dehydrogenation in cleavage of β-O-4 bonds.展开更多
This paper is concerned with the pressureless Euler equations with viscous and flux perturbations.The existence of Riemann solutions to the pressureless Euler equations with viscous and flux perturbations is obtained....This paper is concerned with the pressureless Euler equations with viscous and flux perturbations.The existence of Riemann solutions to the pressureless Euler equations with viscous and flux perturbations is obtained.We show the stability of the delta wave of the pressureless Euler equations to the perturbations;that is,the limit solution of the pressureless Euler equations with viscous and flux perturbations is the delta wave solution of the pressureless Euler equations as the viscous and flux perturbation simultaneously vanish in the case u_(-)> u_(+).展开更多
Laterality is a crucial physiological process intricately linked to the cilium-centrosome complex during embryo development.Defects in the process can result in severe organ mispositioning.Coiled-coil domain containin...Laterality is a crucial physiological process intricately linked to the cilium-centrosome complex during embryo development.Defects in the process can result in severe organ mispositioning.Coiled-coil domain containing 141(CCDC141)has been previously known as a centrosome-related gene,but its role in left-right(LR)asymmetry has not been characterized.In this study,we utilize the zebrafish model and human exome analysis to elucidate the function of ccdc141 in laterality defects.The knockdown of ccdc141 in zebrafish disrupts early LR signaling pathways,cilia function,and Kupffer's vesicle formation.Unlike ccdc141-knockdown embryos exhibiting aberrant LR patterns,ccdc141-null mutants show no apparent abnormality,suggesting a genetic compensation response effect.In parallel,we observe a marked reduction inα-tubulin acetylation levels in the ccdc141 crispants.The treatment with histone deacetylase(HDAC)inhibitors,particularly the HDAC6 inhibitor,rescues the ccdc141 crispant phenotypes.Furthermore,exome analysis of 70 patients with laterality defects reveals an increased burden of CCDC141 mutations,with in-vivo studies verifying the pathogenicity of the patient mutation CCDC141-R123G.Our findings highlight the critical role of ccdc141 in ciliogenesis and demonstrate that CCDC141 mutations lead to abnormal LR patterns,identifying it as a candidate gene for laterality defects.展开更多
Ether-based electrolytes with excellent reductive stability are compatible with sodium(Na)metal an-odes,which enables stable cycling for Na metal batteries even in an anode-free configuration.However,the practical app...Ether-based electrolytes with excellent reductive stability are compatible with sodium(Na)metal an-odes,which enables stable cycling for Na metal batteries even in an anode-free configuration.However,the practical applications of anode-free sodium batteries(AFSBs)with a high theoretical energy density are restricted by the low-rate capability and limited cycle life.Here we demonstrate that the mechanical properties of the separators,which have been overlooked in previous studies,can significantly affect the cycling stability of AFSBs due to the intrinsic softness of Na and the large volume variation of AFSBs during Na plating/stripping.By using various separators including polypropylene(PP),polyethylene(PE),PP/PE/PP tri-layer,and aluminum oxide-coated separators,we find that the balanced elastic moduli of the separator along the machine direction and transverse direction are crucial for enabling highly effi-cient Na plating and unlocking the 4 C fast-charging capability of the AFSBs at practical conditions including a high cathode active mass loading(13.5 mg/cm^(2)),lean electrolyte addition(8.8 mL/cm^(2)),and no pre-sodiation process.This study provides an important separator design principle for the develop-ment of high-rate and long-cycle-life AFSBs.展开更多
Poly(vinylidene fluoride)(PVDF)-based polymer electrolytes(PEs)with good electrochemical performance and processability as well as low-cost advantage,have great potential applications in solid-state lithium(Li)metal b...Poly(vinylidene fluoride)(PVDF)-based polymer electrolytes(PEs)with good electrochemical performance and processability as well as low-cost advantage,have great potential applications in solid-state lithium(Li)metal batteries(SSLMBs).PVDF-based PEs are generally produced by employing a solution-casting approach with N,N-dimethylformamide(DMF)as the solvent,accompanied by the formation of[DMF-Li^(+)]complex,which facilitates the Li-ion transport.However,the residual DMF can react continuously with lithium(Li)metal,thereby deteriorating the interface layer in the middle of the PVDF-based PEs and Li anodes.Herein,we introduce propylene carbonate(PC)into the PVDF-based PEs to regulate the solvation structure and stabilize the interface layer between the PEs and Li anodes.PC accelerates the dissociation of lithium oxalyldifluoroborate(LiODFB).Consequently,“lithium propylene dicarbonate(LPDC)‒B-O”oligomer forms as the interfacial layer with high tenacity,homogeneity,and densification,which improves the interfacial contact and suppresses the continuous reaction between the residual DMF and Li anode.We further demonstrate that the PVDF-based PE prepared with DMF-PC mix-solvents shows improved room-temperature ionic conductivity(1.18×10^(-3) S/cm),enhanced stability against electrodes,and superior cycling performance in LiCoO_(2)-based SSLMBs(maintaining 84% of the initial discharge capacity after 300 cycles).展开更多
The ORF9b protein,derived from the nucleocapsid’s open-reading frame in both SARS-CoV and SARS-CoV-2,serves as an accessory protein crucial for viral immune evasion by inhibiting the innate immune response.Despite it...The ORF9b protein,derived from the nucleocapsid’s open-reading frame in both SARS-CoV and SARS-CoV-2,serves as an accessory protein crucial for viral immune evasion by inhibiting the innate immune response.Despite its significance,the precise regulatory mechanisms underlying its function remain elusive.In the present study,we unveil that the ORF9b protein of SARS-CoV-2,including emerging mutant strains like Delta and Omicron,can undergo ubiquitination at the K67 site and subsequent degradation via the proteasome pathway,despite certain mutations present among these strains.Moreover,our investigation further uncovers the pivotal role of the translocase of the outer mitochondrial membrane 70(TOM70)as a substrate receptor,bridging ORF9b with heat shock protein 90 alpha(HSP90α)and Cullin 5(CUL5)to form a complex.Within this complex,CUL5 triggers the ubiquitination and degradation of ORF9b,acting as a host antiviral factor,while HSP90αfunctions to stabilize it.Notably,treatment with HSP90 inhibitors such as GA or 17-AAG accelerates the degradation of ORF9b,leading to a pronounced inhibition of SARS-CoV-2 replication.Single-cell sequencing data revealed an up-regulation of HSP90αin lung epithelial cells from COVID-19 patients,suggesting a potential mechanism by which SARS-CoV-2 may exploit HSP90αto evade the host immunity.Our study identifies the CUL5-TOM70-HSP90αcomplex as a critical regulator of ORF9b protein stability,shedding light on the intricate host–virus immune response dynamics and offering promising avenues for drug development against SARS-CoV-2 in clinical settings.展开更多
Global climate changes,such as extreme weather,sea levels rise,and biodiversity decline,have destructive impacts on the global agrofood system,in terms of crop yield,agrofood quality and consumer safety.Those stressed...Global climate changes,such as extreme weather,sea levels rise,and biodiversity decline,have destructive impacts on the global agrofood system,in terms of crop yield,agrofood quality and consumer safety.Those stressed conditions and environmental pollution for crop and agrofood prompt us to take immediate action to develop a whole-new-era agrofood system from the perspective of sustainability[1].展开更多
Bulk-type all-solid-state batteries(ASSBs)using sulfide solid electrolyte are considered as a promising alternative to commercial lithium-ion batteries owing to their high energy density and safety.However,cell energy...Bulk-type all-solid-state batteries(ASSBs)using sulfide solid electrolyte are considered as a promising alternative to commercial lithium-ion batteries owing to their high energy density and safety.However,cell energy density is often comparatively low due to use of a thick solid electrolyte separator and a lithium alloy as anode.For achieving high-performance ASSBs,creating a thin free-standing electrolyte with high-conductivity and good cycling stability against lithium anode is essential.In this work,we present Li_(6)PS_(5)Cl/poly(vinylidene difluoride)(LPSCl/PVDF)composite electrolytes prepared by a slurry method.The influence of the PVDF content on the microstructure,morphology,ionic conductivity and activation energy of the LPSCl/PVDF electrolytes is systematically investigated.Free-standing LPSCl/PVDF membranes with a thickness of 100-120 mm and a high ionic conductivity of about 1·10^(-3) S cm^(-1) at 25℃ are obtained.After adding PVDF to the LPSCl electrolyte,the cycling stability of the LPSCl electrolyte against lithium metal improves significantly.Therefore,LPSCl/PVDF composite electrolytes are promising candidates to be used in ASSBs.展开更多
The probability analysis of ground deformation is becoming a trend to estimate and control the risk brought by shield tunnelling.The gap parameter is regarded as an effective tool to estimate the ground loss of tunnel...The probability analysis of ground deformation is becoming a trend to estimate and control the risk brought by shield tunnelling.The gap parameter is regarded as an effective tool to estimate the ground loss of tunnelling in soft soil.More specifically,x,which is a gap parameter component defined as the over(or insufficient)excavation due to the change in the posture of the shield machine,may contribute more to the uncertainty of the ground loss.However,the existing uncertainty characterization methods for x have several limitations and cannot explain the uncertain correlations between the relevant parameters.Along these lines,to better characterize the uncertainty of x,the multivariate probability distribution was developed in this work and a dynamic prediction was proposed for it.To attain this goal,1523 rings of the field data coming from the shield tunnel between Longqing Road and Baiyun Road in Kunming Metro Line 5 were utilized and 44 parameters including the construction,stratigraphic,and posture parameters were collected to form the database.According to the variance filter method,the mutual information method,and the value of the correlation coefficients,the original 44 parameters were reduced to 10 main parameters,which were unit weight,the stoke of the jacks(A,B,C,and D groups),the pressure of the pushing jacks(A,C groups),the chamber pressure,the rotation speed,and the total force.The multivariate probability distribution was constructed based on the Johnson system of distributions.Moreover,the distribution was satisfactorily verified in explaining the pairwise correlation between x and other parameters through 2 million simulation cases.At last,the distribution was used as a prior distribution to update the marginal distribution of x with any group of the relevant parameters known.The performance of the dynamic prediction was further validated by the field data of 3 shield tunnel cases.展开更多
基金supported by funding from the National Natural Science Foundation of China (Grant Nos.51978303 and 52208367)the Fundamental Research Funds for the Central Universities (Grant No.2042023kfyq03).
文摘The influence of curing temperature on the strength development of cement-stabilized mud has been well documented in terms of strength-increase rate and ultimate strength.However,the strength development model is not mature for the extremely early stages.In addition,there is a lack of studies on quality control methods based on early-stage strength development.This paper presents a strength model for cement-stabilized mud to address these gaps,considering various curing temperatures and early-stage behaviors.In this study,a series of laboratory experiments was conducted on two types of muds treated with Portland blast furnace cement and ordinary Portland cement under four different temperatures.The results indicate that elevated temperatures expedite strength development and lead to higher long-term strength.The proposed model,which combines a three-step conversion process and a hyperbolic model at the reference temperature,enables accurate estimate of the strength development for cement-treated mud with any proportions cured under various temperatures.With this model,a practical early quality control method is introduced for applying cement-stabilized mud in field projects.The back-analysis parameters obtained from a 36-h investigation at temperature of 60C demonstrated a sufficient accuracy in predicting strength levels in practical applications.
基金the financial support of the Natural Science Foundation of China (21736003, 22178130 and 22005106)the Natural Science Foundation of Guangdong Province, China (2020A0505100008)the Science and Technology Program of Guangzhou (202206010024)。
文摘Lignocellulose shows significantly potential in sustainable conversion to high-quality fuel and valueadded chemicals with the demands for realizing the rapid cycle of carbon resources and helping to reach carbon neutrality in nature.Selective tailoring of α-O-4,β-O-4,etc.linkages in lignin has always been viewed as "death blow" for its depolymerization.Herein,novel sodium lignosulfonate(SL) modified Fe_(3)O_(4)/TiO_(2)(SL-Fe_(3)O_(4)/TiO_(2)) spherical particles have been developed and used as catalysts for selectively photocatalytic oxidative cleavage of organosolv lignin.As expected,80% selective conversion of lignin in C2-C4 esters has been achieved,while C-O bonds in lignin model compounds can be effectively cleaved.Other than normal hydroxyl radical-mediated photocatalytic depolymerization of lignin over TiO_(2)-based materials,in this contribution,mechanism studies indicate that photogenerated holes and superoxide anion radicals are main active species,which trigger the cleavage of α/β-O-4 bond,and the isotopelabeling study confirms the crucial factor of C_β-H dehydrogenation in cleavage of β-O-4 bonds.
文摘This paper is concerned with the pressureless Euler equations with viscous and flux perturbations.The existence of Riemann solutions to the pressureless Euler equations with viscous and flux perturbations is obtained.We show the stability of the delta wave of the pressureless Euler equations to the perturbations;that is,the limit solution of the pressureless Euler equations with viscous and flux perturbations is the delta wave solution of the pressureless Euler equations as the viscous and flux perturbation simultaneously vanish in the case u_(-)> u_(+).
基金supported by the National Natural Science Foundation of China(81970264).
文摘Laterality is a crucial physiological process intricately linked to the cilium-centrosome complex during embryo development.Defects in the process can result in severe organ mispositioning.Coiled-coil domain containing 141(CCDC141)has been previously known as a centrosome-related gene,but its role in left-right(LR)asymmetry has not been characterized.In this study,we utilize the zebrafish model and human exome analysis to elucidate the function of ccdc141 in laterality defects.The knockdown of ccdc141 in zebrafish disrupts early LR signaling pathways,cilia function,and Kupffer's vesicle formation.Unlike ccdc141-knockdown embryos exhibiting aberrant LR patterns,ccdc141-null mutants show no apparent abnormality,suggesting a genetic compensation response effect.In parallel,we observe a marked reduction inα-tubulin acetylation levels in the ccdc141 crispants.The treatment with histone deacetylase(HDAC)inhibitors,particularly the HDAC6 inhibitor,rescues the ccdc141 crispant phenotypes.Furthermore,exome analysis of 70 patients with laterality defects reveals an increased burden of CCDC141 mutations,with in-vivo studies verifying the pathogenicity of the patient mutation CCDC141-R123G.Our findings highlight the critical role of ccdc141 in ciliogenesis and demonstrate that CCDC141 mutations lead to abnormal LR patterns,identifying it as a candidate gene for laterality defects.
基金supported by the Basic Science Center Project of the National Natural Science Foundation of China(No.52388201)National Natural Science Foundation of China(Nos.U21A2080 and 92263206)+3 种基金National Key Research and Development Program of China(No.2022YFB2404403)Beijing Natural Science Foundation(No.L223008)Jiangyin-Tsinghua Innovation Lead Action Special Project(No.2022JYTH0108)Tsinghua-Toyota Joint Research Fund.
文摘Ether-based electrolytes with excellent reductive stability are compatible with sodium(Na)metal an-odes,which enables stable cycling for Na metal batteries even in an anode-free configuration.However,the practical applications of anode-free sodium batteries(AFSBs)with a high theoretical energy density are restricted by the low-rate capability and limited cycle life.Here we demonstrate that the mechanical properties of the separators,which have been overlooked in previous studies,can significantly affect the cycling stability of AFSBs due to the intrinsic softness of Na and the large volume variation of AFSBs during Na plating/stripping.By using various separators including polypropylene(PP),polyethylene(PE),PP/PE/PP tri-layer,and aluminum oxide-coated separators,we find that the balanced elastic moduli of the separator along the machine direction and transverse direction are crucial for enabling highly effi-cient Na plating and unlocking the 4 C fast-charging capability of the AFSBs at practical conditions including a high cathode active mass loading(13.5 mg/cm^(2)),lean electrolyte addition(8.8 mL/cm^(2)),and no pre-sodiation process.This study provides an important separator design principle for the develop-ment of high-rate and long-cycle-life AFSBs.
基金This work was financially supported by the Basic Science Center Program of the National Natural Science Foundation of China(Grant No.52388201).
文摘Poly(vinylidene fluoride)(PVDF)-based polymer electrolytes(PEs)with good electrochemical performance and processability as well as low-cost advantage,have great potential applications in solid-state lithium(Li)metal batteries(SSLMBs).PVDF-based PEs are generally produced by employing a solution-casting approach with N,N-dimethylformamide(DMF)as the solvent,accompanied by the formation of[DMF-Li^(+)]complex,which facilitates the Li-ion transport.However,the residual DMF can react continuously with lithium(Li)metal,thereby deteriorating the interface layer in the middle of the PVDF-based PEs and Li anodes.Herein,we introduce propylene carbonate(PC)into the PVDF-based PEs to regulate the solvation structure and stabilize the interface layer between the PEs and Li anodes.PC accelerates the dissociation of lithium oxalyldifluoroborate(LiODFB).Consequently,“lithium propylene dicarbonate(LPDC)‒B-O”oligomer forms as the interfacial layer with high tenacity,homogeneity,and densification,which improves the interfacial contact and suppresses the continuous reaction between the residual DMF and Li anode.We further demonstrate that the PVDF-based PE prepared with DMF-PC mix-solvents shows improved room-temperature ionic conductivity(1.18×10^(-3) S/cm),enhanced stability against electrodes,and superior cycling performance in LiCoO_(2)-based SSLMBs(maintaining 84% of the initial discharge capacity after 300 cycles).
基金supported by the National Key Research and Development Program of China(2021YFC2300103)the National Natural Science Foundation of China(U21A20384 and 82072293)+1 种基金the Natural Science Foundation of Hunan Province,China(2022JJ30692)the China Postdoctoral Science Foundation(2023M731520).
文摘The ORF9b protein,derived from the nucleocapsid’s open-reading frame in both SARS-CoV and SARS-CoV-2,serves as an accessory protein crucial for viral immune evasion by inhibiting the innate immune response.Despite its significance,the precise regulatory mechanisms underlying its function remain elusive.In the present study,we unveil that the ORF9b protein of SARS-CoV-2,including emerging mutant strains like Delta and Omicron,can undergo ubiquitination at the K67 site and subsequent degradation via the proteasome pathway,despite certain mutations present among these strains.Moreover,our investigation further uncovers the pivotal role of the translocase of the outer mitochondrial membrane 70(TOM70)as a substrate receptor,bridging ORF9b with heat shock protein 90 alpha(HSP90α)and Cullin 5(CUL5)to form a complex.Within this complex,CUL5 triggers the ubiquitination and degradation of ORF9b,acting as a host antiviral factor,while HSP90αfunctions to stabilize it.Notably,treatment with HSP90 inhibitors such as GA or 17-AAG accelerates the degradation of ORF9b,leading to a pronounced inhibition of SARS-CoV-2 replication.Single-cell sequencing data revealed an up-regulation of HSP90αin lung epithelial cells from COVID-19 patients,suggesting a potential mechanism by which SARS-CoV-2 may exploit HSP90αto evade the host immunity.Our study identifies the CUL5-TOM70-HSP90αcomplex as a critical regulator of ORF9b protein stability,shedding light on the intricate host–virus immune response dynamics and offering promising avenues for drug development against SARS-CoV-2 in clinical settings.
基金supported by the National Key Research and Development Program of China(2018YFE0127000)the National Natural Science Foundation of China(21675127 and 31972150)+3 种基金Shaanxi Provincial Science and Technology Innovation Team(2023-CX-TD-55)the Key Industries Innovation Chain Project of Shaanxi Province(2019ZDLSF07-08)the Natural Science Foundation Project in Guangdong Province(2020A1515010778)Qinghai Provincial Key Laboratory of Qinghai-Tibet Plateau Biological Resource(2020-ZJ-T05).
文摘Global climate changes,such as extreme weather,sea levels rise,and biodiversity decline,have destructive impacts on the global agrofood system,in terms of crop yield,agrofood quality and consumer safety.Those stressed conditions and environmental pollution for crop and agrofood prompt us to take immediate action to develop a whole-new-era agrofood system from the perspective of sustainability[1].
基金supported by the Basic Science Center Program of NSFC under Grant No.51788104NSFC projects under Grant Nos.51532002,51572141,and 51625202financial support within the project 03XP0177A funded by BMBF with the cluster of competence FESTBATT.
文摘Bulk-type all-solid-state batteries(ASSBs)using sulfide solid electrolyte are considered as a promising alternative to commercial lithium-ion batteries owing to their high energy density and safety.However,cell energy density is often comparatively low due to use of a thick solid electrolyte separator and a lithium alloy as anode.For achieving high-performance ASSBs,creating a thin free-standing electrolyte with high-conductivity and good cycling stability against lithium anode is essential.In this work,we present Li_(6)PS_(5)Cl/poly(vinylidene difluoride)(LPSCl/PVDF)composite electrolytes prepared by a slurry method.The influence of the PVDF content on the microstructure,morphology,ionic conductivity and activation energy of the LPSCl/PVDF electrolytes is systematically investigated.Free-standing LPSCl/PVDF membranes with a thickness of 100-120 mm and a high ionic conductivity of about 1·10^(-3) S cm^(-1) at 25℃ are obtained.After adding PVDF to the LPSCl electrolyte,the cycling stability of the LPSCl electrolyte against lithium metal improves significantly.Therefore,LPSCl/PVDF composite electrolytes are promising candidates to be used in ASSBs.
基金support provided by the National Natural Science Foundation of China(Grant Nos.52078236 and 52122806)Guangzhou Metro Group Co.,Ltd(JT204-100111-23001)Chongqing Urban Investment Infrastructure Construction Co(Grant No.CQCT-JS-SC-GC-2022-0081).
文摘The probability analysis of ground deformation is becoming a trend to estimate and control the risk brought by shield tunnelling.The gap parameter is regarded as an effective tool to estimate the ground loss of tunnelling in soft soil.More specifically,x,which is a gap parameter component defined as the over(or insufficient)excavation due to the change in the posture of the shield machine,may contribute more to the uncertainty of the ground loss.However,the existing uncertainty characterization methods for x have several limitations and cannot explain the uncertain correlations between the relevant parameters.Along these lines,to better characterize the uncertainty of x,the multivariate probability distribution was developed in this work and a dynamic prediction was proposed for it.To attain this goal,1523 rings of the field data coming from the shield tunnel between Longqing Road and Baiyun Road in Kunming Metro Line 5 were utilized and 44 parameters including the construction,stratigraphic,and posture parameters were collected to form the database.According to the variance filter method,the mutual information method,and the value of the correlation coefficients,the original 44 parameters were reduced to 10 main parameters,which were unit weight,the stoke of the jacks(A,B,C,and D groups),the pressure of the pushing jacks(A,C groups),the chamber pressure,the rotation speed,and the total force.The multivariate probability distribution was constructed based on the Johnson system of distributions.Moreover,the distribution was satisfactorily verified in explaining the pairwise correlation between x and other parameters through 2 million simulation cases.At last,the distribution was used as a prior distribution to update the marginal distribution of x with any group of the relevant parameters known.The performance of the dynamic prediction was further validated by the field data of 3 shield tunnel cases.