Impaired neurodevelopmental outcome represents a major morbidity for survivors of infant heart surgery for congenital heart defects. Previous studies in these neonates have reported preoperative microcephaly, perivent...Impaired neurodevelopmental outcome represents a major morbidity for survivors of infant heart surgery for congenital heart defects. Previous studies in these neonates have reported preoperative microcephaly, periventricular leukomalacia, and other findings. The hypothesis of this study is that preoperative cerebral blood flow is substantially diminished and might relate to preoperative neurolog ic conditions. Preoperative brain magnetic resonance imaging was performed. Cere bral blood flow measurements in infants with congenital heart defects were obtai ned by using a novel noninvasive magnetic resonance imaging technique, pulsed ar terial spin-label perfusion magnetic resonance imaging. Cerebral blood flow was measured before the operation under standard ventilation and repeated after inc reased carbon dioxide. A total of 25 term infants were studied. The average age at the time of the operation was 4.4 ±.4.6 days. Congenital heart defects varie d widely. Microcephaly occurred in 24%(6/25). Baseline cerebral blood flow was 19.7±9.2 mL·100 g-1·min-1(8.0-42.2 mL·100 g -1·min-1). Five patients h ad cerebral blood flow measurements of less than 10 mL·100 g-1·min -1. Mean hypercarbic cerebral blood flow increased to 40.1±20.3 mL·100 g-1·min-1 (11 .4-94.0 mL·100 g-1·min-1,P < . 001). Pairwise analyses found that low hemog lobin levels were associated with higher baseline cerebral blood flow values (P= . 04). Periventricular leukomalacia occurred in 28%(7/25) and was associated wi th decreased baseline cerebral blood flow values (P=. 05) and a smaller change i n cerebral blood flow with hypercarbia (P=. 003). Structural brain abnormalities are common in these neonates before surgical intervention. Preoperative cerebra l blood flow for this cohort was low and drastically reduced in some patients. L ow cerebral blood flow values were associated with periventricular leukomalacia. Carbon dioxide reactivity was preserved but might be compromised by some aspect s of the cardiac anatomy. The full spectrum of cerebral blood flow measurements with this technique in congenital heart defects and their long-term significanc e require continued investigation. Copyright.展开更多
文摘Impaired neurodevelopmental outcome represents a major morbidity for survivors of infant heart surgery for congenital heart defects. Previous studies in these neonates have reported preoperative microcephaly, periventricular leukomalacia, and other findings. The hypothesis of this study is that preoperative cerebral blood flow is substantially diminished and might relate to preoperative neurolog ic conditions. Preoperative brain magnetic resonance imaging was performed. Cere bral blood flow measurements in infants with congenital heart defects were obtai ned by using a novel noninvasive magnetic resonance imaging technique, pulsed ar terial spin-label perfusion magnetic resonance imaging. Cerebral blood flow was measured before the operation under standard ventilation and repeated after inc reased carbon dioxide. A total of 25 term infants were studied. The average age at the time of the operation was 4.4 ±.4.6 days. Congenital heart defects varie d widely. Microcephaly occurred in 24%(6/25). Baseline cerebral blood flow was 19.7±9.2 mL·100 g-1·min-1(8.0-42.2 mL·100 g -1·min-1). Five patients h ad cerebral blood flow measurements of less than 10 mL·100 g-1·min -1. Mean hypercarbic cerebral blood flow increased to 40.1±20.3 mL·100 g-1·min-1 (11 .4-94.0 mL·100 g-1·min-1,P < . 001). Pairwise analyses found that low hemog lobin levels were associated with higher baseline cerebral blood flow values (P= . 04). Periventricular leukomalacia occurred in 28%(7/25) and was associated wi th decreased baseline cerebral blood flow values (P=. 05) and a smaller change i n cerebral blood flow with hypercarbia (P=. 003). Structural brain abnormalities are common in these neonates before surgical intervention. Preoperative cerebra l blood flow for this cohort was low and drastically reduced in some patients. L ow cerebral blood flow values were associated with periventricular leukomalacia. Carbon dioxide reactivity was preserved but might be compromised by some aspect s of the cardiac anatomy. The full spectrum of cerebral blood flow measurements with this technique in congenital heart defects and their long-term significanc e require continued investigation. Copyright.
