Background:Studies that clearly define the possible association of childhood vitiligo with autoimmune and/or endocrine diseases are lacking. Objective:To ex amine the presence of autoimmune disorders, in particular of...Background:Studies that clearly define the possible association of childhood vitiligo with autoimmune and/or endocrine diseases are lacking. Objective:To ex amine the presence of autoimmune disorders, in particular of thyroid disease, in paediatric patients with vitiligo and investigate the utility of such screening in these patients. Methods:One hundred and twenty-one paediatric patients (40 males, 81 females) with vitiligo were grouped in segmental and non-segmental v itiligo. All patients were screened for thyroid disease. Results:13 out of 121 patients had different degrees of thyroid parameter alterations. These patients were all affected by the non-segmental type while none of those with the segmen tal form presented thyroid alterations. Conclusion:In paediatric patients with non-segmental vitiligo, a significant incidence of thyroid dysfunction was foun d. Since vitiligo usually appears before the development of the thyroid disease, it may be useful to screen thyroid autoantibodies in all paediatric patients wi th non-segmental vitiligo who present symptoms related to thyroid disease.展开更多
文摘Background:Studies that clearly define the possible association of childhood vitiligo with autoimmune and/or endocrine diseases are lacking. Objective:To ex amine the presence of autoimmune disorders, in particular of thyroid disease, in paediatric patients with vitiligo and investigate the utility of such screening in these patients. Methods:One hundred and twenty-one paediatric patients (40 males, 81 females) with vitiligo were grouped in segmental and non-segmental v itiligo. All patients were screened for thyroid disease. Results:13 out of 121 patients had different degrees of thyroid parameter alterations. These patients were all affected by the non-segmental type while none of those with the segmen tal form presented thyroid alterations. Conclusion:In paediatric patients with non-segmental vitiligo, a significant incidence of thyroid dysfunction was foun d. Since vitiligo usually appears before the development of the thyroid disease, it may be useful to screen thyroid autoantibodies in all paediatric patients wi th non-segmental vitiligo who present symptoms related to thyroid disease.
