Objective:To evaluate the antihyperglycemic activity of Tecomaria aipensis(T.capensis) Thunb. (Bignoniaceae) methanolic leaves extract(TCLE) using blood glucose level in normal fasted rats, glucose tolerance test and ...Objective:To evaluate the antihyperglycemic activity of Tecomaria aipensis(T.capensis) Thunb. (Bignoniaceae) methanolic leaves extract(TCLE) using blood glucose level in normal fasted rats, glucose tolerance test and alloxan induced hyperglycemia models.Methods:TCLE(100,300, 1 000 and 2 000 mg/kg body wt.) was given to rats orally to observe acute toxicity,and observed for 14 d.TCLE 200 and 400 mg/kg,and glibenclamide 0.6 mg/kg were given orally in all models. Results:Results demonstrated that the no mortality was reported even after 14 d.This indicates that the methanol extract is safe up to a single dose of 2 000 mg/kg body weight.TCLE(200 and 400 mg/kg p.o.) exhibited remarkable blood glucose lowering effect in blood glucose level in normal fasted rats,glucose tolerance and alloxan induced hyperglycemia model.Cholesterol and triglyceride also decreased in alloxan induced hyperglycemia model.Condosions:The results of this study exhibites that methanol extract of T.capensis possesses antihypergycemic activity and it may prove to be effective for the treatment of hyperglycemia.展开更多
Objective:To evaluate the ann-nociceptive activity of Tecomaria capensls(T.capensis) leaves extract(TCLE) using different models in rats by acetic acid induced writhing test,(b) tail-flick test(c) tail-clip test.Metho...Objective:To evaluate the ann-nociceptive activity of Tecomaria capensls(T.capensis) leaves extract(TCLE) using different models in rats by acetic acid induced writhing test,(b) tail-flick test(c) tail-clip test.Methods:TCLE(100,300,1000 and 2000 mg/kg body wt.) was given to rats orally to observe acute toxicity for 14 d.Then test drug TCLE were given at dose of 100,200 and 500 mg/kg p.o.and standard drug aspirin were given at a dose of 100 mg/kg p.o.Results:No mortality was reported even after 14 d.This indicates that the methanol extract is safe up to a single dose of 2 000 mg/kg body weight TCLE(100,200 and 500 mg/kg p.o.) significandy inhibited abdominal constrictions(writhing) induced by acetic acid and increased the latency period in the tail flick and tail clip test.TCLE at the dose of 500 mg/kg showed significant anti-nociceptive activity compared to standard aspirin.Discussions:The results of this study show that methanol extract of T.capensis possesses anti-nociceptive activity which may be mediated by the central and peripheral mechanisms.展开更多
The aim of the present study was to evaluate the potential wound healing activity of Tecomaria capensis leaves extract (TCLE) using different models in rats. (a) Excision wound model, (b) Incision wound model and (c) ...The aim of the present study was to evaluate the potential wound healing activity of Tecomaria capensis leaves extract (TCLE) using different models in rats. (a) Excision wound model, (b) Incision wound model and (c) Dead space wound model. TCLE (100, 300, 1 000 and 2 000 mg·kg-1) was given to rats to observe acute toxicity. No toxicity was found in animals till 14 days. TCLE 5% and 10% ointment were applied topically in excision wound model and incision wound model. TCLE 200 and 400 mg·kg-1 were given orally in dead space wound model. It improved healing in excision wound model, increased breaking strength of tissue in incision wound model, and increased granuloma breaking strength and hydroxyproline content in dead space wound model. These results showed that TCLE presents significant wound healing activity.展开更多
文摘Objective:To evaluate the antihyperglycemic activity of Tecomaria aipensis(T.capensis) Thunb. (Bignoniaceae) methanolic leaves extract(TCLE) using blood glucose level in normal fasted rats, glucose tolerance test and alloxan induced hyperglycemia models.Methods:TCLE(100,300, 1 000 and 2 000 mg/kg body wt.) was given to rats orally to observe acute toxicity,and observed for 14 d.TCLE 200 and 400 mg/kg,and glibenclamide 0.6 mg/kg were given orally in all models. Results:Results demonstrated that the no mortality was reported even after 14 d.This indicates that the methanol extract is safe up to a single dose of 2 000 mg/kg body weight.TCLE(200 and 400 mg/kg p.o.) exhibited remarkable blood glucose lowering effect in blood glucose level in normal fasted rats,glucose tolerance and alloxan induced hyperglycemia model.Cholesterol and triglyceride also decreased in alloxan induced hyperglycemia model.Condosions:The results of this study exhibites that methanol extract of T.capensis possesses antihypergycemic activity and it may prove to be effective for the treatment of hyperglycemia.
基金supported by the management and faculty of Jaipur National University,Jaipur,Rajasthan,India
文摘Objective:To evaluate the ann-nociceptive activity of Tecomaria capensls(T.capensis) leaves extract(TCLE) using different models in rats by acetic acid induced writhing test,(b) tail-flick test(c) tail-clip test.Methods:TCLE(100,300,1000 and 2000 mg/kg body wt.) was given to rats orally to observe acute toxicity for 14 d.Then test drug TCLE were given at dose of 100,200 and 500 mg/kg p.o.and standard drug aspirin were given at a dose of 100 mg/kg p.o.Results:No mortality was reported even after 14 d.This indicates that the methanol extract is safe up to a single dose of 2 000 mg/kg body weight TCLE(100,200 and 500 mg/kg p.o.) significandy inhibited abdominal constrictions(writhing) induced by acetic acid and increased the latency period in the tail flick and tail clip test.TCLE at the dose of 500 mg/kg showed significant anti-nociceptive activity compared to standard aspirin.Discussions:The results of this study show that methanol extract of T.capensis possesses anti-nociceptive activity which may be mediated by the central and peripheral mechanisms.
文摘The aim of the present study was to evaluate the potential wound healing activity of Tecomaria capensis leaves extract (TCLE) using different models in rats. (a) Excision wound model, (b) Incision wound model and (c) Dead space wound model. TCLE (100, 300, 1 000 and 2 000 mg·kg-1) was given to rats to observe acute toxicity. No toxicity was found in animals till 14 days. TCLE 5% and 10% ointment were applied topically in excision wound model and incision wound model. TCLE 200 and 400 mg·kg-1 were given orally in dead space wound model. It improved healing in excision wound model, increased breaking strength of tissue in incision wound model, and increased granuloma breaking strength and hydroxyproline content in dead space wound model. These results showed that TCLE presents significant wound healing activity.
