In this paper we propose an optimal design of ultra-wideband (4 ~ 20 GHz) microwave absorbers consisting of two resistive meta-surface layers of different square patch arrays. Gradient Descent and Genetic Algorithm nu...In this paper we propose an optimal design of ultra-wideband (4 ~ 20 GHz) microwave absorbers consisting of two resistive meta-surface layers of different square patch arrays. Gradient Descent and Genetic Algorithm numerical methods are employed to optimize all the parameters through equivalent transmission line circuit model. The circuit parameters are then implemented by a multilayer including two resistive meta-surfaces of square patch structures. Two types of such absorbing structures, with the total thicknesses close to that of the known theoretical limit, are designed and their performance are verified by full wave electromagnetic simulation.展开更多
Mesenchymal stem cells(MSCs)transplantation is a promising strategy for osteoporosis treatment.However,limited sources and poor tissue-homing efficiency limit their clinical capabilities.In this study,we isolated a ki...Mesenchymal stem cells(MSCs)transplantation is a promising strategy for osteoporosis treatment.However,limited sources and poor tissue-homing efficiency limit their clinical capabilities.In this study,we isolated a kind of MSCs from women’s menstrual blood(MenSCs)noninvasively and established a novel MSCs bone marrow-targeted delivery system by utilizing waterin-oil-in-water droplet microfluidics.MenSCs were encapsulated withinβ-cyclodextrin-functionalized alginate microcapsules loaded with zoledronates,which has a high affinity for bone.With this delivery system,MenSCs could be preferentially delivered to the bone marrow tissues via intravenous infusion,and restored bone mass by remodeling the bone marrow niche in situ in ovariectomized mouse models.Moreover,scRNA-seq analysis demonstrated that those MenSCs homed to the bone marrow recruited CD4^(+)FOXP3^(+)natural regulatory T(nT_(reg))cells by secreting CCL28.The recruited nTreg promoted CD8^(+)T cells to secret Wnt family member 10B(WNT10B),activating the Wnt signaling in osteoblasts and thus promoting bone formation in situ in the bone marrow.This study reveals a promising application of MenSCs in postmenopausal osteoporosis treatment and highlights the clinical value of MenSCs by encouraging women to reserve autologous MenSCs before menopause to prevent and alleviate postmenopausal osteoporosis.展开更多
文摘In this paper we propose an optimal design of ultra-wideband (4 ~ 20 GHz) microwave absorbers consisting of two resistive meta-surface layers of different square patch arrays. Gradient Descent and Genetic Algorithm numerical methods are employed to optimize all the parameters through equivalent transmission line circuit model. The circuit parameters are then implemented by a multilayer including two resistive meta-surfaces of square patch structures. Two types of such absorbing structures, with the total thicknesses close to that of the known theoretical limit, are designed and their performance are verified by full wave electromagnetic simulation.
基金supported by the National Key R&D Program of China(No.2022YFA1105603)the Fundamental Research Funds for the Central Universities(No.2022ZFJH003)+3 种基金National Science&Technology Major Project“Key New Drug Creation and Manufacturing Program”(No.2018ZX09201002-005)the National Natural Science Foundation of China(Nos.82200994 and 81900563)CAMS Innovation Fund for Medical Sciences(No.2019-I2M-5-045)Shanghai Post-doctoral Excellence Program(No.2022428).
文摘Mesenchymal stem cells(MSCs)transplantation is a promising strategy for osteoporosis treatment.However,limited sources and poor tissue-homing efficiency limit their clinical capabilities.In this study,we isolated a kind of MSCs from women’s menstrual blood(MenSCs)noninvasively and established a novel MSCs bone marrow-targeted delivery system by utilizing waterin-oil-in-water droplet microfluidics.MenSCs were encapsulated withinβ-cyclodextrin-functionalized alginate microcapsules loaded with zoledronates,which has a high affinity for bone.With this delivery system,MenSCs could be preferentially delivered to the bone marrow tissues via intravenous infusion,and restored bone mass by remodeling the bone marrow niche in situ in ovariectomized mouse models.Moreover,scRNA-seq analysis demonstrated that those MenSCs homed to the bone marrow recruited CD4^(+)FOXP3^(+)natural regulatory T(nT_(reg))cells by secreting CCL28.The recruited nTreg promoted CD8^(+)T cells to secret Wnt family member 10B(WNT10B),activating the Wnt signaling in osteoblasts and thus promoting bone formation in situ in the bone marrow.This study reveals a promising application of MenSCs in postmenopausal osteoporosis treatment and highlights the clinical value of MenSCs by encouraging women to reserve autologous MenSCs before menopause to prevent and alleviate postmenopausal osteoporosis.
