The oral cavity contains the second-largest microbiota in the human body.The cavity's anatomically and physiologically diverse niches facilitate a wide range of symbiotic bacteria living at distinct oral sites.Con...The oral cavity contains the second-largest microbiota in the human body.The cavity's anatomically and physiologically diverse niches facilitate a wide range of symbiotic bacteria living at distinct oral sites.Consequently,the oral microbiota exhibits site specificity,with diverse species,compositions,and structures influenced by specific aspects of their placement.Variations in oral microbiota structure caused by changes in these influencing factors can impact overall health and lead to the development of diseases-not only in the oral cavity but also in organs distal to the mouth-such as cancer,cardiovascular disease,and respiratory disease.Conversely,diseases can exacerbate the imbalance of the oral microbiota,creating a vicious cycle.Understanding the heterogeneity of both the oral microbiome and individual humans is important for investigating the causal links between the oral microbiome and diseases.Additionally,understanding the intricacies of the oral microbiome's com-position and regulatory factors will help identify the potential causes of related diseases and develop interventions to prevent and treat llnesses in this domain.Therefore,turning to the extant research in this field,we systematically review the relationship between oral microbiome dynamics and human diseases.展开更多
基金This work was supported financially by the National Key Research and Development Programe of China(grant No.2019YFA0906700 to T.D.)the National Natural Science Foundation of China(grant No.32270071 to T.D.).
文摘The oral cavity contains the second-largest microbiota in the human body.The cavity's anatomically and physiologically diverse niches facilitate a wide range of symbiotic bacteria living at distinct oral sites.Consequently,the oral microbiota exhibits site specificity,with diverse species,compositions,and structures influenced by specific aspects of their placement.Variations in oral microbiota structure caused by changes in these influencing factors can impact overall health and lead to the development of diseases-not only in the oral cavity but also in organs distal to the mouth-such as cancer,cardiovascular disease,and respiratory disease.Conversely,diseases can exacerbate the imbalance of the oral microbiota,creating a vicious cycle.Understanding the heterogeneity of both the oral microbiome and individual humans is important for investigating the causal links between the oral microbiome and diseases.Additionally,understanding the intricacies of the oral microbiome's com-position and regulatory factors will help identify the potential causes of related diseases and develop interventions to prevent and treat llnesses in this domain.Therefore,turning to the extant research in this field,we systematically review the relationship between oral microbiome dynamics and human diseases.
