Medicinal plants,since times immemorial,have been used in virtually all cultures for therapeutic purposes.Anagallis arvensis(L.)is a well-known medicinal plant traditionally utilized for a varied range of disorders in...Medicinal plants,since times immemorial,have been used in virtually all cultures for therapeutic purposes.Anagallis arvensis(L.)is a well-known medicinal plant traditionally utilized for a varied range of disorders including wound healing,lung problems,kidney stones,urinary tract infections,gout,and rheumatic conditions.This review is an attempt to summarize and comprehend the fragmented information until now published in the literature on the biochemical and toxicological perspective of A.arvensis.The literature was searched electronically from PubMed,EMBASE,Scopus,Science Direct,Ovid MEDLINE and Google Scholar.It was found that ethnomedical uses of A.arvensis plant and parts have been recorded throughout the world,where it has been used against a panoply of diseases.Phytochemical search has led to the identification of flavonoids,terpenoids,triterpenoid glycosides,phytosterols as main classes of secondary metabolites with a few other classes.A wide spectrum of in vivo and in vitro pharmacological activities have been reported from fresh plant material and its crude extracts and/or fractions.However there is currently a dearth of structure-activity studies of the isolated compounds and mechanistic studies from this species.The plant has also been reported for in vivo toxicity.It is clear from this review thatA.arvensis,though traditionally used by various cultures harbour a plethora of bioactive compounds exhibiting multifarious biological effects that could be exploited as biopharmaceuticals.Nonetheless,additional research work and structure-activity studies arekey prerequisite to transmute the empirical claims on the utilization of A.arvenisis in folklore medicines and a food plant into scientific shreds of evidence.展开更多
The current research work aimed at the phytochemical,biological,and in-silico properties of hydro-methanol extract and n-hexane fraction of Crateva adansonii aerial parts.Total bioactive content and UHPLC-MS analysis ...The current research work aimed at the phytochemical,biological,and in-silico properties of hydro-methanol extract and n-hexane fraction of Crateva adansonii aerial parts.Total bioactive content and UHPLC-MS analysis were used to determine the phytochemical composition.Regarding biological activities,antioxidant(DPPH,ABTS,FRAP,CUPRAC,phosphomolybdenum,and metal chelation)and enzyme inhibition(againstα-amylase,tyrosinase,acetylcholinesterase-AChE,and butyrylcholinesterase-BChE)activities were assessed.The hydro-methanol extract contained higher phenolic(28.09 mg GAE/g extract)and flavonoid(65.61 mg RE/g extract)contents,which might be correlated with the higher antioxidant potential of this extract.For the enzyme assays,the n-hexane fraction was most active against BChE andα-amylase,while the methanol extract presented higher inhibition values against AChE and tyrosinase enzymes.Likewise,different phytocompounds have been tentatively identified by UHPLC-MS of hydro-methanol extract;most of these belonged to phenolic and flavonoid classes.Furthermore,three important identified phytocompounds(isovitexin,robinetin 3-rutinoside,and luteolin 7-robinobioside),were selected for in-silico computational studies against the tyrosinase enzyme.The present investigation revealed that the studied extract/fraction of C.adansonii are likely sources of phytoconstituents identified through UHPLC-MS with considerable antioxidant and enzyme inhibitory properties.To conclude,the evaluated plant should be further investigated for the isolation of bioactive molecules which can be utilized in phytopharmaceuticals.展开更多
文摘Medicinal plants,since times immemorial,have been used in virtually all cultures for therapeutic purposes.Anagallis arvensis(L.)is a well-known medicinal plant traditionally utilized for a varied range of disorders including wound healing,lung problems,kidney stones,urinary tract infections,gout,and rheumatic conditions.This review is an attempt to summarize and comprehend the fragmented information until now published in the literature on the biochemical and toxicological perspective of A.arvensis.The literature was searched electronically from PubMed,EMBASE,Scopus,Science Direct,Ovid MEDLINE and Google Scholar.It was found that ethnomedical uses of A.arvensis plant and parts have been recorded throughout the world,where it has been used against a panoply of diseases.Phytochemical search has led to the identification of flavonoids,terpenoids,triterpenoid glycosides,phytosterols as main classes of secondary metabolites with a few other classes.A wide spectrum of in vivo and in vitro pharmacological activities have been reported from fresh plant material and its crude extracts and/or fractions.However there is currently a dearth of structure-activity studies of the isolated compounds and mechanistic studies from this species.The plant has also been reported for in vivo toxicity.It is clear from this review thatA.arvensis,though traditionally used by various cultures harbour a plethora of bioactive compounds exhibiting multifarious biological effects that could be exploited as biopharmaceuticals.Nonetheless,additional research work and structure-activity studies arekey prerequisite to transmute the empirical claims on the utilization of A.arvenisis in folklore medicines and a food plant into scientific shreds of evidence.
文摘The current research work aimed at the phytochemical,biological,and in-silico properties of hydro-methanol extract and n-hexane fraction of Crateva adansonii aerial parts.Total bioactive content and UHPLC-MS analysis were used to determine the phytochemical composition.Regarding biological activities,antioxidant(DPPH,ABTS,FRAP,CUPRAC,phosphomolybdenum,and metal chelation)and enzyme inhibition(againstα-amylase,tyrosinase,acetylcholinesterase-AChE,and butyrylcholinesterase-BChE)activities were assessed.The hydro-methanol extract contained higher phenolic(28.09 mg GAE/g extract)and flavonoid(65.61 mg RE/g extract)contents,which might be correlated with the higher antioxidant potential of this extract.For the enzyme assays,the n-hexane fraction was most active against BChE andα-amylase,while the methanol extract presented higher inhibition values against AChE and tyrosinase enzymes.Likewise,different phytocompounds have been tentatively identified by UHPLC-MS of hydro-methanol extract;most of these belonged to phenolic and flavonoid classes.Furthermore,three important identified phytocompounds(isovitexin,robinetin 3-rutinoside,and luteolin 7-robinobioside),were selected for in-silico computational studies against the tyrosinase enzyme.The present investigation revealed that the studied extract/fraction of C.adansonii are likely sources of phytoconstituents identified through UHPLC-MS with considerable antioxidant and enzyme inhibitory properties.To conclude,the evaluated plant should be further investigated for the isolation of bioactive molecules which can be utilized in phytopharmaceuticals.
