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Nicotine and its metabolite cotinine target MD2 and inhibit TLR4 signaling
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作者 Hongyuan Li Yinghua Peng +9 位作者 Cong Lin Xiaozheng Zhang Tianshu Zhang Yibo Wang Yuanpeng Li siru wu Hongshuang Wang Mark RHutchinson Linda RWatkins Xiaohui Wang 《The Innovation》 2021年第2期139-147,共9页
Nicotine is the principal alkaloid of tobacco often manufactured into cigarettes and belongs to a highly addictive class of drugs.Nicotine attenuates the neuroinflammation induced by microglial activation.However,the ... Nicotine is the principal alkaloid of tobacco often manufactured into cigarettes and belongs to a highly addictive class of drugs.Nicotine attenuates the neuroinflammation induced by microglial activation.However,the molecular target(s)underlying anti-inflammatory action of nicotine has not been fully understood.Considering the psychoactive substances morphine,cocaine,and methamphetamine act as xenobiotic-associated molecular patterns and can be specifically sensed by the innate immune receptor Toll-like receptor 4(TLR4),here we sought to delineate whether nicotine and/or its metabolite cotinine may be recognized by the innate immune system via myeloid differentiation protein 2(MD2). 展开更多
关键词 belongs ALKALOID system
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