Neuro-11:a new questionnaire for the assessment of somatic symptom disorder in general hospitals

Background Somatic symptom disorder(SSD)commonly presents in general hospital settings,posing challenges for healthcare professionals lacking specialised psychiatric training.The Neuro-11 Neurosis Scale(Neuro-11)offers promise in screening and evaluating psychosomatic symptoms,comprising 11 concise items across three dimensions:somatic symptoms,negative emotions and adverse events.Prior research has validated the scale’s reliability,validity and theoretical framework in somatoform disorders,indicating its potential as a valuable tool for SSD screening in general hospitals.Aims This study aimed to establish the reliability,validity and threshold of the Neuro-11 by comparing it with standard questionnaires commonly used in general hospitals for assessing SSD.Through this comparative analysis,we aimed to validate the effectiveness and precision of the Neuro-11,enhancing its utility in clinical settings.Methods Between November 2020 and December 2021,data were collected from 731 patients receiving outpatient and inpatient care at Shenzhen People’s Hospital in China for various physical discomforts.The patients completed multiple questionnaires,including the Neuro-11,Short Form 36 Health Survey,Patient Health Questionnaire 15 items,Hamilton Anxiety Scale and Hamilton Depression Scale.Psychiatry-trained clinicians conducted structured interviews and clinical examinations to establish a gold standard diagnosis of SSD.Results The Neuro-11 demonstrated strong content reliability and structural consistency,correlating significantly with internationally recognised and widely used questionnaires.Despite its brevity,the Neuro-11 exhibited significant correlations with other questionnaires.A test-retest analysis yielded a correlation coefficient of 1.00,Spearman-Brown coefficient of 0.64 and Cronbach’sαcoefficient of 0.72,indicating robust content reliability and internal consistency.Confirmatory factor analysis confirmed the validity of the three-dimensional structure(p<0.001,comparative fit index=0.94,Tucker-Lewis index=0.92,root mean square error of approximation=0.06,standardised root mean square residual=0.04).The threshold of the Neuro-11 is set at 10 points based on the maximum Youden’s index from the receiver operating characteristic curve analysis.In terms of diagnostic efficacy,the Neuro-11 has an area under the curve of 0.67.

Street Stall Economy in China in the COVID-19 Era:Dilemmas and the International Experience of Promoting the Normalization of Street Stall Economy

Compared with those major policies that need to be practiced over the years,the street stall economy is more like a special means after the epidemic,resulting in a“short and brilliant”heat.Nevertheless,the street stall economy revives is facing several dilemmas.This paper reveals the dilemma of the prosperity and development of the stall economy before and after the epidemic,followed by the international experience and enlightenment of promoting the normalization of street stall economy,ranging from street vendor’s legal status and road administrative promotion to street food safety and environmental protection.To sum up,employment is the foundation of people’s livelihood and the source of wealth,hence,stall economy plays an indispensable role to create a win-win working world and promote the formation of a sustainable economic.

Storage, form, and influencing factors of karst inorganic carbon in a carbonate area in China

Carbonate rock chemical weathering carbon sinks reduce the rate of increase of the atmospheric CO_(2) concentration and global warming. However, uncertainty still exists in the estimation results of carbonate rock chemical weathering carbon sink fluxes(CCSF), and the contributions of climate change and ecological restoration to the CCSF are not clear. To this end, we compiled published site data on ion concentrations in different watersheds in China and used a classical thermodynamic dissolution model to reassess the potential and spatial and temporal patterns of the CCSF in China from 1991 to 2020. We quantified the contributions of temperature(MAT), precipitation(MAP), evapotranspiration(ET), soil water(SM), and the normalized difference vegetation index(NDVI) to the CCSF. The results revealed that(1) China's CCSF was 22.76 t CO_(2)km^(-2)yr^(-1), which was higher than the global average(15.77 t CO_(2)km^(-2)yr^(-1)). The total carbonate rock chemical weathering carbon sink(CCS) was 4772.67×10^(4)t CO_(2), contributing 14.91% of the global CCS through a carbonate rock area of 252.98×10^(4)km^(-2).(2) China's CCSF decreased gradually from southeast to northwest, with values of 33.14, 12.93, and7.27 t CO_(2)km^(-2)yr^(-1)in the southern karst, Qinghai-Tibetan karst, and northern karst regions, respectively.(3) The overall CCSF in China exhibited an increasing trend from 1991 to 2020, with a rate of increase of 0.16 t CO_(2)km^(-2)yr^(-1).(4) The contributions of the MAP, MAT, ET, SM, and NDVI to the CCSF were 63.3%, 3.02%, 27.5%, 3.1%, and 3.05%, respectively. Among them, the increase in precipitation was the main contributor to the increase in the CCSF in China over the last 30 years, while the enhancement of ET offset part of the positive contribution of the increase in precipitation to the CCSF. In conclusion, the results of this study provide a systematic quantification of the magnitude, the patterns, and the influencing factors of CCS over a long time series in China. The results are of great significance and provide a reference for the diagnosis and gap analysis of the national and global carbon neutrality capacities.

中国喀斯特生态系统健康诊断的方法、进展与展望

中国是碳酸盐岩型喀斯特面积最大、分布最广的国家,在喀斯特地区居住着约2亿的人口,经济规模约占全国的10%.尤其是以贵州为中心的西南地区,位于长江和珠江的上游,经济欠发达,但却是国家的重要生态安全屏障.喀斯特地貌重要而特殊,科学诊断其生态系统的健康不仅对生态修复和实现可持续发展至关重要,更是制定应对方案的基本前提.尽管以往开展了大量的研究工作,但是依然缺乏系统性和整体性认识.本文结合前人研究,进一步将喀斯特地貌演化发育总结为6个阶段:成岩阶段、成陆阶段、成山阶段、成丛阶段、成林阶段和成原阶段.在此基础上,又从碳酸盐岩风化成土速率的计算、土壤水的诊断、水土流失的评价、石漠化解译与演变、生态系统服务的科学计量5个方面进行系统的总结和梳理.尽管不同时代、不同学者的不同研究方法,其结果有着非常大的差异.但是,综合考虑已有的研究结果及其使用方法的优点和不足,归纳发现:(1)碳酸盐岩化学风化很快(30~130 mm ka^(−1)),但由于其酸不溶物含量低(5%以内),导致其成土速率极其缓慢,一般在5~50 t km^(−2)a^(−1)之间.(2)土壤少且分布不连续,但是土壤含水量却比较高,在0.2~0.4 m^(3)m^(−3)之间,这可能与周边基岩的汇水效应相关,且未来呈干化趋势.(3)土壤侵蚀模数低,一般在2~200 t km^(−2)a^(−1)之间,但由于坡陡、降雨量大且与岩土突变接触,导致其侵蚀风险极大,并存在一定比例的地下漏失现象.(4)石漠化的演变可分为单变式、渐进式和返变式3种经典类型,但是通过决策树和人机交互的石漠化解译方法相对高效和精准.(5)喀斯特生态系统服务功能的评价模型要基于成土速率来进行修正水土保持功能和基于岩溶地质碳汇修正气候调节功能.当前诊断喀斯特生态系统健康的指标、方法和模型亟须改进和创新,要充分体现喀斯特地区的特殊性和模型方法的匹配性,提高监测数据的时空分辨率,特别是亟须建立喀斯特社会-生态系统耦合模型,准确刻画出喀斯特生态系统对气候变化和人类活动的响应过程,提升诊断模型的准确度和可预测性.总之,本文系统总结了诊断中国喀斯特生态系统健康与可持续性的方法和取得的重大进展,并进一步从“岩-土-水-石-生”的角度提出了未来的研究方向和突破重点,以期为维护喀斯特地区的生态安全和可持续发展提供科技支撑.

A carbon-neutrality-capactiy index for evaluating carbon sink contributions

The accurate determination of the carbon-neutrality capacity(CNC)of a region is crucial for developing policies related to emissions and climate change.However,a systematic diagnostic method for determining the CNC that considers the rock chemical weathering carbon sink(RCS)is lacking.Moreover,it is challenging but indispensable to establish a fast and practical index model to determine the CNC.Here,we selected Guizhou as the study area,used the methods for different types of carbon sinks,and constructed a CNC index(CNCI)model.We found that:(1)the carbonate rock chemical weathering carbon sink flux was 30.3 t CO_(2)km^(-2)yr^(-1).Guizhou accounted for 1.8%of the land area and contributed 5.4%of the carbonate chemical weathering carbon sink;(2)the silicate rock chemical weathering carbon sink and its flux were 1.44×10^(3)t CO_(2)and 2.43 t CO_(2)km^(-2)yr^(-1),respectively;(3)the vegetation-soil ecosystem carbon sink and its flux were 1.37×10^(8)t CO_(2)and 831.70 t CO_(2)km^(-2)yr^(-1),respectively;(4)the carbon emissions(CEs)were 280 Tg CO_(2),about 2.8%of the total for China;and(5)the total carbon sinks in Guizhou were 160 Tg CO_(2),with a CNCI of 57%,which is 4.8 times of China and 2.1 times of the world.In summary,we conducted a systematic diagnosis of the CNC considering the RCS and established a CNCI model.The results of this study have a strong implication and significance for national and global CNC determination and gap analysis.

Domain Wall Evolution in Hf_(0.5)Zr_(0.5)O_(2)Ferroelectrics under Field-Cycling Behavior

HfO_(2)-based ferroelectrics have evoked considerable interest owing to the complementary metal-oxide semiconductor compatibility and robust ferroelectricity down to a few unit cells.However,the unique wake-up effect of HfO_(2)-based ferroelectric films severely restricts the improvement of their performance.In particular,the domain structure is an important characteristic of ferroelectric materials,which still has not been well understood in HfO_(2)-based ferroelectrics.In this work,a Hf_(0.5)Zr_(0.5)O_(2) ferroelectric thin film is grown on a typical Si substrate buffered with TiN electrode.The 90°domains of the Pca21 ferroelectric phase with head-to-tail and tail-to-tail structures can be observed by Cs-corrected scanning transmission electron microscope under their pristine condition.After waking up,the 180°domain is displayed in the ferroelectric phase.The remarkable differences in domain walls for 90°and 180°domains are characterized by qualitatively mapping the polarization distributions at the atomic scale.The domain wall changes from the[101]of the Hf_(0.5)Zr_(0.5)O_(2) film to the[001]of the Hf_(0.5)Zr_(0.5)O_(2) film.This result provides fundamental information for understanding the domain structure of HfO_(2)-based ferroelectrics.

Splicing dysregulation in cancer: from mechanistic understanding to a new class of therapeutic targets

RNA splicing dysregulation is widespread in cancer. Accumulating evidence demonstrates that splicing defects resulting from splicing dysregulation play critical roles in cancer pathogenesis and can serve as new biomarkers and therapeutic targets for cancer intervention. These findings have greatly deepened the mechanistic understandings of the regulation of alternative splicing in cancer cells, leading to rapidly growing interests in targeting cancer-related splicing defects as new therapies. Here we summarize the current research progress on splicing dysregulation in cancer and highlight the strategies available or under development for targeting RNA splicing defects in cancer.

Observational study of the physical and chemical characteristics of the winter radiation fog in the tropical rainforest in Xishuangbanna, China

We conducted a three-month field experiment focusing on the physical and chemical characteristics of fog in a tropical rainforest in Xishuangbanna,Southwest China,in the winter of 2019.In general,the fog would form at midnight and persist because of the increased long-wave radiative cooling combined with the high relative humidity,gentle breeze,and a relatively low aerosol number concentration in the forest;the fog would dissipate before noon due to the increasing turbulence near the surface.This diurnal cycle is typical for radiation fog.The microphysical fog properties included a relatively low number concentration of the fog droplet,large droplet size,high liquid water content,narrow droplet number-size distribution,and high supersaturation.The chemical properties showed that the fog water was slightly alkaline with low electrical conductivity,whereas the highest proportions of anions and cations therein were Cl^(−)and Ca^(2+),respectively;the chemical components were enriched in small fog droplets.In addition,we indirectly calculated the fog supersaturation according to theκ-Köhler theory.We found that condensation broadens the droplet number-size distribution at relatively low supersaturation,which is positively correlated with the fog-droplet number concentration and negatively correlated with the droplet mean-volume diameter;this affects the key microphysical processes of fog.