Theranostic nanodrugs combining magnetic resonance imaging(MRI)and cancer therapy have attracted extensive interest in cancer diagnosis and treatment.Herein,a manganese(Mn)-doped mesoporous polydopamine(Mn-MPDA)nanodr...Theranostic nanodrugs combining magnetic resonance imaging(MRI)and cancer therapy have attracted extensive interest in cancer diagnosis and treatment.Herein,a manganese(Mn)-doped mesoporous polydopamine(Mn-MPDA)nanodrug incorporating the nitric oxide(NO)prodrug BNN6 and immune agonist R848 was developed.The nanodrug responded to the H^(+)and glutathione being enriched in tumor microenvironment to release R848 and Mn^(2+).The abundant Mn^(2+)produced through a Fenton-like reaction enabled a highly sensitive T1-T2 dual-mode MRI for monitoring the tumor accumulation process of the nanodrug,based on which an MRI-guided laser irradiation was achieved to trigger the NO gas therapy.Meanwhile,R848 induced the re-polarization of tumor-promoting M2-like macrophage to a tumoricidal M1 phenotype.Consequently,a potent synergistic antitumor effect was realized in mice bearing subcutaneous 4T1 breast cancer,which manifested the great promise of this multifunctional nanoplatform in cancer treatment.展开更多
Rational design of robust non-noble electrocatalysts with numerous oxygen vacancies and highly reactive activity for oxygen reduction reaction(ORR)towards Zn-air batteries is extremely paramount yet challenging.Herein...Rational design of robust non-noble electrocatalysts with numerous oxygen vacancies and highly reactive activity for oxygen reduction reaction(ORR)towards Zn-air batteries is extremely paramount yet challenging.Herein,a novel CeO_(2)C_(2)nanoparticles self-embedded in Fe,N co-doped carbon nanofibers(CeO_(2)C_(2)@Fe-N-C)heterostructure catalyst has been prepared by the in-site dual template assisted electrospinning technique and subsequent high temperature pyrolysis strategy.Thanks to the CeO_(2)C_(2)with oxygen-enriched vacancies and versatile Fe-N-C with rich reactive species and high conductivity,CeO_(2)C_(2)@Fe-N-C catalyst exhibits outstanding catalytic performance in the ORR process,and shows excellent methanol tolerance and cycle stability.In addition,CeO_(2)C_(2)@Fe-N-C delivers a nearly four-electron transfer process in the process of oxygen reduction catalysis,providing a fast-electrochemical kinetic rate,which makes it an efficient air cathode for the Zn-air battery.Importantly,the Zn-air battery fabricated with CeO_(2)C_(2)@Fe-N-C cathode achieves superior performance including large open-circuit voltage(1.5 V)and high specific capacity(780 mAh·g–1 at 10 mA·cm–2)together with superior reversibility and cycling stability,outperforming commercial Pt/C catalyst.The present work introduces a new strategy to design and develop highly active non-noble catalysts and highlights the synergy from heterostructure in oxygen electrocatalysis for advanced Zn-air batteries.展开更多
基金supported by the National Natural Science Foundation of China(Nos.51933011 and 31971296)the Key Areas Research and Development Program of Guangzhou(No.202007020006)+3 种基金Guangdong Basic and Applied Basic Research Foundation(No.2020A1515010523)Guangzhou Science and Technology Bureau(No.202102010181)Guangdong Provincial Key Laboratory of Sensing Technology and Biomedical Instrument(Sun Yat-sen University,No.2020B1212060077)approved by the Institutional Animal Care and Use Committee at Sun Yat-sen University(SYSU-IACUC-2021-000225).
文摘Theranostic nanodrugs combining magnetic resonance imaging(MRI)and cancer therapy have attracted extensive interest in cancer diagnosis and treatment.Herein,a manganese(Mn)-doped mesoporous polydopamine(Mn-MPDA)nanodrug incorporating the nitric oxide(NO)prodrug BNN6 and immune agonist R848 was developed.The nanodrug responded to the H^(+)and glutathione being enriched in tumor microenvironment to release R848 and Mn^(2+).The abundant Mn^(2+)produced through a Fenton-like reaction enabled a highly sensitive T1-T2 dual-mode MRI for monitoring the tumor accumulation process of the nanodrug,based on which an MRI-guided laser irradiation was achieved to trigger the NO gas therapy.Meanwhile,R848 induced the re-polarization of tumor-promoting M2-like macrophage to a tumoricidal M1 phenotype.Consequently,a potent synergistic antitumor effect was realized in mice bearing subcutaneous 4T1 breast cancer,which manifested the great promise of this multifunctional nanoplatform in cancer treatment.
基金The State Administration of Traditional Chinese Medicine Young Qihuang Scholars Support Project(Approval Document No.:National Traditional Chinese Medicine[2020]No.7)Key Research and Development Program of Shanxi Province(International Science and Technology Cooperation)Major Regional Innovation Cooperation Project(Grant No.201803D421006)+1 种基金Shanxi University of Traditional Chinese Medicine,Postgraduate Innovation and Entrepreneurship Project(Grant No.2021CX046)Shanxi University of Traditional Chinese Medicine,Science and Technology Innovation Ability Cultivation Project(Grant No.2020PY-YC-35,2021PY-QN-10)。
基金supported by the National Natural Science Foundation of China(Nos.42167068,51863019)Outstanding Youth Fund of Gansu Province(20JR5RA539)Gansu Province Higher Education Industry Support Plan Project(2021CYZC-09).
文摘Rational design of robust non-noble electrocatalysts with numerous oxygen vacancies and highly reactive activity for oxygen reduction reaction(ORR)towards Zn-air batteries is extremely paramount yet challenging.Herein,a novel CeO_(2)C_(2)nanoparticles self-embedded in Fe,N co-doped carbon nanofibers(CeO_(2)C_(2)@Fe-N-C)heterostructure catalyst has been prepared by the in-site dual template assisted electrospinning technique and subsequent high temperature pyrolysis strategy.Thanks to the CeO_(2)C_(2)with oxygen-enriched vacancies and versatile Fe-N-C with rich reactive species and high conductivity,CeO_(2)C_(2)@Fe-N-C catalyst exhibits outstanding catalytic performance in the ORR process,and shows excellent methanol tolerance and cycle stability.In addition,CeO_(2)C_(2)@Fe-N-C delivers a nearly four-electron transfer process in the process of oxygen reduction catalysis,providing a fast-electrochemical kinetic rate,which makes it an efficient air cathode for the Zn-air battery.Importantly,the Zn-air battery fabricated with CeO_(2)C_(2)@Fe-N-C cathode achieves superior performance including large open-circuit voltage(1.5 V)and high specific capacity(780 mAh·g–1 at 10 mA·cm–2)together with superior reversibility and cycling stability,outperforming commercial Pt/C catalyst.The present work introduces a new strategy to design and develop highly active non-noble catalysts and highlights the synergy from heterostructure in oxygen electrocatalysis for advanced Zn-air batteries.
