To the Editor:Insomnia affects 30%-50%of adults globally,leading to diminished quality of life and increased risks of developing physically and mentally demanding disorders.[1]Previous research,primarily in Western po...To the Editor:Insomnia affects 30%-50%of adults globally,leading to diminished quality of life and increased risks of developing physically and mentally demanding disorders.[1]Previous research,primarily in Western populations,reported the association between insomnia and poor diet quality,characterized by higher energy intake,lower vegetable consumption,and a preference for fatty foods,risk factors contributing to major chronic conditions.[2]This association,however,remains under-explored in Asian populations.展开更多
In addition to offering morphological visualizations via capture of the spatial distributions of optical absorption,photoacoustic imaging technology can reveal abundant physical information about biological particles,...In addition to offering morphological visualizations via capture of the spatial distributions of optical absorption,photoacoustic imaging technology can reveal abundant physical information about biological particles,including their orientation,density,and viscoelasticity,through analysis of the pressure transients in the spectral domain.However,the low-amplitude wideband photoacoustic signals of intrinsic microscopic optically-absorbing objects under the action of confined photoacoustic excitation power continue to hinder simultaneous photoacoustic structural imaging and spectroscopic analysis of the nonfluorescent chromophores in living biological tissues because of the inadequate responses to photoacoustic impulses observed in most photoacoustic imaging setups that include piezoelectric transducers.Building upon a recently-developed optical evanescent wave sensor that can respond to ultrasound with high sensitivity over a broad frequency range,we propose in vivo spatial-spectral photoacoustic microscopy for recovery of structural imaging in three dimensions and characterization of anatomical features in the acoustic frequency domain.Label-free photoacoustic images of a living zebrafish are acquired in which spectroscopically-resolved differentiation of the microarchitecture is accessed,along with isometric micrometer-scale volumetric visualizations.The proposed imaging technology could potentially provide more comprehensive evaluations of the physiopathological status of living small animals.展开更多
Over the past few years, the rapid development of tactile sensing technology has contributed significantly to the realization of intuitional touch control and intelligent human-machine interaction. Apart from physical...Over the past few years, the rapid development of tactile sensing technology has contributed significantly to the realization of intuitional touch control and intelligent human-machine interaction. Apart from physical touch or pressure sensing, proximity sensing as a complementary function can extend the detection mode of common single functional tactile sensors. In this work, we present a transparent, matrix-structure dual functional capacitive sensor which integrates the capability of proximity and pressure sensing in one device, and the excellent spatial resolution offered by the isolated response of capacitive pixels enables us to realize precise location identification of approaching objects and loaded pressure with fast response, high stability and high reversibility.展开更多
Because of the fingerprint-like specificity of its characteristic spectrogram, Raman spectral imaging has been applied widely in various research areas. Using a combination of structured illumination with the surface-...Because of the fingerprint-like specificity of its characteristic spectrogram, Raman spectral imaging has been applied widely in various research areas. Using a combination of structured illumination with the surface- enhanced Raman scattering （SERS） technique, wide-field Raman imaging is developed with a significant improve- ment in spatial resolution. As a result of the relatively narrow Raman characteristic peaks, optically encoded SERS nanoparticles can be used to perform multiplexed imaging. The results show excellent superresolution wide-fidd multiplexed imaging performance. The developed technique has extraordinary potential for applications in biological imaging and other related fields.展开更多
Tip-enhanced Raman scattering(TERS)spectroscopy is a nondestructive and label-free molecular detection approach that provides high sensitivity and nanoscale spatial resolution.Therefore,it has been used in a wide arra...Tip-enhanced Raman scattering(TERS)spectroscopy is a nondestructive and label-free molecular detection approach that provides high sensitivity and nanoscale spatial resolution.Therefore,it has been used in a wide array of applications.We demonstrate a gap-plasmon hybridization facilitated by a bottom-illuminated TERS configuration.The gap-plasmon hybridization effect is first performed with the finite-difference time-domain method to optimize the parameters,and experiments are then conducted to calibrate the performance.The results demonstrate an enhancement factor of 1157 and a spatial resolution of 13.5 nm.The proposed configuration shows great potential in related surface imaging applications in various fields of research.展开更多
基金supported by grants from the Startup Grant at Fudan University(Nos.JIF201036Y and JIF201040Y).
文摘To the Editor:Insomnia affects 30%-50%of adults globally,leading to diminished quality of life and increased risks of developing physically and mentally demanding disorders.[1]Previous research,primarily in Western populations,reported the association between insomnia and poor diet quality,characterized by higher energy intake,lower vegetable consumption,and a preference for fatty foods,risk factors contributing to major chronic conditions.[2]This association,however,remains under-explored in Asian populations.
基金This work was supported in part by the Guangdong Major Project of Basic and Applied Basic Research[grant number 2020B0301030009]the National Natural Science Foundation of China(NSFC)[grant numbers 62175159,62175157,12174204,62071306]+3 种基金the Natural Science Foundation of Guangdong Province,Guangdong,China[2023A1515012888]the Science and Technology Innovation Commission of Shenzhen[grant numbers KQTD20170330110444030,JCYJ20200109113808048,RCJC20210609103232046,JCYJ20200109113601723,JSGG20210802154203011,JSGG20210420091805014,JCYJ20220818101417039]Key Research Project of Zhejiang Lab:K2022MG0AC05China Postdoctoral Science Foundation:2022M722174.
文摘In addition to offering morphological visualizations via capture of the spatial distributions of optical absorption,photoacoustic imaging technology can reveal abundant physical information about biological particles,including their orientation,density,and viscoelasticity,through analysis of the pressure transients in the spectral domain.However,the low-amplitude wideband photoacoustic signals of intrinsic microscopic optically-absorbing objects under the action of confined photoacoustic excitation power continue to hinder simultaneous photoacoustic structural imaging and spectroscopic analysis of the nonfluorescent chromophores in living biological tissues because of the inadequate responses to photoacoustic impulses observed in most photoacoustic imaging setups that include piezoelectric transducers.Building upon a recently-developed optical evanescent wave sensor that can respond to ultrasound with high sensitivity over a broad frequency range,we propose in vivo spatial-spectral photoacoustic microscopy for recovery of structural imaging in three dimensions and characterization of anatomical features in the acoustic frequency domain.Label-free photoacoustic images of a living zebrafish are acquired in which spectroscopically-resolved differentiation of the microarchitecture is accessed,along with isometric micrometer-scale volumetric visualizations.The proposed imaging technology could potentially provide more comprehensive evaluations of the physiopathological status of living small animals.
基金This work was supported by the National Natural Science Foundation of China （No. 61204001）, and the Fundamental Research Funds for the Central Universities of China （No. 2014QN013）. We also thank the Center for Nanoscale Characterization ＆ Devices （CNCD）, WNLO of HUST for the use of facilities in support of this work.
文摘Over the past few years, the rapid development of tactile sensing technology has contributed significantly to the realization of intuitional touch control and intelligent human-machine interaction. Apart from physical touch or pressure sensing, proximity sensing as a complementary function can extend the detection mode of common single functional tactile sensors. In this work, we present a transparent, matrix-structure dual functional capacitive sensor which integrates the capability of proximity and pressure sensing in one device, and the excellent spatial resolution offered by the isolated response of capacitive pixels enables us to realize precise location identification of approaching objects and loaded pressure with fast response, high stability and high reversibility.
基金National Natural Science Foundation of China(NSFC)(61490712,61427819,91750205,61605117)National Key Basic Research Program of China(973)(2015CB352004)+4 种基金Leading Talents of Guangdong Province Program(00201505)Natural Science Foundation of Guangdong Province(2016A030312010,2016A030310063,2017A030313351)National Key Research and Development Program of China(2016YFC0102401)Science and Technology Innovation Commission of Shenzhen(KQTD2017033011044403,KQTD2015071016560101,ZDSYS201703031605029)Excellent Young Teacher Program of Guangdong Province(YQ2014151)
文摘Because of the fingerprint-like specificity of its characteristic spectrogram, Raman spectral imaging has been applied widely in various research areas. Using a combination of structured illumination with the surface- enhanced Raman scattering （SERS） technique, wide-field Raman imaging is developed with a significant improve- ment in spatial resolution. As a result of the relatively narrow Raman characteristic peaks, optically encoded SERS nanoparticles can be used to perform multiplexed imaging. The results show excellent superresolution wide-fidd multiplexed imaging performance. The developed technique has extraordinary potential for applications in biological imaging and other related fields.
基金National Natural Science Foundation of China(61427819,91750205,11774256,61805154,61605117)Natural Science Foundation of Guangdong Province(2016A030312010)+1 种基金Leading Talents Program of Guangdong Province(00201505)Science and Technology Innovation Commission of Shenzhen(KQTD2017033011044403,ZDSYS201703031605029,JCYJ20180305125209538,JCYJ2017818144338999)。
文摘Tip-enhanced Raman scattering(TERS)spectroscopy is a nondestructive and label-free molecular detection approach that provides high sensitivity and nanoscale spatial resolution.Therefore,it has been used in a wide array of applications.We demonstrate a gap-plasmon hybridization facilitated by a bottom-illuminated TERS configuration.The gap-plasmon hybridization effect is first performed with the finite-difference time-domain method to optimize the parameters,and experiments are then conducted to calibrate the performance.The results demonstrate an enhancement factor of 1157 and a spatial resolution of 13.5 nm.The proposed configuration shows great potential in related surface imaging applications in various fields of research.
