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PD-1/PD-L1抑制剂在非小细胞肺癌中的临床研究进展 被引量:15
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作者 吴思璇 胡春宏 +2 位作者 吴芳 吴元强 刘平 《中国肺癌杂志》 CAS CSCD 北大核心 2019年第7期440-448,共9页
非小细胞肺癌(non-small cell lung cancer, NSCLC)是肺癌最常见的病理类型。近年来,免疫治疗迅速发展,免疫检查点抑制剂尤其是程序性死亡因子-1(programmed death-1, PD-1)/程序性死亡因子配体-1(programmed death-ligand 1, PD-L1)抑... 非小细胞肺癌(non-small cell lung cancer, NSCLC)是肺癌最常见的病理类型。近年来,免疫治疗迅速发展,免疫检查点抑制剂尤其是程序性死亡因子-1(programmed death-1, PD-1)/程序性死亡因子配体-1(programmed death-ligand 1, PD-L1)抑制剂已在NSCLC的治疗中取得突破性进展,改变了NSCLC治疗的格局。以PD-1/PD-L1为靶点的免疫检查点抑制剂无论在晚期NSCLC的一线和二线治疗,局部晚期NSCLC的辅助治疗,还是早期NSCLC的新辅助治疗中均为患者带来获益,在NSCLC的综合治疗中显示出重要地位。本文针对以PD-1/PD-L1为靶点的免疫检查点抑制剂在NSCLC中的临床研究进展展开综述。 展开更多
关键词 肺肿瘤 肿瘤免疫治疗 PD-1/PD-L1 免疫检查点抑制剂
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Zircon classification from cathodoluminescence images using deep learning
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作者 Dongyu Zheng sixuan wu +4 位作者 Chao Ma Lu Xiang Li Hou Anqing Chen Mingcai Hou 《Geoscience Frontiers》 SCIE CAS CSCD 2022年第6期111-121,共11页
Zircon is a widely-used heavy mineral in geochronological and geochemical research because it can extract important information to understand the history and genesis of rocks. Zircon has various types,and an accurate ... Zircon is a widely-used heavy mineral in geochronological and geochemical research because it can extract important information to understand the history and genesis of rocks. Zircon has various types,and an accurate examination of zircon type is a prerequisite procedure before further analysis.Cathodoluminescence(CL) imaging is one of the most reliable ways to classify zircons. However, current CL image examination is conducted by manual work, which is time-consuming, bias-prone, and requires expertise. An automated and bias-free method for zircon classification is absent but necessary. To this end, deep convolutional neural networks(DCNNs) and transfer learning are applied in this study to classify the common types of zircons, i.e., igneous, metamorphic, and hydrothermal zircons. An atlas with over 4000 CL images of these three types of zircons is created, and three DCNNs are trained using these images. The results of this study indicate that the DCNNs can distinguish hydrothermal zircons from other zircons, as indicated by the highest accuracy of 100%. Although similar textures in igneous and metamorphic zircons pose great challenges for zircon classification, the DCNNs successfully classify 95% igneous and 92% metamorphic zircons. This study demonstrates the high accuracy of DCNNs in zircon classification and presents the great potentiality of deep learning techniques in numerous geoscientific disciplines. 展开更多
关键词 ZIRCON Cathodoluminescence image Deep learning Transfer learning
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