Photodynamic therapy(PDT)agents may accumulate in skin and cause severe skin cytotoxicity.We report a pro-guest-based supramolecular strategy to selectively activate PDT in the reactive oxygen specie(ROS)overexpressed...Photodynamic therapy(PDT)agents may accumulate in skin and cause severe skin cytotoxicity.We report a pro-guest-based supramolecular strategy to selectively activate PDT in the reactive oxygen specie(ROS)overexpressed microenvironment,which is often existing in tumor and inflammatory tissues.PDT agents methylene blue(MB)and basic blue 17(BB17)are used as model drugs.When encapsulated by acyclic cucurbit[n]uril(CB[n]),the efficacy of PDT agents is significantly inhibited.By contrast,in the presence of ROS(H_(2)O_(2))and pro-guest,PDT agents are displaced and reactivated to show a dramatically enhanced PDT efficacy in cells.展开更多
We report supramolecular AND logic gates based on host-guest complexation between acid-labile acyclic cucurbit[n]uril(CB[n]) molecular container and Na Cl O-responsive dye. Supramolecular AND logic gate is turned on d...We report supramolecular AND logic gates based on host-guest complexation between acid-labile acyclic cucurbit[n]uril(CB[n]) molecular container and Na Cl O-responsive dye. Supramolecular AND logic gate is turned on due to acid-triggered degradation of molecular container and the release of the dye, followed by Na Cl O-induced fluorescence “switch on” effect of the dye. The reason for AND molecular logic gate is discovered to be the combination of oxidation inhibition and fluorescence “switch off” effect. Supramolecular AND logic gate is confirmed to be operational in live MCF-7 and He La cancer cells.展开更多
Glutathione thiol-reactive pillar[6]arene(TWP6)is designed and synthesized as the first example of reducing agent-reactive host molecule.TWP6 shows high affinity binding towards suitable anti-tumor drugs and guests.Do...Glutathione thiol-reactive pillar[6]arene(TWP6)is designed and synthesized as the first example of reducing agent-reactive host molecule.TWP6 shows high affinity binding towards suitable anti-tumor drugs and guests.Doxorubicin-based acid-labile prodrugs and TWP6 are used to construct supramolecular vesicles,which are also loaded with camptothecin.The supramolecular vesicles loaded with two drugs demonstrate glutathione-and acid-responsive drug release as well as sequential release to both stimuli types.Supramolecular vesicles show combination therapeutic effect towards tumor cells in vitro.展开更多
基金National Natural Science Foundation of China(No.21921003)for financial support。
文摘Photodynamic therapy(PDT)agents may accumulate in skin and cause severe skin cytotoxicity.We report a pro-guest-based supramolecular strategy to selectively activate PDT in the reactive oxygen specie(ROS)overexpressed microenvironment,which is often existing in tumor and inflammatory tissues.PDT agents methylene blue(MB)and basic blue 17(BB17)are used as model drugs.When encapsulated by acyclic cucurbit[n]uril(CB[n]),the efficacy of PDT agents is significantly inhibited.By contrast,in the presence of ROS(H_(2)O_(2))and pro-guest,PDT agents are displaced and reactivated to show a dramatically enhanced PDT efficacy in cells.
基金National Natural Science Foundation of China (Nos.21921003 and 21672042) for financial support。
文摘We report supramolecular AND logic gates based on host-guest complexation between acid-labile acyclic cucurbit[n]uril(CB[n]) molecular container and Na Cl O-responsive dye. Supramolecular AND logic gate is turned on due to acid-triggered degradation of molecular container and the release of the dye, followed by Na Cl O-induced fluorescence “switch on” effect of the dye. The reason for AND molecular logic gate is discovered to be the combination of oxidation inhibition and fluorescence “switch off” effect. Supramolecular AND logic gate is confirmed to be operational in live MCF-7 and He La cancer cells.
基金National Natural Science Foundation of China(Nos.21921003 and 21672042)Zhengzhou University for financial support。
文摘Glutathione thiol-reactive pillar[6]arene(TWP6)is designed and synthesized as the first example of reducing agent-reactive host molecule.TWP6 shows high affinity binding towards suitable anti-tumor drugs and guests.Doxorubicin-based acid-labile prodrugs and TWP6 are used to construct supramolecular vesicles,which are also loaded with camptothecin.The supramolecular vesicles loaded with two drugs demonstrate glutathione-and acid-responsive drug release as well as sequential release to both stimuli types.Supramolecular vesicles show combination therapeutic effect towards tumor cells in vitro.
