Knee osteoarthritis:A review of animal models and intervention of traditional Chinese medicine

Background:Knee osteoarthritis(KOA)characterized by degeneration of knee cartilage and subsequent bone hyperplasia is a prevalent joint condition primarily affecting aging adults.The pathophysiology of KOA remains poorly understood,as it involves complex mechanisms that result in the same outcome.Consequently,researchers are interested in studying KOA and require appropriate animal models for basic research.Chinese herbal compounds,which consist of multiple herbs with diverse pharmacological properties,possess characteristics such as multicomponent,multipathway,and multitarget effects.The potential benefits in the treatment of KOA continue to attract attention.Purpose:This study aims to provide a comprehensive overview of the advantages,limitations,and specific considerations in selecting different species and methods for KOA animal models.This will help researchers make informed decisions when choosing an animal model.Methods:Online academic databases(e.g.,PubMed,Google Scholar,Web of Science,and CNKI)were searched using the search terms“knee osteoarthritis,”“animal models,”“traditional Chinese medicine,”and their combinations,primarily including KOA studies published from 2010 to 2023.Results:Based on literature retrieval,this review provides a comprehensive overview of the methods of establishing KOA animal models;introduces the current status of advantages and disadvantages of various animal models,including mice,rats,rabbits,dogs,and sheep/goats;and presents the current status of methods used to establish KOA animal models.Conclusion:This study provides a review of the animal models used in recent KOA research,discusses the common modeling methods,and emphasizes the role of traditional Chinese medicine compounds in the treatment of KOA.

Establishment and Application of a Radiation Dose Rate Model for Nuclear Medicine Examinees

Introduction:Traditional methods for determining radiation dose in nuclear medicine include the Monte Carlo method,the discrete ordinate method,and the point kernel integration method.This study presents a new mathematical model for predicting the radiation dose rate in the vicinity of nuclear medicine patients.Methods:A new algorithm was created by combining the physical model of“cylinder superposition”of the human body with integral analysis to assess the radiation dose rate in the vicinity of nuclear medicine patients.Results:The model accurately predicted radiation dose rates within distances of 0.1–3.0 m,with a deviation of less than 11%compared to observed rates.The model demonstrated greater accuracy at shorter distances from the radiation source,with a deviation of only 1.55%from observed values at 0.1 m.Discussion:The model proposed in this study effectively represents the spatial and temporal distribution of the radiation field around nuclear medicine patients and demonstrates good agreement with actual measurements.This model has the potential to serve as a radiation dose rate alert system in hospital environments.

Effects of Seasonal and Temperature Variations on the Association between Nitrogen Dioxide Exposure and First-Aid Incidence for Neurological Diseases in Shenzhen,China

Neurological disorders,including headaches(tension-type headaches,medication-overuse headaches,and migraines)and dementias that include Alzheimer’s disease,are among the most prevalent and debilitating global conditions.In 2016,these disorders affected 276 million people worldwide and were the second leading cause of death that year[1].This highlights the urgent need for effective prevention,treatment,and support strategies.The etiology of neurological disorders is multifaceted and involves genetic,environmental,physiological,and social factors[2].

基于功能性状的水杉原生母树种群生境适应策略

植物的功能性状变异和表型可塑性是其应对异质生境的主要机制,对植物的生长和分布有重要贡献。本文以湖北星斗山国家级自然保护区的水杉(Metasequoia glyptostroboides)原生母树为研究对象,分析了母树种群功能性状对树木形态、地形因子及人为干扰的响应机制。结果表明:水杉原生母树叶面积、叶干重和比叶面积的变异幅度大,可塑性较强,而枝和叶的干物质含量稳定性最高。人为干扰和4个地形因子均对每个功能性状变异方差有5%–20%的解释度,冠幅对枝、叶干物质含量的变异方差有高达38%和76%的解释度。5个功能性状主要受海拔、坡位和人为干扰影响,其中,比叶面积对环境因子和干扰的响应规律不明显,叶面积和叶干重在强烈人为干扰的环境中普遍增大,枝和叶的干物质含量对坡向的变化最敏感。总之,水杉原生母树种群通过功能性状变异对环境能产生一定的可塑性响应,但人为干扰对母树生长影响较大,建议人工辅助更新,并适度减少农业和建筑对现存母树的影响。

Perfecting and extending the near-infrared imaging window

In vivo fluorescence imaging in the second near-infrared window(NIR-II)has been considered as a promising technique for visualizing mammals.However,the definition of the NIR-II region and the mechanism accounting for the excellent performance still need to be perfected.Herein,we simulate the photon propagation in the NIR region(to 2340 nm),confirm the positive contribution of moderate light absorption by water in intravital imaging and perfect the NIR-II window as 900–1880 nm,where 1400–1500 and 1700–1880 nm are defined as NIR-IIx and NIR-IIc regions,respectively.Moreover,2080–2340 nm is newly proposed as the third near-infrared(NIR-III)window,which is believed to provide the best imaging quality.The wide-field fluorescence microscopy in the brain is performed around the NIRIIx region,with excellent optical sectioning strength and the largest imaging depth of intravital NIR-II fluorescence microscopy to date.We also propose 1400 nm long-pass detection in off-peak NIR-II imaging whose performance exceeds that of NIR-IIb imaging,using bright fluorophores with short emission wavelength.

Effect of Al_(82.8)Cu_(17)Fe_(0.2) alloy doping on structure and magnetic properties of SmCo5-based ribbons

This work tries to improve the magnetic properties by multi-element doping in the form of a ternary alloy.SmCo_(5+)χwt%Al-Cu-Fe(x=0-7)ribbons melt-spun at 40 m/s were produced by adding Al_(82.8)Cu_(17)Fe_(0.2)alloy into SmCo_(5) matrix,and their phases,microstructure,and magnetic properties were investigated.The results show that both x=0 and 3 ribbons form a cellular microstructure.Al-Cu-Fe addition reduces the content of the Sm_(2)(Co,M)_(7) cell wall,narrows its width,and forms the local disordered micro-regions and solute-segregation nanoclusters in the Sm(Co,M)_(5) grains.With x increasing to5,Al-Cu-Fe addition promotes the phase separation between and within grains of the SmCo_(5)-based alloy.The Al-Cu-Fe addition can simultaneously improve the coercivity and magnetization of the SmCo_(5)-based ribbons,in particular,the magnetization of the x=3 ribbons increases by 35%,while the coercivity of the x=5 ribbons increases by 3.9 times.Finally,the microstructure evolution models are built up,and the relationship between the microstructure and the magnetic properties is discussed.