Prostate homeostasis and regeneration rely on the proper function of adult stem/progenitor cells(Ousset et al., 2012), which have also been considered as potential cells of origin for prostate cancer(Visvader, 2011) g...Prostate homeostasis and regeneration rely on the proper function of adult stem/progenitor cells(Ousset et al., 2012), which have also been considered as potential cells of origin for prostate cancer(Visvader, 2011) given their key positions in the lineage hierarchy and self-renewal capability. Accumulating evidence reveals the existence of multipotent progenitor cells in both basal and luminal cells.展开更多
T lymphocytes bearing c-and d-chain T-cell receptor heterodimers are named cd T cells.Interestingly,cd and ab T cells share the same progenitors,and they undergo a fate decision in the thymus.Functional differentiatio...T lymphocytes bearing c-and d-chain T-cell receptor heterodimers are named cd T cells.Interestingly,cd and ab T cells share the same progenitors,and they undergo a fate decision in the thymus.Functional differentiation of cd T cells occurs both inside and outside the thymus.Antigen recognition of cd T-cell receptors is very unique,and the responses frequently exhibit innate characteristics.Nevertheless,peripheral cd T cells exert a number of effector and regulatory functions.cd T cells rapidly produce cytokines like interferon(IFN)-c and IL-17 and promote inflammation,partly due to the inherent epigenetic and transcriptional programs,which facilitates a quick and extensive response.Moreover,cd T cells lyse target cells directly,and this is necessary for pathogen or tumor clearance.cd T cells can even serve as regulatory cells,and may contribute to immune suppression.Orchestration of cd T-cell and other immune cell interactions may be critical for host defense and immune regulation.Recently,cd T cells have been used for immunotherapy for infectious diseases and malignancy.In this review,we summarize the abstracts presented at the recent cd T cell Conference held from 19 to 21 May 2010,in Kiel,Germany(please see the website for details:http://www.gammadeltaconference.uni-kiel.de/index.html).展开更多
基金supported by the grant JCYJ20200109141229255 from Science, Technology and Innovation Commission of Shenzhen Municipalitysupported by grants R01CA171189 and R01CA193455 from the National Cancer Institute, National Institutes of Healthsupported in part by the Emory Integrated Genomics Core, Integrated Cellular Imaging Core Facility, Winship Research Pathology Core, and Transgenic Mouse and Gene Targeting Core of Emory University Winship Cancer Institute and NIH/NCI under award number P30CA138292。
文摘Prostate homeostasis and regeneration rely on the proper function of adult stem/progenitor cells(Ousset et al., 2012), which have also been considered as potential cells of origin for prostate cancer(Visvader, 2011) given their key positions in the lineage hierarchy and self-renewal capability. Accumulating evidence reveals the existence of multipotent progenitor cells in both basal and luminal cells.
基金by grants from the National Basic Research Program of China(2007CB914801)the National Outstanding Young Scientist Award of National Natural Science Foundation of China(30725015).
文摘T lymphocytes bearing c-and d-chain T-cell receptor heterodimers are named cd T cells.Interestingly,cd and ab T cells share the same progenitors,and they undergo a fate decision in the thymus.Functional differentiation of cd T cells occurs both inside and outside the thymus.Antigen recognition of cd T-cell receptors is very unique,and the responses frequently exhibit innate characteristics.Nevertheless,peripheral cd T cells exert a number of effector and regulatory functions.cd T cells rapidly produce cytokines like interferon(IFN)-c and IL-17 and promote inflammation,partly due to the inherent epigenetic and transcriptional programs,which facilitates a quick and extensive response.Moreover,cd T cells lyse target cells directly,and this is necessary for pathogen or tumor clearance.cd T cells can even serve as regulatory cells,and may contribute to immune suppression.Orchestration of cd T-cell and other immune cell interactions may be critical for host defense and immune regulation.Recently,cd T cells have been used for immunotherapy for infectious diseases and malignancy.In this review,we summarize the abstracts presented at the recent cd T cell Conference held from 19 to 21 May 2010,in Kiel,Germany(please see the website for details:http://www.gammadeltaconference.uni-kiel.de/index.html).
