Biochemical markers for non-invasive assessment of disease stage in patients with primary biliary cirrhosis

AIM: To evaluate different biochemical markers and their ratios in the assessment of primary biliary cirrhosis (PBC) stages. METHODS: This study included 112 patients with PBC who underwent a complete clinical investigation. We analyzed the correlation (Spearman's test) between ten biochemical markers and their ratios with different stages of PBC. The discriminative values were compared using areas under receiver operating characteristic (ROC) curves. RESULTS: The mean age of patients included in the study was 53.88 ± 10.59 years, including 104 females and 8 males. We found a statistically significant correlation between PBC stage and Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) to platelet ratio (APRI), ALT/platelet count, AST/ALT, ALT/AST and ALT/Cholesterol ratios, with the values of Spearman's rho of 0.338, 0.476, 0.404, 0.356, 0.351 and 0.325, respectively. The best sensitivity and specificity was shown for AST/ALT, with an area under ROC of 0.660. CONCLUSION: Biochemical markers and their ratios do correlate with different sensitivity to and specificity of PBC disease stage. The use of biochemical markers and their ratios in clinical evaluation of PBC patients may reduce, but not eliminate, the need for liver biopsy.

Right liver lobe/albumin ratio:Contribution to non-invasive assessment of portal hypertension

瞄准：学习价值生物化学并且在存在的预言和食道的静脉曲张的尺寸的 ultraso-nographic 参数。方法：学习包括经历了一个完全的生物化学的工作在上面的选择肝脏硬化症的病人，上面内视镜的 digestive 和 ultrasonographic 考试。白朊 / 权利肝脑叶直径和血小板计数 / 脾直径比率是计算的。在食道的静脉曲张的计算比率和存在和度之间的关联被评估。结果：94 个题目(62 男性， 32 女性) ，与 52.32 +/- 的吝啬的年龄 13.60 年，被学习。孩子呸班 A 占了 42.6% ，班 B 37.2% ，而班 C 20.2% 。，食道的静脉曲张(OE ) 没被上面的消化内视镜检查法在 24.5% 表明我在 22.3% 病人，被发现的 OE 等级在 33.0% 分级 II，在 16.0% 分级 III，并且分级在 4.3% 的 IV。正确的肝脑叶直径 / 白朊比率的吝啬的价值是 5.51 +/- 1.82 (从 2.76 ～ 11.44 的范围) 当吝啬的血小板计数 / 脾直径比率是 1017.75 +/- 时 729.36 (从 117.39 ～ 3362.50 的范围) 分别地。统计上重要的关联被枪兵在 OE 等级和计算比率之间的测试证明。P 价值是 0.481 并且 -0.686, 分别地。结论：正确的肝脑叶直径 / 白朊和血小板计数 / 脾直径比率是提供对食道的静脉曲张，并且他们与肝肝硬化在病人分级的存在的决心恰当的精确信息的非侵略的参数。