Genetic factors may play a role in susceptibility to stroke. The angiotensin converting enzyme (ACE) gene is a candidate gene for two phenotypically different types of stroke affecting small perforating arteries: spon...Genetic factors may play a role in susceptibility to stroke. The angiotensin converting enzyme (ACE) gene is a candidate gene for two phenotypically different types of stroke affecting small perforating arteries: spontaneous intracerebral hemorrhage (SIH) and ischemic stroke due to small vessel disease (SVD). The authors report evidence that ACE gene DD homozygosity of the I/D polymorphism in intron 16 is an independent risk factor for SIH, and not for SVD stroke, in a Polish population.展开更多
Background: Although substantial numbers of stroke patients suffer from apathy, its causes are still poorly understood. Previous studies suggest that dysfunction of the frontal lobes is implicated in the pathophysiolo...Background: Although substantial numbers of stroke patients suffer from apathy, its causes are still poorly understood. Previous studies suggest that dysfunction of the frontal lobes is implicated in the pathophysiology of motivation. Our aim was to investigate the association between proton magnetic resonance spectr oscopy (H1-MRS) measurements in unaffected frontal lobes and apathy in a group of first-time stroke patients. Methods: 31 patients with a first-time ischemic stroke located outside the frontal lobes and 20 healthy subjects were included in the study. The authors performed single voxel H1-MRS in order to measure the N-acetylaspartate/creatine (NAA)/Cr, glutamate +glutamine (Glx)/Cr, choline ( Cho)/Cr and myo-inositol (mI)/Cr ratios in the frontal lobes. Patients were ass essed between days 7 and 12 post stroke. Diagnosis of apathy was made on the bas is of clinical observation, interview and Apathy Scale. Results: 13 out of 31 patients (42%) demonstrated apathy. Patie nts with apathy had lower NAA/Cr ratios in the right frontal lobe than non-apat hetic subjects. The patient group was divided into two subgroups: Those with lef t hemisphere strokes, and those with right hemisphere strokes. Of these subjects , significantly lowered NAA/Cr ratios were found in the right hemispheres of apa thetic patients in the subgroup with left-sided brain lesions. Conclusions: The se findings point to the association between apathy and frontal lobe integrity, suggest different reactions of the hemispheres and indicate that changes in the NAA/Cr ratio are related to the apathy.展开更多
文摘Genetic factors may play a role in susceptibility to stroke. The angiotensin converting enzyme (ACE) gene is a candidate gene for two phenotypically different types of stroke affecting small perforating arteries: spontaneous intracerebral hemorrhage (SIH) and ischemic stroke due to small vessel disease (SVD). The authors report evidence that ACE gene DD homozygosity of the I/D polymorphism in intron 16 is an independent risk factor for SIH, and not for SVD stroke, in a Polish population.
文摘Background: Although substantial numbers of stroke patients suffer from apathy, its causes are still poorly understood. Previous studies suggest that dysfunction of the frontal lobes is implicated in the pathophysiology of motivation. Our aim was to investigate the association between proton magnetic resonance spectr oscopy (H1-MRS) measurements in unaffected frontal lobes and apathy in a group of first-time stroke patients. Methods: 31 patients with a first-time ischemic stroke located outside the frontal lobes and 20 healthy subjects were included in the study. The authors performed single voxel H1-MRS in order to measure the N-acetylaspartate/creatine (NAA)/Cr, glutamate +glutamine (Glx)/Cr, choline ( Cho)/Cr and myo-inositol (mI)/Cr ratios in the frontal lobes. Patients were ass essed between days 7 and 12 post stroke. Diagnosis of apathy was made on the bas is of clinical observation, interview and Apathy Scale. Results: 13 out of 31 patients (42%) demonstrated apathy. Patie nts with apathy had lower NAA/Cr ratios in the right frontal lobe than non-apat hetic subjects. The patient group was divided into two subgroups: Those with lef t hemisphere strokes, and those with right hemisphere strokes. Of these subjects , significantly lowered NAA/Cr ratios were found in the right hemispheres of apa thetic patients in the subgroup with left-sided brain lesions. Conclusions: The se findings point to the association between apathy and frontal lobe integrity, suggest different reactions of the hemispheres and indicate that changes in the NAA/Cr ratio are related to the apathy.
