In this paper, cucurbit[7]uril(CB[7])-mediated three-dimensional gold nanoassemblies were successfully prepared to increase the loaded amount of CB[7] and enhance the electrochemical detection of amino acids. Particle...In this paper, cucurbit[7]uril(CB[7])-mediated three-dimensional gold nanoassemblies were successfully prepared to increase the loaded amount of CB[7] and enhance the electrochemical detection of amino acids. Particle sizes of gold nanoparticles(Au NPs) significantly affect stability and detection sensitivity of nanoassemblies. The volume of gold nanoassemblies first increased and then decreased with the increase of CB[7] concentration. The 3D gold nanoassemblies composed of 16 nm Au NPs and 100 μmol/L CB[7]had excellent stability and maximum volume, exhibiting more sensitive detection for a variety of amino acids. And the detection limits of aromatic amino acids are lower in virtue of the higher binding constant between aromatic amino acids and CB[7]. This study will develop and deepen our understanding of molecular recognition in amino acids detection.展开更多
Chirality is a fascinating and essential feature of life and highly associated with many significant pharmaceutical,chemical,and biological processes.The construction of chiral recognition platform is a hot research t...Chirality is a fascinating and essential feature of life and highly associated with many significant pharmaceutical,chemical,and biological processes.The construction of chiral recognition platform is a hot research topic and challenging assignment.Herein,we report an electrochemical method by diffe rential pulse voltammetry(DPV) for the enantioselective recognition of chiral drug propranolol(R/SPPL) through a nanochannel platform based on the N-acetyl-L-cysteine functionalized pillar[5]arenes derivative NALC-P5 and the porous polycarbonate membrane.The chiral discrimination depends on the diffe rence in the supramolecular host-guest interaction between the chiral NALC-P5 and the R/S-PPL.The transmission rate of the R/S-PPL can be regulated in the nanochannel and we can achieve the selective transport of the chiral drugs.This simple electrochemical technique has potential applications as a general platform for the recognition of chiral molecules.展开更多
基金supported in part by grants from the National Natural Science Foundation of China (No. 21871108)the Program for Innovative Teams of Outstanding Young and Middle-Aged Researchers in the Higher Education Institutions of Hubei Province(No. T201702)。
文摘In this paper, cucurbit[7]uril(CB[7])-mediated three-dimensional gold nanoassemblies were successfully prepared to increase the loaded amount of CB[7] and enhance the electrochemical detection of amino acids. Particle sizes of gold nanoparticles(Au NPs) significantly affect stability and detection sensitivity of nanoassemblies. The volume of gold nanoassemblies first increased and then decreased with the increase of CB[7] concentration. The 3D gold nanoassemblies composed of 16 nm Au NPs and 100 μmol/L CB[7]had excellent stability and maximum volume, exhibiting more sensitive detection for a variety of amino acids. And the detection limits of aromatic amino acids are lower in virtue of the higher binding constant between aromatic amino acids and CB[7]. This study will develop and deepen our understanding of molecular recognition in amino acids detection.
基金financially supported by the National Key Research and Development Program of China(No.2018YFD0200102)the National Natural Science Foundation of China(Nos.21772055,21572076,21807083,21911530178)+1 种基金the Program for Innovative Teams of Outstanding Young and Middleaged Researchers in the Higher Education Institutions of Hubei Province(No.T201702)the 111 Project(No.B17019E)。
文摘Chirality is a fascinating and essential feature of life and highly associated with many significant pharmaceutical,chemical,and biological processes.The construction of chiral recognition platform is a hot research topic and challenging assignment.Herein,we report an electrochemical method by diffe rential pulse voltammetry(DPV) for the enantioselective recognition of chiral drug propranolol(R/SPPL) through a nanochannel platform based on the N-acetyl-L-cysteine functionalized pillar[5]arenes derivative NALC-P5 and the porous polycarbonate membrane.The chiral discrimination depends on the diffe rence in the supramolecular host-guest interaction between the chiral NALC-P5 and the R/S-PPL.The transmission rate of the R/S-PPL can be regulated in the nanochannel and we can achieve the selective transport of the chiral drugs.This simple electrochemical technique has potential applications as a general platform for the recognition of chiral molecules.
