基于声子晶体的高速列车地板支撑层隔声研究

随着高速列车运营速度不断提高,轨道交通产生的振动噪声会严重影响列车的车内声环境,进而降低乘坐舒适性,因此针对列车噪声源部位的车体隔声设计至关重要。目前的隔声措施能够有效控制车内中高频噪声,而对于低频噪声的抑制效果还有待进一步提升。声子晶体是一种具有弹性波带隙的周期性结构材料,该结构不需要大尺寸即可在局域共振作用下形成低频带隙,进而抑制弹性波的传播从而起到低频降噪作用。基于声子晶体周期性理论,以车辆转向架部位地板的木骨支撑层为对象,研究声子晶体在木骨支撑层隔声中的应用,系统分析声子晶体结构的带隙特性和隔声特性以及基于声子晶体结构的支撑层隔声性能。研究结果表明:通过改变结构形式及其参数可实现对于声子晶体结构的带隙形成频带及其隔声特性的人为设计和控制;以高速列车地板中的木骨结构为对象,结合声子晶体理论将其设计为木骨和声子晶体组合结构形式,不仅能够保持声子晶体在0~220 Hz低频段和620~710 Hz频段优越的隔声性能,同时可极大提升220~620 Hz频段的隔声性能;既维持该层结构的支撑作用,又能很好提升隔声性能,在高速列车地板设计中具有很强的有效性和适用性。

高速列车轮轨噪声控制的新型声屏障设计方法研究

我国轨道交通的基础建设已得到快速发展。随着新版《中华人民共和国噪声污染防治法》的实施,轨道交通对于沿线声环境的污染防治也将成为后期重点关注的问题之一,因此有必要提高轨道交通重要降噪设备声屏障在隔声性能方面的要求;针对轨道交通轮轨噪声的频段范围,基于Bragg带隙机理提出了三种针对轨道交通轮轨噪声的新型的二维气-固声子晶体型能带结构设计方案,分析了三种设计方案对应的带隙特性,并通过声传递损失评价了三种设计方案的隔声效果。研究表明:结合声子晶体理论设计的能带结构排布方式,能够对特定频段内的轮轨噪声形成高效的阻隔;通过合理设计散射体的布置形式和几何参数,可进一步实现特定多频段的有效隔声;将提出的方案应用于声屏障设计,能针对性地提升声屏障的隔声性能。

推动振兴中西部高等教育大发展——《迈向公平之路——慕课西部行发展报告》序言二

“慕课西部行计划”是教育部支持下,各地、各校利用数字技术开启建设教育强国的全新探索。在1.0阶段(2013—2021年),以慕课为抓手,解决西部高校普遍缺乏通识课的“燃眉之急”,精准对接西部高校部分缺少专业课的“当务之需”。在2.0阶段(2021年以后),以慕课为主体丰富建设内涵,不仅将实验资源、图书文献纳入计划之中,同时不断创新教学、管理和组织模式,助力实现更高效、更公平和可持续的高等教育。

Nuclear PLD1 combined with NPM1 induces gemcitabine resistance through tumorigenic IL7R in pancreatic adenocarcinoma

Objective:Pancreatic ductal adenocarcinoma(PDAC)is a highly malignant gastrointestinal cancer with a 5-year survival rate of only 9%.Of PDAC patients,15%-20%are eligible for radical surgery.Gemcitabine is an important chemotherapeutic agent for patients with PDAC;however,the efficacy of gemcitabine is limited due to resistance.Therefore,reducing gemcitabine resistance is essential for improving survival of patients with PDAC.Identifying the key target that determines gemcitabine resistance in PDAC and reversing gemcitabine resistance using target inhibitors in combination with gemcitabine are crucial steps in the quest to improve survival prognosis in patients with PDAC.Methods:We constructed a human genome-wide CRISPRa/dCas 9 overexpression library in PDAC cell lines to screen key targets of drug resistance based on sgRNA abundance and enrichment.Then,co-IP,ChIP,ChIP-seq,transcriptome sequencing,and qPCR were used to determine the specific mechanism by which phospholipase D1(PLD1)confers resistance to gemcitabine.Results:PLD1 combines with nucleophosmin 1(NPM1)and triggers NPM1 nuclear translocation,where NPM1 acts as a transcription factor to upregulate interleukin 7 receptor(IL7R)expression.Upon interleukin 7(IL-7)binding,IL7R activates the JAK1/STAT5 signaling pathway to increase the expression of the anti-apoptotic protein,BCL-2,and induce gemcitabine resistance.The PLD1 inhibitor,Vu0155069,targets PLD1 to induce apoptosis in gemcitabine-resistant PDAC cells.Conclusions:PLD1 is an enzyme that has a critical role in PDAC-associated gemcitabine resistance through a non-enzymatic interaction with NPM1,further promoting the downstream JAK1/STAT5/Bcl-2 pathway.Inhibiting any of the participants of this pathway can increase gemcitabine sensitivity.

Amorphous gallium oxide homojunction-based optoelectronic synapse for multi-functional signal processing

In the era of accelerated development in artificial intelligence as well as explosive growth of information and data throughput,underlying hardware devices that can integrate perception and memory while simultaneously offering the bene-fits of low power consumption and high transmission rates are particularly valuable.Neuromorphic devices inspired by the human brain are considered to be one of the most promising successors to the efficient in-sensory process.In this paper,a homojunction-based multi-functional optoelectronic synapse(MFOS)is proposed and testified.It enables a series of basic electri-cal synaptic plasticity,including paired-pulse facilitation/depression(PPF/PPD)and long-term promotion/depression(LTP/LTD).In addition,the synaptic behaviors induced by electrical signals could be instead achieved through optical signals,where its sen-sitivity to optical frequency allows the MFOS to simulate high-pass filtering applications in situ and the perception capability integrated into memory endows it with the information acquisition and processing functions as a visual system.Meanwhile,the MFOS exhibits its performances of associative learning and logic gates following the illumination with two different wave-lengths.As a result,the proposed MFOS offers a solution for the realization of intelligent visual system and bionic electronic eye,and will provide more diverse application scenarios for future neuromorphic computing.

Surgical treatment of pulsatile tinnitus related to the sigmoid sinus

Objective: Tinnitus-a common clinical symptom-can be categorized into pulsatile tinnitus(PT) and non-PT. Among these, PT is usually associated with sigmoid sinus symptoms, such as sigmoid sinus wall defect or diverticulum, for which various surgical treatments are available. We have discussed the clinical efficacy of surgery for sigmoid sinus-associated PT via the transmastoid approach in this study.Methods: We conducted a retrospective review of 4 patients who underwent surgery for sigmoid sinusassociated PT via the transmastoid approach at Nanjing Drum Tower Hospital from January to December2020. Of these, 2 patients had sigmoid sinus wall defect and 2 had sigmoid sinus diverticulum. Postoperative tinnitus grading and surgical efficacy were determined.Results: After surgery, PT dissolved in 3 patients, while tinnitus significantly decreased in 1 patient.During the follow-up period of 12-18 months, none of the 4 patients showed complications related to increased intracranial pressure or venous sinus thrombosis, and tinnitus symptoms disappeared in 3patients without recurrence, although 1 patient occasionally developed tinnitus. Postoperative thin-slice CTA of the temporal bone indicated that the sigmoid sinus bone wall defect or diverticulum was completely repaired with a thick soft tissue coverage.Conclusion: Surgical repair of sigmoid sinus-associated PT via the transmastoid approach deserves clinical promotion as it exhibited better efficiency while being relatively less invasive.

Enhancing hydrophobicity via core-shell metal organic frameworks for high-humidity flue gas CO_(2) capture

Developing metal-organic framework(MOF)materials with the moisture-resistant feature is highly desirable for CO_(2)capture from highly humid flue gas.In this work,a new core-shell MOF@MOF composite using Mg-MOF-74 with high CO_(2)capture capacity as a functional core and hydrophobic zeolitic imidazolate framework-8(ZIF-8)as a protective shell is fabricated by the epitaxial growth method.Experimental results show that the CO_(2)adsorption performance of the core-shell structured Mg-MOF-74@ZIF-8 composites from water-containing flue gas is enhanced along with their improved hydrophobicity.The dynamic breakthrough results show that the Mg-MOF-74@ZIF-8 with three assembled layers(Mg-MOF-74@ZIF-8-3)can capture 3.56 mmol-g^(-1)CO_(2)from wet CO_(2)/N_(2)(VCO_(2):V_(N_(2))=15:85)mixtures,which outperforms Mg-MOF-74(0.37 mmol·g^(-1))and most of the reported physisorbents.

Effects of fluorination on crystal structure and electrochemical performance of antiperovskite solid electrolytes

The development of all-solid-state lithium batteries(ASSLBs)depends on exploiting solid-state electrolytes(SSEs)with high ionic conductivity and electrochemical stability.Fluorination is generally considered to be an effective strategy to improve the ionic conductivity and electrochemical stability of inorganic SSEs.Here,we report the partial fluorination of the chlo rine sites in an antiperovskite,by which the orthorhombic Li_(2)OHCl was transformed into cubic Li_(2)OHCl_(0.9)F_(0.1),resulting in a fourfold increase in ionic conductivity at 30℃.The ab initio molecular dynamics simulations suggest that both the crystal symmetry and the anions electronegativity influence the diffusion of Li+in the antiperovskite structure.Besides,from the perspective of experiments and calculations,it is confirmed that fluorination is a feasible method to improve the electrochemical stability of antiperovskite SSEs.The LiFePO_(4)|Li cell based on Li_(2)OHCl_(0.9)F_(0.1) is also assembled and exhibits stable cycle performance,which indicates that fluorination of antiperovskite SSEs is an effective way to produce high-performance SSEs for practical application of ASSLBs.

Genome resequencing reveals the evolutionary history of garlic reproduction traits

The propagation of cultivated garlic relies on vegetative cloves,thus flowers become non-essential for reproduction in this species,driving the evolution of reproductive feature-derived traits.To obtain insights into the evolutionary alteration of reproductive traits in the clonally propagated garlic,the evolutionary histories of two main reproduction-related traits,bolting and flower differentiation,were explored by genome analyses using 134 accessions displaying wide diversity in these two traits.Resequencing identified 272.8 million variations in the garlic genome,198.0million of which represent novel variants.Population analysis identified five garlic groups that have evolved into two clades.Gene expression,single-cell transcriptome sequencing,and genome-wide trait association analyses have identified numerous candidates that correlate with reproductive transition and flower development,some of which display distinct selection signatures.Selective forces acting on the B-box zinc finger protein-encoding Asa2G00291.1,the global transcription factor group E protein-encoding Asa5G01527.1,and VERNALIZATION INSENSITIVE 3-like Asa3G03399.1 appear to be representative of the evolution of garlic bolting.Plenty of novel genomic variations and trait-related candidates represent valuable resources for biological studies of garlic.Numerous selective signatures from genes associated with the two chosen reproductive traits provide important insights into the evolutionary history of reproduction in this clonally propagated crop.

晚第四纪MIS6以来柴达木盆地成盐作用对冰期气候的响应

气候是控制柴达木盆地盐类沉积的主要因素之一,但是其作用机制尚待明确。作者以柴达木盆地察汗斯拉图盐湖的3个含盐剖面为研究对象,采用多接收电感耦合等离子质谱(MC-ICP-MS)铀系测年测定其沉积时代,并通过X射线粉晶衍射(XRD)分析测定其盐类矿物种类。铀系测年显示D18剖面石盐和芒硝层的沉积时代为13.1±2.0 ka BP^15.9±2.5 ka BP,其中芒硝沉积年代属于末次冰期MIS2晚期;MXK2剖面芒硝层的沉积时代分别为131.7±39.5 ka BP和158.3±10.8 ka BP,D12剖面芒硝层的沉积时代分别为166.6±20.2 ka BP和198.0±20.6 ka BP,可以对应于倒数第二次冰期MIS6。XRD分析确定了3个剖面的盐类矿物主要为芒硝、石盐和石膏。综合多个盐湖晚第四纪成盐数据,本文认为倒数第二次冰期MIS6和末次冰期MIS2是柴达木盆地晚第四纪重要的成盐期,冰期的冷干气候有利于石盐和芒硝等盐类沉积。柴达木盆地"冰期成盐"的根本原因,是由于冰期环境下盆地周边山体冰川规模的扩张以及干冷的冰期气候,共同造成了盐湖补给水量的减少。此外,晚第四纪MIS6和MIS2的冰期降温也是导致盆地中冷相盐类沉积的直接原因。

Assessment of the Safety Impacts of a Pit Construction on the Neighboring Subway

In order to study the impact of pit excavation on the adjacent existing subway structure,the safety impact assessment of a project was carried out using project under construction near the subway as the engineering background.The results show that the new pit construction will produce some additional deformation on the existing subway interval structure,the deformation values are within the permissible range for safe operation.Through analysis of the results,the risk point rating of the pit adjacent to the interval is level 2.In general,the impacts of the pit construction on the neighboring subway structure are less than the specification limits.

不同引发剂量对纤维状聚苯胺电化学性能的影响

以樟脑磺酸为掺杂酸,采用低温化学氧化聚合法合成了纤维状聚苯胺。通过透射电镜、扫描电镜、红外光谱等探讨了单体苯胺与引发剂过硫酸铵的摩尔比对聚苯胺形貌和结构的影响。利用循环伏安、恒流充放电以及交流阻抗等技术对样品的电化学性能进行了测试。结果表明,苯胺与过硫酸铵摩尔比为2:1获得的聚苯胺在电流密度为0.5 A/g时的比电容最高,为762.4 F/g。甚至在高电流密度下(10 A/g)仍保持530.6 F/g的比电容。经1000圈的恒流充放电后,容量保持率为74.4%。相比之下,优化的聚苯胺具有最高的比电容和倍率特性,在超级电容器中有广泛的应用前景。

多靶点疗法治疗狼疮性肾炎的安全性与有效性评价

目的评价激素联合他克莫司(TAC)、霉酚酸酯(MMF)和环磷酰胺(IVC)多靶点治疗狼疮性肾炎(LN)的有效性和安全性。方法系统检索PubMed、Embase、Cochrane Library、CBM、CNKI、万方、维普数据库。收集多靶点诱导治疗LN的随机对照试验(RCT),应用Review Manager 5.3软件对数据进行Meta分析。结果共10篇国内进行的RCT共计1151例患者被纳入到本次Meta分析中,结果显示多靶点组的完全缓解率高于IVC组(RR:1.83,95%CI:1.59～2.11,P <0.000 01),但对Ⅲ型、Ⅴ+Ⅲ型的LN患者,多靶点治疗无明显优势;与IVC组相比,多靶点组抗dsDNA转阴率高,SLEDAI评分变化、血清白蛋白升高和尿蛋白减少更明显,且胃肠道反应、白细胞减少、肝功能异常、脱发和月经失调的发生率明显低于IVC组,但新发高血压的发生率高于IVC组,感染和高血糖的发生率比较,差异均无统计学意义。结论对我国Ⅳ型、Ⅴ型和Ⅴ+Ⅳ型的LN患者,多靶点治疗疗效优于IVC组,且安全性更高。

微针介导的浅表肿瘤治疗研究进展

作为一种新兴的给药方式,微针透皮给药具有微创无痛、安全高效、使用方便及改善患者依从性等优点。在浅表肿瘤治疗中,微针可以有效刺穿皮肤角质层,将负载的药物高效传递并富集于肿瘤部位,从而避免肝脏首过效应,防止胃肠道副作用,可极大地提高药物的利用率。在相同剂量下,相对于静脉注射给药及肿瘤内注射给药,微针透皮给药表现出更好的治疗效果。综述近年来微针结合化学疗法、光热疗法、光动力疗法、基因疗法、免疫疗法等在浅表肿瘤治疗中的研究进展,对于未来开创微创、局部精准给药、高效开展浅表肿瘤治疗具有指导意义。

青藏高原中部色林错中晚全新世以来古气候变化特征

色林错位于青藏高原中部印度季风和西风环流的过渡地带,同时受西风环流和印度季风系统控制,是研究二者进退变化特征的理想场所。本文利用色林错SL-1钻孔中介形虫Limnocythere inopinata的丰度及其壳体微量元素Mg/Ca和Mn/Ca比值重建了色林错5.3 ka BP以来的古气候环境变化特征。5.3~2.9 ka BP,L.inopinata丰度较小,壳体的低Mg/Ca比值和高Mn/Ca比值表明此阶段气候偏冷湿;2.9~1.8 ka BP,L.inopinata丰度较前一阶段增加,壳体Mg/Ca比值略有增长但仍为低值表明气温虽然有所回升但仍然较低,Mn/Ca比值较前一阶段明显降低,指示湖泊水位下降;1.8 ka BP至今,L.inopinata丰度达到最大,壳体的高Mg/Ca和Mn/Ca比值指示湖泊温度和水位均呈显著的上升趋势。通过与西风区、过渡区以及印度季风区其他湖泊的环境沉积记录对比,本文认为青藏高原中部地区在中全新世晚期主要受西风环流影响,气温较低,西风带来大量水汽使得湖面呈扩张趋势;而到晚全新世西风环流逐渐北撤,色林错受季风影响更大,季风带来的降水和气温升高导致的冰川融水增加与色林错水位上升有密切关系。

填充阻尼块网孔式弹性垫板力学参数影响研究

为了提高网孔式弹性垫板的阻尼,对填充平面型阻尼块网孔式弹性垫板进行结构优化,得到阻尼性能更好的曲面型阻尼块网孔式弹性垫板。在保证材料参数和尺寸参数一致的情况下,研究填充曲面型阻尼块网孔式弹性垫板的倒角半径、网孔间距和网孔衍生方式对其静刚度和阻尼比特性的影响规律,并将其与普通网孔式弹性垫板和填充平面型阻尼块网孔式弹性垫板进行对比。研究结果表明:增大填充曲面型阻尼块网孔式弹性垫板的倒角半径,其静刚度和阻尼比均会随之增大;网孔间距的增大会使填充平面型阻尼块网孔式弹性垫板的静刚度增大,阻尼比则随之减小。不同的网孔衍生方式对填充平面型阻尼块网孔式弹性垫板的静刚度和阻尼比影响不大,但边平行网孔衍生方式可以有效地降低弹性垫板本体和阻尼块的整体应力水平。同时,2种填充阻尼块网孔式弹性垫板在刚度一致的情况下,填充曲面型阻尼块网孔式弹性垫板具有更好的阻尼特性,且其应力水平更小,在提高减振性能的同时也延长了弹性垫板的使用寿命。该弹性垫板相比于填充平面型阻尼块网孔式弹性垫板更节省材料,有利于降低生产成本。

A comparative study between Embosphere~ and conventional transcatheter arterial chemoembolization for treatment of unresectable liver metastasis from GIST

Objective:Transcatheter arterial chemoembolization(TACE) is a standard treatment for hepatocellular carcinoma(HCC) and/or some unresectable liver metastasis tumors.Hypervascular liver metastatic lesions such as metastasis from gastrointestinal stromal tumor(GIST) are an indication for transcatheter arterial embolization(TAE).The purpose of this study was to evaluate the efficacy and safety of Embosphere~-TAE(Embo-TAE) in comparison with conventional TACE(cTACE) for the treatment of liver metastasis from GIST.Methods:A total of 45 patients who underwent TACE between Aug 2008 and Feb 2013 were enrolled.Patients with GIST who underwent TAE with Embosphere~(n=19) were compared with controls who received cTACE(n=26).The primary end points were treatment response and treatment-related adverse events.The secondary end points were progression-free survival(PFS) and overall survival(OS).Results:The treatment response of Embo-TAE group was significantly higher than that of the cTACE group(P<0.001).The PFS was significantly better in the Embosphere~-group than in the cTACE group(56.6 and 42.1 weeks,respectively;P=0.003).However,there was no statistically significant difference in liver toxicity between the two groups(P>0.05).The median OS in the Embo-TAE group was longer than that in the cTACE group(74.0 weeks,95% CI:68.2-79.8 vs.61.7 weeks,95% CI:56.2-67.2 weeks)(unadjusted P=0.045).The use of Embo-TAE significantly reduced the risk of death in patients with GIST with liver metastases according to the Cox proportional hazards regression model [hazard ratio(HR):0.149;95% CI:0.064-0.475].Conclusions:TAE with Embosphere~ showed better treatment response and delayed tumor progression compared with cTACE.There was no significant difference in treatment-related hepatic toxicities.EmboTAE thus appears to be a feasible and promising approach in the treatment of liver metastasis from GIST.

Hepatic artery infusion with raltitrexed or 5-fluorouracil for colorectal cancer liver metastasis

AIM To evaluate the efficiency and safety of hepatic artery infusion chemotherapy(HAIC) using raltitrexed or 5-fluorouracil for colorectal cancer(CRC) liver metastasis(CRCLM).METHODS A retrospective analysis of patients with unresectable CRCLM who failed systemic chemotherapy and were subsequently treated with HAIC at our institute from May 2013 to April 2015 was performed. A total of 24 patients were treated with 5-fluorouracil, and 18 patients were treated with raltitrexed. RESULTS The median survival time(MST) from diagnosis of CRC was 40.8 mo in the oxaliplatin plus raltitrexed(TOMOX) arm and 33.5 mo in the oxaliplatin plus 5-fluorouracil(FOLFOX) arm(P = 0.802). MST from first HAIC was 20.6 mo in the TOMOX arm and 15.4 mo in the FOLFOX arm(P = 0.734). Median progression-free survival(PFS) from first HAIC was 4.9 mo and 6.6 mo, respectively, in the TOMOX arm and FOLFOX arm(P= 0.215). Leukopenia(P = 0.026) was more common in the FOLFOX arm, and hepatic disorder(P = 0.039) was more common in the TOMOX arm. There were no treatment-related deaths in the TOMOX arm and one treatment-related death in the FOLFOX arm. Analysis of prognostic factors indicated that response to HAIC was a significant factor related to survival.CONCLUSION No significant difference in survival was observed between the TOMOX and FOLFOX arms. HAIC treatment with either TOMOX or FOLFOX was demonstrated as an efficient and safe alternative choice.

Prognostic factors for transarterial chemoembolization combined with sustained oxaliplatin-based hepatic arterial infusion chemotherapy of colorectal cancer liver metastasis

Objective: To investigate the prognostic factors in chemorefractory colorectal cancer liver metastasis(CRCLM)patients treated by transarterial chemoembolization(TACE) and sustained hepatic arterial infusion chemotherapy(HAIC).Methods: Between 2006 and 2015, 162 patients who underwent 763 TACE and HAIC in total were enrolled in this retrospective study, including 110 males and 52 females, with a median age of 60(range, 26–83) years.Prognostic factors were assessed with Log-rank test, Cox univariate and multivariate analyses.Results: The median survival time(MST) and median progression-free survival(PFS) of the 162 patients from first TACE/HAIC were 15.6 months and 5.5 months respectively. Normal serum carbohydrate antigen 19-9(CA19-9, <37 U/m L)(P<0.001) and carbohydrate antigen 72-4(CA72-4, <6.7 U/m L)(P=0.026), combination with other local treatment(liver radiotherapy or liver radiofrequency ablation)(P=0.034) and response to TACE/HAIC(P<0.001) were significant factors related to survival after TACE/HAIC in univariate analysis. A multivariate analysis revealed that normal serum CA19-9(P<0.001), response to TACE/HAIC(P<0.001) and combination with other local treatment(P=0.001) were independent factors among them.Conclusions: Our findings indicate that serum CA19-9 <37 U/m L and response to TACE/HAIC are significant prognostic indicators for this combined treatment, and treated with other local treatment could reach a considerable survival benefit for CRCLM. This could be useful for making decisions regarding the treatment of CRCLM.

Chemoembolization alone vs combined chemoembolization and hepatic arterial infusion chemotherapy in inoperable hepatocellular carcinoma patients

AIM: To compare the efficacy and safety of chemoem-bolization alone or chemoembolization combined with hepatic arterial infusion chemotherapy(HAIC),including oxaliplatin(OXA),5-fluorouracil(5-FU) and folinic acid(CF),in inoperable hepatocellular carcinoma(HCC) without distant metastasis. METHODS: Eighty-four inoperable HCC patients were enrolled. Thirty-ninepatient sunderwent chemoembolization alone,and the other 45 patients underwent chemoembolization + HAIC(OXA/5-FU/CF) treatment non-randomly. The progression free survival(PFS),objective response rate(ORR),disease control rate(DCR) and adverse reactions were compared between the two groups.RESULTS: A significant difference in the ORR was observed between the chemoembolization alone and chemoembolization + HAIC groups. There was no statistically significant difference in DCR between the two groups. The median PFS(m PFS) showed a significant difference between the two groups. For patients with BCLC stage A/B disease,with or without vessel invasion,the chemoembolization + HAIC group showed better m PFS when compared to chemoembolization alone,but no significant difference was found in patients with BCLC stage C disease. The parameter of pain(grade Ⅲ-Ⅳ) in the chemoembolization + HAIC group was increased statistically. CONCLUSION: Chemoembolization combined with HAIC with OXA/5-FU/CF may be safe and more effective than chemoembolization alone for inoperable HCC patients without distant metastasis.