Objective:To explore the effects of combining application of diagnosis and treatment technologies of Event Related Potentials(ERP)and Psychic Rehabilitation Intervention(PRI)on rehabilitation of schizophrenia.Methods:...Objective:To explore the effects of combining application of diagnosis and treatment technologies of Event Related Potentials(ERP)and Psychic Rehabilitation Intervention(PRI)on rehabilitation of schizophrenia.Methods:PRI and ERP were used in schizophrenia rehabilitation in this research.232 patients were divided into study group(SG)and control group(CG),and the rehabilitation effects were compared.Results:(1)After the implementation of the PRI,more score of the Brief Psychiatric Rating Scale(BPRS)was reduced on SG than the score on CG;more decreased scores of insight and on Social Disability Screening Schedule(SDSS),and more increased scores of treatment compliance questionnaire scores were observed on SG,comparing with CG(P<0.05 or 0.01).(2)After the implementation of the PRI,more decreased factor scores of Symptom Checklist 90 were observed on SG patients family members(P<0.05 or 0.01).(3)PRI significantly improved the patients’social functions,family members’relationship and prevented the recurrence of schizophrenia.(4)Improved P2,P3 amplitudes were also detected on SG compared with CG(P<0.05).Conclusions:(1)PRI interventions may improve schizophrenia patients’social function.(2)ERP may be used to evaluate the schizophrenia patients’rehabilitation,and is worth being popularized.展开更多
Backgorund Nicotine may improve schizophrenia patient＇s cognitive deficit symptoms.This study was to explore the chronic effects of smoking on prepulse inhibition of the startle reflex （PPI） and P50 in the patients...Backgorund Nicotine may improve schizophrenia patient＇s cognitive deficit symptoms.This study was to explore the chronic effects of smoking on prepulse inhibition of the startle reflex （PPI） and P50 in the patients with first-episode schizophrenia （FES）.Methods The event-related potentials （ERP） recording and analysis instrument made by Brain Products,Germany,was used to detect PPI and P50 in 49 male FES patients （FES group,n=21 for smokers and n=28 for non-smokers） and 43 normal male controls （control group,n=19 for smokers and n=24 for non-smokers）.Results Compared with normal controls,the FES group had prolonged PPI latency when elicited by single stronger stimulus （P ＜0.05）; the FES group had prolonged PPI latency and increased PPI amplitude （P ＜0.05,0.01） when elicited by weak and strong stimuli.The FES group had lower PPI inhibition rate than normal controls （P ＜0.05）.Compared with normal controls,the FES group had increased P50-S2 amplitude and increased amplitude ratio S2/S1 （both P ＜0.05）.In the control group,the smokers had a tendency of increase in P50-S2 amplitude （P ＞0.05） and shorter P50-S2 latency （P ＜0.05） than the non-smokers.The smokers had higher PPI amplitude than the non-smokers （P ＜0.05）.In the FES group,the smokers had higher P50-S1 amplitude,shorter P50-S2 latency,and higher amplitude ratio S2/S1 than the non-smokers （P ＜0.05,0.01）.The smokers had higher PPI amplitude than the non-smokers （P ＜0.05）.Conclusions There is obvious PPI and P50 deficits in schizophrenic patients.However,these deficits are relatively preserved in the smokers compared with the non-smokers,which suggests that long-term smoking might partially improve the sensory gating in schizophrenic patients.Whether this conclusion can be deduced to female patients requires further follow-ups.展开更多
Anumber of therapies have been developed in the past decades.About two thirds of patients can be seizure free with antiepileptic drugs.1 Other patients are drug resistant,some of whom are good candidates for epileptic...Anumber of therapies have been developed in the past decades.About two thirds of patients can be seizure free with antiepileptic drugs.1 Other patients are drug resistant,some of whom are good candidates for epileptic focus resection and become seizure free after surgery.2 The treatment for drug-resistant patients who are not eligible for resection is still challenging.Traditionally,these patients can receive palliative surgery such as callosotomy and multiple subpial transection,3,4 but the long-term outcomes of these procedures are not satisfactory.5-7 In the past decades,neuromodulation techniques have been applied in the treatment of epilepsy.Much evidence has been accumulated about the therapeutic effects of vagus nerve stimulation for epilepsy.In contrast to peripheral nerve stimulation,brain stimulation techniques have also been developed for patients with epilepsy recently.展开更多
双源能量平衡模型(Two Source Energy Balance,TSEB)和双温度差模型(Dual Temperature Difference,DTD)目前已应用于不同的下垫面类型和环境条件下地表蒸散发估算研究,但是由于模型构建理论机理的差异,模型表现会随着下垫面类型和环境...双源能量平衡模型(Two Source Energy Balance,TSEB)和双温度差模型(Dual Temperature Difference,DTD)目前已应用于不同的下垫面类型和环境条件下地表蒸散发估算研究,但是由于模型构建理论机理的差异,模型表现会随着下垫面类型和环境条件的变化而有所不同。因此,本研究选取了黑河流域高寒草地、半干旱区灌溉农田以及干旱区河岸林3种下垫面类型地面观测数据,系统分析了DTD模型和TSEB模型的适用性以及主要误差来源。结果表明:①在瞬时尺度上,DTD模型在高寒草地上估算潜热通量的误差较小,其RMSE为62.00 W/m2,而TSEB模型的RMSE为75.49 W/m2,2个模型的精度会随着植被覆盖度的增加而出现差异;在半干旱区灌溉农田区域,2种模型表现较为一致,但是在干旱区河岸林,2种模型都低估了潜热通量,且模型误差较大;②在日尺度上,DTD模型和TSEB模型的表现与瞬时尺度表现较为一致,同时2种模型拆分的植被蒸腾比与基于uWUE模型(Water Use Efficiency,u WUE)拆分的结果吻合较好,但DTD模型的表现要优于TSEB模型;③相比较DTD模型而言,TSEB模型对地表温度输入误差更为敏感。本研究通过对比DTD模型和TSEB模型在不同下垫面和环境条件的表现,为今后模型优化提供了理论依据。展开更多
文摘Objective:To explore the effects of combining application of diagnosis and treatment technologies of Event Related Potentials(ERP)and Psychic Rehabilitation Intervention(PRI)on rehabilitation of schizophrenia.Methods:PRI and ERP were used in schizophrenia rehabilitation in this research.232 patients were divided into study group(SG)and control group(CG),and the rehabilitation effects were compared.Results:(1)After the implementation of the PRI,more score of the Brief Psychiatric Rating Scale(BPRS)was reduced on SG than the score on CG;more decreased scores of insight and on Social Disability Screening Schedule(SDSS),and more increased scores of treatment compliance questionnaire scores were observed on SG,comparing with CG(P<0.05 or 0.01).(2)After the implementation of the PRI,more decreased factor scores of Symptom Checklist 90 were observed on SG patients family members(P<0.05 or 0.01).(3)PRI significantly improved the patients’social functions,family members’relationship and prevented the recurrence of schizophrenia.(4)Improved P2,P3 amplitudes were also detected on SG compared with CG(P<0.05).Conclusions:(1)PRI interventions may improve schizophrenia patients’social function.(2)ERP may be used to evaluate the schizophrenia patients’rehabilitation,and is worth being popularized.
基金This study was supported by the grants from the National Natural Science Foundation of China （No. 81271480, No. 81372122）, the emerging advanced technology projects from Shanghai Hospital Development Center （SHDC 12013116）, projects of Shanghai Shen Kang municipality hospital appropriate technology development and application （SHDC 12012234） and projects of promotion of advanced appropriate technology in health service in Shanghai （2013 SY069）.
文摘Backgorund Nicotine may improve schizophrenia patient＇s cognitive deficit symptoms.This study was to explore the chronic effects of smoking on prepulse inhibition of the startle reflex （PPI） and P50 in the patients with first-episode schizophrenia （FES）.Methods The event-related potentials （ERP） recording and analysis instrument made by Brain Products,Germany,was used to detect PPI and P50 in 49 male FES patients （FES group,n=21 for smokers and n=28 for non-smokers） and 43 normal male controls （control group,n=19 for smokers and n=24 for non-smokers）.Results Compared with normal controls,the FES group had prolonged PPI latency when elicited by single stronger stimulus （P ＜0.05）; the FES group had prolonged PPI latency and increased PPI amplitude （P ＜0.05,0.01） when elicited by weak and strong stimuli.The FES group had lower PPI inhibition rate than normal controls （P ＜0.05）.Compared with normal controls,the FES group had increased P50-S2 amplitude and increased amplitude ratio S2/S1 （both P ＜0.05）.In the control group,the smokers had a tendency of increase in P50-S2 amplitude （P ＞0.05） and shorter P50-S2 latency （P ＜0.05） than the non-smokers.The smokers had higher PPI amplitude than the non-smokers （P ＜0.05）.In the FES group,the smokers had higher P50-S1 amplitude,shorter P50-S2 latency,and higher amplitude ratio S2/S1 than the non-smokers （P ＜0.05,0.01）.The smokers had higher PPI amplitude than the non-smokers （P ＜0.05）.Conclusions There is obvious PPI and P50 deficits in schizophrenic patients.However,these deficits are relatively preserved in the smokers compared with the non-smokers,which suggests that long-term smoking might partially improve the sensory gating in schizophrenic patients.Whether this conclusion can be deduced to female patients requires further follow-ups.
基金This study was supported by the grants from the National Natural Science Foundation of China （No. 81271480 and No. 81372122）, the Emerging Advanced Technology Projects from Shanghai Hospital Development Center （SHDC 12013116）, and Projects of Promotion of Advanced Appropriate Technology in Health Service in Shanghai （No. 2013SY069）.
文摘Anumber of therapies have been developed in the past decades.About two thirds of patients can be seizure free with antiepileptic drugs.1 Other patients are drug resistant,some of whom are good candidates for epileptic focus resection and become seizure free after surgery.2 The treatment for drug-resistant patients who are not eligible for resection is still challenging.Traditionally,these patients can receive palliative surgery such as callosotomy and multiple subpial transection,3,4 but the long-term outcomes of these procedures are not satisfactory.5-7 In the past decades,neuromodulation techniques have been applied in the treatment of epilepsy.Much evidence has been accumulated about the therapeutic effects of vagus nerve stimulation for epilepsy.In contrast to peripheral nerve stimulation,brain stimulation techniques have also been developed for patients with epilepsy recently.
文摘双源能量平衡模型(Two Source Energy Balance,TSEB)和双温度差模型(Dual Temperature Difference,DTD)目前已应用于不同的下垫面类型和环境条件下地表蒸散发估算研究,但是由于模型构建理论机理的差异,模型表现会随着下垫面类型和环境条件的变化而有所不同。因此,本研究选取了黑河流域高寒草地、半干旱区灌溉农田以及干旱区河岸林3种下垫面类型地面观测数据,系统分析了DTD模型和TSEB模型的适用性以及主要误差来源。结果表明:①在瞬时尺度上,DTD模型在高寒草地上估算潜热通量的误差较小,其RMSE为62.00 W/m2,而TSEB模型的RMSE为75.49 W/m2,2个模型的精度会随着植被覆盖度的增加而出现差异;在半干旱区灌溉农田区域,2种模型表现较为一致,但是在干旱区河岸林,2种模型都低估了潜热通量,且模型误差较大;②在日尺度上,DTD模型和TSEB模型的表现与瞬时尺度表现较为一致,同时2种模型拆分的植被蒸腾比与基于uWUE模型(Water Use Efficiency,u WUE)拆分的结果吻合较好,但DTD模型的表现要优于TSEB模型;③相比较DTD模型而言,TSEB模型对地表温度输入误差更为敏感。本研究通过对比DTD模型和TSEB模型在不同下垫面和环境条件的表现,为今后模型优化提供了理论依据。
