Sixteen diterpenoid alkaloids(DAs),including six aconitine-type alkaloids(5 and 9−13),seven 7,17-seco-aconitine-type alkaloids(1−4,6−8),two napelline-type alkaloids(14 and 15)as well as one veatchine-type alkaloid(16)...Sixteen diterpenoid alkaloids(DAs),including six aconitine-type alkaloids(5 and 9−13),seven 7,17-seco-aconitine-type alkaloids(1−4,6−8),two napelline-type alkaloids(14 and 15)as well as one veatchine-type alkaloid(16),were isolated from the aerial parts of Aconitum flavum Hand.-Mazz.In which,flavumolines A−D(1−4)were four new ones,and flavu-moline E(5)was reported as natural compound for the first time.Their chemical structures were elucidated by the analysis of extensive spectroscopic data.The inhibitory activities of these isolates on Cav3.1 low voltage-gated Ca^(2+)channel,NO production in LPS-activated RAW264.7cells,five human tumor cell lines,as well as acetylcholinesterase(AChE)were tested.展开更多
Open Access This article is licensed under a Creative Commons Attri-bution 4.0 International License,which permits use,sharing,adapta-tion,distribution and reproduction in any medium or format,as long as you give appr...Open Access This article is licensed under a Creative Commons Attri-bution 4.0 International License,which permits use,sharing,adapta-tion,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons license,and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license,unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use,you will need to obtain permission directly from the copyright holder.To view a copy of this license,visit http://creat iveco mmons.org/licen ses/by/4.0/.展开更多
Saldigones A-C(1,3,4),three new isoprenylated flavonoids with diverse flavanone,pterocarpan,and isoflavanone architec-tures,were characterized from the roots of Salvia digitaloides,together with a known isoprenylated ...Saldigones A-C(1,3,4),three new isoprenylated flavonoids with diverse flavanone,pterocarpan,and isoflavanone architec-tures,were characterized from the roots of Salvia digitaloides,together with a known isoprenylated flavanone(2).Notably,it’s the first report of isoprenylated flavonoids from Salvia species.The structures of these isolates were elucidated by extensive spectroscopic analysis.All of the compounds were evaluated for their activities on Cav3.1 low voltage-gated Ca^(2+)channel(LVGCC),of which 2 strongly and dose-dependently inhibited Cav3.1 peak current.展开更多
基金the Second Tibetan Plateau Scientific Expedition and Research(STEP)program(2019QZKK0502)State Key Laboratory of Phytochemistry and Plant Resources in West China(P2017-KF02 and P2019-ZZ05)the Natural Sciences Foundation of Yunnan Province(2019FA003).
文摘Sixteen diterpenoid alkaloids(DAs),including six aconitine-type alkaloids(5 and 9−13),seven 7,17-seco-aconitine-type alkaloids(1−4,6−8),two napelline-type alkaloids(14 and 15)as well as one veatchine-type alkaloid(16),were isolated from the aerial parts of Aconitum flavum Hand.-Mazz.In which,flavumolines A−D(1−4)were four new ones,and flavu-moline E(5)was reported as natural compound for the first time.Their chemical structures were elucidated by the analysis of extensive spectroscopic data.The inhibitory activities of these isolates on Cav3.1 low voltage-gated Ca^(2+)channel,NO production in LPS-activated RAW264.7cells,five human tumor cell lines,as well as acetylcholinesterase(AChE)were tested.
文摘Open Access This article is licensed under a Creative Commons Attri-bution 4.0 International License,which permits use,sharing,adapta-tion,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons license,and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license,unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use,you will need to obtain permission directly from the copyright holder.To view a copy of this license,visit http://creat iveco mmons.org/licen ses/by/4.0/.
基金the Foundation of Supported by National Natural Science Foundation of China(32070392 and 32070393)the Second Tibetan Plateau Scientific Expedition and Research(STEP)program(2019QZKK0502-0303).
文摘Saldigones A-C(1,3,4),three new isoprenylated flavonoids with diverse flavanone,pterocarpan,and isoflavanone architec-tures,were characterized from the roots of Salvia digitaloides,together with a known isoprenylated flavanone(2).Notably,it’s the first report of isoprenylated flavonoids from Salvia species.The structures of these isolates were elucidated by extensive spectroscopic analysis.All of the compounds were evaluated for their activities on Cav3.1 low voltage-gated Ca^(2+)channel(LVGCC),of which 2 strongly and dose-dependently inhibited Cav3.1 peak current.
