Main observation and conclusion Stereoselective isomerization of a-alkyl styrenes is accomplished using a new iron catalyst supported by phosphine-pyridine-oxazoline(PPO)ligand.The protocol provides an atom-efficient ...Main observation and conclusion Stereoselective isomerization of a-alkyl styrenes is accomplished using a new iron catalyst supported by phosphine-pyridine-oxazoline(PPO)ligand.The protocol provides an atom-efficient and operationally simple approach to trisubstituted alkenes in high yields with excellent regio-and stereoselectivities under mild conditions.The results of deuterium-labelling and radical trap experiments are consistent with an iron-hydride pathway involving reversible alkene insertion andβ-H elimination.展开更多
基金the National Natural Science Foundation of China(Nos.21825109,21821002,21732006)the National Basic Research Program of China(No.2016YFA0202900)+2 种基金the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB20000000)the Chinese Academy of Sciences Key Research Program of Frontier Sciences(No.QYZDB-SSW-SLH016)the K.C.Wong Education Foundation,and the Science and Technology Commission of Shanghai Municipality(No.17JC1401200)is gratefully acknowledged.
文摘Main observation and conclusion Stereoselective isomerization of a-alkyl styrenes is accomplished using a new iron catalyst supported by phosphine-pyridine-oxazoline(PPO)ligand.The protocol provides an atom-efficient and operationally simple approach to trisubstituted alkenes in high yields with excellent regio-and stereoselectivities under mild conditions.The results of deuterium-labelling and radical trap experiments are consistent with an iron-hydride pathway involving reversible alkene insertion andβ-H elimination.
