A novel continuous flow method for the methoxylation of chloronitrobenzenes was developed. The reaction went smoothly and high yields were achieved under the optimized conditions. Furthermore, up to 76% yield of azoxy...A novel continuous flow method for the methoxylation of chloronitrobenzenes was developed. The reaction went smoothly and high yields were achieved under the optimized conditions. Furthermore, up to 76% yield of azoxybenzenes were obtained from the corresponding nitrobenzenes in the presence of NaOH in continuous flow. Compared to batch conditions, the reaction time was significantly shortened, and the chemical waste was reduced obviously.展开更多
基金This Science work was supported by the National Natural Foundation of China （Nos. 21502090, 21522604）, Natural Science Foundation of Jiangsu Province （Nos. BK20150942, BK20150031） and the National Key Basic Research Program of China （No. 2012CB725204）. We also thank the financial support from Top-notch Academic Programs Project of Jiangsu Higher Education Institutions （TAPP）.
文摘A novel continuous flow method for the methoxylation of chloronitrobenzenes was developed. The reaction went smoothly and high yields were achieved under the optimized conditions. Furthermore, up to 76% yield of azoxybenzenes were obtained from the corresponding nitrobenzenes in the presence of NaOH in continuous flow. Compared to batch conditions, the reaction time was significantly shortened, and the chemical waste was reduced obviously.
