Background: We report on a patient with Graves’disease with radiation retinop athy caused by low-dose irradiation and antithyroid drug-induced antineutrophi l cytoplasmic antibody (ANCA)-positive vasculitis. Case: A ...Background: We report on a patient with Graves’disease with radiation retinop athy caused by low-dose irradiation and antithyroid drug-induced antineutrophi l cytoplasmic antibody (ANCA)-positive vasculitis. Case: A 38-year-old woman with Graves’disease presented with bilateral blurred vision, microaneurysms, te langiectasia, and macular edema. The patientwas examined by ophthalmoscopy and f luorescein angiography, and radiation retinopathywas diagnosed. Observations: Th e patient had been treated with low-dose irradiation for her Graves’ophthalmop athy a few years earlier. She also had ANCA-positive vasculitis induced by the antithyroid drug (propylthiouracil, PTU) that had been prescribed for her at tha t time. Because of multiple avascular areas on both retinas, she was treated by intensive retinal photocoagulation to control progressive retinopathy. Conclusio ns: The radiation doses used to treat Graves’disease ophthalmopathy are low. Ne vertheless, there is still a risk of radiation retinopathy developing in patient s with PTU-induced ANCA-positive vasculitis.展开更多
文摘Background: We report on a patient with Graves’disease with radiation retinop athy caused by low-dose irradiation and antithyroid drug-induced antineutrophi l cytoplasmic antibody (ANCA)-positive vasculitis. Case: A 38-year-old woman with Graves’disease presented with bilateral blurred vision, microaneurysms, te langiectasia, and macular edema. The patientwas examined by ophthalmoscopy and f luorescein angiography, and radiation retinopathywas diagnosed. Observations: Th e patient had been treated with low-dose irradiation for her Graves’ophthalmop athy a few years earlier. She also had ANCA-positive vasculitis induced by the antithyroid drug (propylthiouracil, PTU) that had been prescribed for her at tha t time. Because of multiple avascular areas on both retinas, she was treated by intensive retinal photocoagulation to control progressive retinopathy. Conclusio ns: The radiation doses used to treat Graves’disease ophthalmopathy are low. Ne vertheless, there is still a risk of radiation retinopathy developing in patient s with PTU-induced ANCA-positive vasculitis.
