When I sat down to write the first sentences of this doc-ument,everything was blurred,hazy,and shrouded,as though I were in a dense,cloudy fog that I could not quite describe.About 10 years ago,I was a young infectiou...When I sat down to write the first sentences of this doc-ument,everything was blurred,hazy,and shrouded,as though I were in a dense,cloudy fog that I could not quite describe.About 10 years ago,I was a young infectious disease(ID)physician working in a ward at the largest university hospital in Tunis,Tunisia,designed to accom-modate about 60 patients.Despite working in a country where we sometimes lacked logistical resources and tech-nical facilities and platforms,we never lacked willpower and thoroughness.We sometimes ran through the long corridors of the old buildings to perform exams and trans-fer patients,even using our own cars to travel from one department to another.Everything was justified by the goals of caring for our patients and saving lives.展开更多
Background:The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),began in late 2019.More recently,there have been sporadic case reports on devel-opment of...Background:The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),began in late 2019.More recently,there have been sporadic case reports on devel-opment of Miller-Fisher Syndrome,a rare variant of Guillain-BarréSyndrome in COVID-19 patients.Case report:We reported herein the case of a French young women presenting with ophtalmoplegia,cerebellar ataxia,and universal areflexia following a bariatric surgery(sleeve gastrectomy).A concomitant COVID-19 diagnosis was retained based on microbiological testing.The patient was successfully treated after high-dose intravenous thiamine,but areflexia persisted.Underlying COVID-19 related Miller-Fisher Syndrome was established on physical examination and confirmed by pathologic neurophysiological findings and elevated level of phosphorylated neurofilament heavy chain protein in cerebrospinal fluid analysis.Conclusions:Guillain-BarréSyndrome and its variants after SARS-CoV-2 infection are extremely rare.The mea-surement of phosphorylated neurofilament heavy chain protein should be considered as an easy tool to detect an early affection of the peripheral nervous system.展开更多
In this current case series,all Coronavirus disease 2019 patients had predominant ophthalmological presentation.Only one patient sough care for concomitant respiratory symptoms.We reported herein 2 cases with cranial ...In this current case series,all Coronavirus disease 2019 patients had predominant ophthalmological presentation.Only one patient sough care for concomitant respiratory symptoms.We reported herein 2 cases with cranial oculomotor nerve palsy,one patient with confirmed diagnosis of branch retinal vein occlusion,and the last one patient presenting for acute kareto-conjunctivitis with several recurrences,which was unsuccessfully treated with steroids and requiring cliclosporin.These case series highlights the importance of collecting a careful history of ocular presentation,including exposures to possible infected patients with SARS-CoV-2.This this will lead to an early diagnosis and treatment and to make appropriate infection control measures.展开更多
Non-tuberculous mycobacteria are a significant cause of pulmonary infections worldwide and can be clinically challenging.Mycobacterium xenopi(M.xenopi)has a low pathogenicity and usually requires immunosuppression or ...Non-tuberculous mycobacteria are a significant cause of pulmonary infections worldwide and can be clinically challenging.Mycobacterium xenopi(M.xenopi)has a low pathogenicity and usually requires immunosuppression or lung diseases.We describe herein a scarce case of pulmonary cavitary disease attributed to M.xenopi in a 57-year-old Caucasian patient with underlying structural lung disease successfully treated with rifampicin,ethambutol,clarithromycin,and amikacin.展开更多
文摘When I sat down to write the first sentences of this doc-ument,everything was blurred,hazy,and shrouded,as though I were in a dense,cloudy fog that I could not quite describe.About 10 years ago,I was a young infectious disease(ID)physician working in a ward at the largest university hospital in Tunis,Tunisia,designed to accom-modate about 60 patients.Despite working in a country where we sometimes lacked logistical resources and tech-nical facilities and platforms,we never lacked willpower and thoroughness.We sometimes ran through the long corridors of the old buildings to perform exams and trans-fer patients,even using our own cars to travel from one department to another.Everything was justified by the goals of caring for our patients and saving lives.
文摘Background:The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),began in late 2019.More recently,there have been sporadic case reports on devel-opment of Miller-Fisher Syndrome,a rare variant of Guillain-BarréSyndrome in COVID-19 patients.Case report:We reported herein the case of a French young women presenting with ophtalmoplegia,cerebellar ataxia,and universal areflexia following a bariatric surgery(sleeve gastrectomy).A concomitant COVID-19 diagnosis was retained based on microbiological testing.The patient was successfully treated after high-dose intravenous thiamine,but areflexia persisted.Underlying COVID-19 related Miller-Fisher Syndrome was established on physical examination and confirmed by pathologic neurophysiological findings and elevated level of phosphorylated neurofilament heavy chain protein in cerebrospinal fluid analysis.Conclusions:Guillain-BarréSyndrome and its variants after SARS-CoV-2 infection are extremely rare.The mea-surement of phosphorylated neurofilament heavy chain protein should be considered as an easy tool to detect an early affection of the peripheral nervous system.
文摘In this current case series,all Coronavirus disease 2019 patients had predominant ophthalmological presentation.Only one patient sough care for concomitant respiratory symptoms.We reported herein 2 cases with cranial oculomotor nerve palsy,one patient with confirmed diagnosis of branch retinal vein occlusion,and the last one patient presenting for acute kareto-conjunctivitis with several recurrences,which was unsuccessfully treated with steroids and requiring cliclosporin.These case series highlights the importance of collecting a careful history of ocular presentation,including exposures to possible infected patients with SARS-CoV-2.This this will lead to an early diagnosis and treatment and to make appropriate infection control measures.
文摘Non-tuberculous mycobacteria are a significant cause of pulmonary infections worldwide and can be clinically challenging.Mycobacterium xenopi(M.xenopi)has a low pathogenicity and usually requires immunosuppression or lung diseases.We describe herein a scarce case of pulmonary cavitary disease attributed to M.xenopi in a 57-year-old Caucasian patient with underlying structural lung disease successfully treated with rifampicin,ethambutol,clarithromycin,and amikacin.
