Aim:To report on a unique case of hypogonadism associated with excessive carotene intake in a young male athlete. Case report:A 20-year-old patient presented with a gradual decline in muscular and physical activity,se...Aim:To report on a unique case of hypogonadism associated with excessive carotene intake in a young male athlete. Case report:A 20-year-old patient presented with a gradual decline in muscular and physical activity,sexual interest and erectile ability associated with a high in carotene and low in animal fat diet of his own design a year prior to the clinical manifestations.Clinically,he presented with very overt signs of carotene excess:his palms and soles were yellow.Moreover,2 weeks after normalization of his diet,carotene B levels were at the upper end of the normal range.Methods:Repeated stimulation tests of hypothalamic,pituitary and testicular function were performed before and at 3,6 and 12 months after the introduction of a balanced diet.Results:Very low basal and stimulated values for gonadotropins and gonadal steroids were found at the initial evaluation with a progressive recovery shown after months of a balanced diet and carotene B restoration.Complete androgen secretion and sexual response recovery were observed only after 9-12 months from diagnosis.Conclusion:This is the first report associating excessive carotene intake with a hypothalamic form of hypogonadism in a young man.(Asian J Androl 2006 Jul;8:488-492)展开更多
文摘Aim:To report on a unique case of hypogonadism associated with excessive carotene intake in a young male athlete. Case report:A 20-year-old patient presented with a gradual decline in muscular and physical activity,sexual interest and erectile ability associated with a high in carotene and low in animal fat diet of his own design a year prior to the clinical manifestations.Clinically,he presented with very overt signs of carotene excess:his palms and soles were yellow.Moreover,2 weeks after normalization of his diet,carotene B levels were at the upper end of the normal range.Methods:Repeated stimulation tests of hypothalamic,pituitary and testicular function were performed before and at 3,6 and 12 months after the introduction of a balanced diet.Results:Very low basal and stimulated values for gonadotropins and gonadal steroids were found at the initial evaluation with a progressive recovery shown after months of a balanced diet and carotene B restoration.Complete androgen secretion and sexual response recovery were observed only after 9-12 months from diagnosis.Conclusion:This is the first report associating excessive carotene intake with a hypothalamic form of hypogonadism in a young man.(Asian J Androl 2006 Jul;8:488-492)
