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Comprehensive semen examination in patients with pancreatic-sufficient and pancreatic-insufficient cystic fibrosis
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作者 anna O Sedova Maria I Shtaut +7 位作者 Elizaveta E Bragina Tatyana M Sorokina Galina V Shmarina Marina V andreeva Lyubov E Kurilo stanislav a krasovskiy aleksander V Polyakov Vyacheslav B Chernykh 《Asian Journal of Andrology》 SCIE CAS CSCD 2023年第5期591-597,共7页
We examined a cohort of 93 cystic fibrosis(CF)male patients who were pancreatic-sufficient(PS-CF;n=40)or pancreatic-insufficient(PI-CF;n=53).Complex semen examination was performed,including standard semen analysis,qu... We examined a cohort of 93 cystic fibrosis(CF)male patients who were pancreatic-sufficient(PS-CF;n=40)or pancreatic-insufficient(PI-CF;n=53).Complex semen examination was performed,including standard semen analysis,quantitative karyological analysis(QKA)of immature germ cells(IGCs),transmission electronic microscopy(TEM),biochemical analysis,and sperm DNA fragmentation by terminal deoxynucleotidyl transferase-mediated dUTP nickend labeling(TUNEL)assay.Azoospermia was diagnosed in 83(89.2%)patients.The other 10(10.8%)patients were found to be nonazoospermic and showed various spermatological diagnoses(asthenozoospermia,n=2;asthenoteratozoospermia,n=3;oligoasthenozoospermia,n=1;oligoasthenoteratozoospermia,n=3;and normozoospermia,n=1)with no specific morphological abnormalities.Oligospermia was detected in 89.2%azoospermic and 30.0%nonazoospermic patients.Low seminal pH(<7.0)was found in 74(89.2%)of 83 azoospermic patients.Moderate leukocytospermia(2.0×10^(6)-2.2×10^(6)ml^(-1))was revealed in 2.4%azoospermic and 40.0%nonazoospermic semen samples.The signs of partial meiotic arrest at prophase I were found in 4 of 6 nonazoospermic patients examined by QKA of IGCs.The content of fructose and citrate was low in oligospermic and normal in nonoligospermic semen samples.An increased percentage(>30%)of spermatozoa with noncondensed(“immature”)chromatin was revealed in 2 of 6 nonazoospermic semen samples analyzed by TEM. 展开更多
关键词 congenital bilateral agenesia/aplasia of vas deferens cystic fibrosis cystic fibrosis transmembrane conductance regulator gene SEMEN SPERMATOZOA
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