It has been unclear why SARS-CoV-2 with a D614G mutation in the spike protein became dominant early in the COVID-19 pandemic.A recent study by Hou et al.published in Science shows that D614G increases SARS-CoV-2 sprea...It has been unclear why SARS-CoV-2 with a D614G mutation in the spike protein became dominant early in the COVID-19 pandemic.A recent study by Hou et al.published in Science shows that D614G increases SARS-CoV-2 spread in cultured human nasal epithelium and enhances transmission in a hamster model.展开更多
The spike(S)protein of the SARS-CoV-2 Omicron variant is highly mutated but the impact of these mutations on viral entry into cells and its inhibition by antibodies has been unclear.A recent study published in Science...The spike(S)protein of the SARS-CoV-2 Omicron variant is highly mutated but the impact of these mutations on viral entry into cells and its inhibition by antibodies has been unclear.A recent study published in Science by Mannar et al.now shows that these mutations are compatible with robust ACE2 binding and allow for efficient evasion of neutralizing antibodies.The emergence of SARS-CoV-2 variants has become a hallmark of the COVID-19 pandemic.Variants of concern(VOC)harbor mutations in the viral S protein that can increase transmissibility,potentially by promoting S protein binding to the cellular receptor ACE2.展开更多
基金The Pohlmann lab is supported by BMBF(RAPID Consortium,01KI1723D,and 01KI2006D,RENACO,01KI20328A,01KI20396,COVIM consortium).
文摘It has been unclear why SARS-CoV-2 with a D614G mutation in the spike protein became dominant early in the COVID-19 pandemic.A recent study by Hou et al.published in Science shows that D614G increases SARS-CoV-2 spread in cultured human nasal epithelium and enhances transmission in a hamster model.
基金The Pöhlmann lab was supported by funds from the Bundesministerium für Bildung und Forschung(BMBFprojects 01KI2006D,01KI20328A,01KX2021)+1 种基金Deutsche Forschungsgemeinschaft(DFG,PO 716/14-1,PO 716/11-1)and Niedersächsisches Ministerium für Wissenschaft und Kultur(COFONI Network)Z.L.was supported by the China Scholarship Council(CSC)(202006270031).
文摘The spike(S)protein of the SARS-CoV-2 Omicron variant is highly mutated but the impact of these mutations on viral entry into cells and its inhibition by antibodies has been unclear.A recent study published in Science by Mannar et al.now shows that these mutations are compatible with robust ACE2 binding and allow for efficient evasion of neutralizing antibodies.The emergence of SARS-CoV-2 variants has become a hallmark of the COVID-19 pandemic.Variants of concern(VOC)harbor mutations in the viral S protein that can increase transmissibility,potentially by promoting S protein binding to the cellular receptor ACE2.
